Hydroxyapatite in Bioprocessing

Hilbrig, Frank; Freitag, Ruth

doi:10.1002/9783527653096.ch9

Cited by 8 publications

(8 citation statements)

References 122 publications

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“…[28][29][30] Hydroxyapatite has high adsorption capacity because its positively-charged surface interacts with deprotonated carboxyl groups and other negatively-charged groups present in the antibiotic molecules. [31] Hydroxyapatite coatings loaded with antibiotics are used as bone implant coatings to prevent bacterial adhesion. A technique was used to coat titanium implants by a single-stage electrophoretically-driven deposition of hydroxyapatite nanoparticles loaded with antibiotics (Figure 4A).…”

Section: Antibiotic Deliverymentioning

confidence: 99%

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Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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Section: Antibiotic Deliverymentioning

confidence: 99%

“…[ 28–30 ] Hydroxyapatite has high adsorption capacity because its positively‐charged surface interacts with deprotonated carboxyl groups and other negatively‐charged groups present in the antibiotic molecules. [ 31 ]…”

Section: Antibiotic Deliverymentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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“…83 Excellent adsorption properties of hydroxyapatite are the result of its positively charged surface Ca 2+ ions engaging in an anion-exchange interaction with deprotonated carboxyl groups of proteins and the negatively charged PO 4 3− groups engaging in a cation-exchange interaction with protonated amino groups of proteins. 84 Moreover, hydroxyapatite possesses different net charges on the a and c planes of its hexagonal crystal lattice—positive and negative, respectively, 85 which renders it effective in the crystallographically selective binding of multiple molecular entities. Other variations of hydroxyapatite, such as carbonated apatite 86 and biphasic calcium phosphate, 87 possessed an even greater protein adsorption capacity, given an identical particle size and specific surface area, which was hypothesized to be due to their greater solubility, which increases the ionic strength in the medium and the surface exposition of the polar residues of proteins, thus increasing the binding efficacy.…”

Section: Advanced Drug Delivery Platforms In the Research Stagementioning

confidence: 99%

Nanostructured Platforms for the Sustained and Local Delivery of Antibiotics in the Treatment of Osteomyelitis

Uskoković

2015

Crit Rev Ther Drug Carrier Syst

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This article provides a critical view of the current state of the development of nanoparticulate and other solid-state carriers for the local delivery of antibiotics in the treatment of osteomyelitis. Mentioned are the downsides of traditional means for treating bone infection, which involve systemic administration of antibiotics and surgical debridement, along with the rather imperfect local delivery options currently available in the clinic. Envisaged are more sophisticated carriers for the local and sustained delivery of antimicrobials, including bioresorbable polymeric, collagenous, liquid crystalline, and bioglass- and nanotube-based carriers, as well as those composed of calcium phosphate, the mineral component of bone and teeth. A special emphasis is placed on composite multifunctional antibiotic carriers of a nanoparticulate nature and on their ability to induce osteogenesis of hard tissues demineralized due to disease. An ideal carrier of this type would prevent the long-term, repetitive, and systemic administration of antibiotics and either minimize or completely eliminate the need for surgical debridement of necrotic tissue. Potential problems faced by even hypothetically “perfect” antibiotic delivery vehicles are mentioned too, including (i) intracellular bacterial colonies involved in recurrent, chronic osteomyelitis; (ii) the need for mechanical and release properties to be adjusted to the area of surgical placement; (iii) different environments in which in vitro and in vivo testings are carried out; (iv) unpredictable synergies between drug delivery system components; and (v) experimental sensitivity issues entailing the increasing subtlety of the design of nanoplatforms for the controlled delivery of therapeutics.

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“…Hydroxyapatite (HAp, Ca 5 (PO 4 ) 3 OH) has been widely utilized as a biomaterial due to its superior bioactivity, biocompatibility, and nontoxicity . In addition, HAp has been extensively studied as an efficient drug carrier because of its capacity to adsorb various functional groups, such as carboxylic acids, amines, and phosphates among others. , Therefore, employing HAp as efficient nanovehicles for Dox delivery is considered highly appealing. Zheng et al used PLGA-HAp nanocomposite fibers as a nanocarrier for the sustained release of Dox .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Triggered Dissolution of Hydroxyapatite/Doxorubicin Nanocarriers

Geuli

Miller

Leader

et al. 2019

ACS Appl. Bio Mater.

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The controlled release of drugs by an external stimulus is of pivotal interest and importance as a means of increasing administration efficacy. Accordingly, many responsive systems have been developed based on primarily pH, temperature, and light changes. Here, a novel electrochemical triggered release of a doxorubicin (Dox)loaded hydroxyapatite (HAp) nanoparticle (NP) system is presented. Dox is loaded onto HAp NPs by producing a stable dispersion in DMSO. The Dox-HAp NPs are electrophoretically deposited on a stainless steel (S.S) surface. The adsorbed Dox-HAp NPs are released either by applying a moderate electrochemical potential pulse or upon scanning the potential. Two mechanisms were proposed. The first is that the positive potential induces the desorption of the Dox-HAp NPs. Alternatively, the positive potential could drive the oxidation of water and generation of protons, causing the dissolution of the Dox-HAp NPs. In situ characterization techniques, such as atomic force microscopy (AFM) and confocal microscopy, were used to gain insight on the release mechanism. All measurements allude to the electrochemically driven dissolution of the Dox-HAp NPs and release of the embedded drug. In vitro antitumor activity against both HT-29 and A2780 cancer cells revealed that the efficacy of the released Dox was not significantly affected by the electrochemical process. We believe that the electrochemically triggered release of NPs could be applied to many other responsive systems.

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Hydroxyapatite in Bioprocessing

Cited by 8 publications

References 122 publications

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Nanostructured Platforms for the Sustained and Local Delivery of Antibiotics in the Treatment of Osteomyelitis

Electrochemical Triggered Dissolution of Hydroxyapatite/Doxorubicin Nanocarriers

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