Hydroxyapatite formation with the interface of chitin and chitosan

Lin, Chen Yong; Chen, Yu Sheng; Wei, Huang; Hung, Tzung Chin; Wen, Ten Chin

doi:10.1016/j.jtice.2021.01.004

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…The EDS mapping results showed distinct signals for the elements Ca and P in CPP and apatite-like deposits. The Ca:P ratio of CPP is 0.51 and apatite-like deposits was about 2.31, which is similar to hydroxyapatite [53,54]. Surprisingly, from the inset SEM images of figure 8(a), many substances similar to the nucleation of hydroxyapatite crystals were also clearly observed on CS-rGO/0.3 but none on CPP.…”

Section: Biomineralizationmentioning

confidence: 82%

The construction of a self-assembled coating with chitosan-grafted reduced graphene oxide on porous calcium polyphosphate scaffolds for bone tissue engineering

Ding¹,

Xu²,

Hu³

et al. 2022

Biomed. Mater.

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Bone regeneration in large bone defects remains one of the major challenges in orthopedic surgery. Calcium polyphosphate (CPP) scaffolds possess excellent biocompatibility and exhibits good bone ingrowth. However, the present CPP scaffolds lack enough osteoinductive activity to facilitate bone regeneration at bone defects that exceed the critical size threshold. To endow CPP scaffolds with improved osteoinductive activity for better bone regeneration, in this study, a self-assembled coating with chitosan-grafted reduced graphene oxide (CS-rGO) sheets was successfully constructed onto the surface of CPP scaffolds through strong electrostatic interaction and hydrogen bonds. Our results showed that the obtained CPP/CS-rGO composite scaffolds exhibited highly improved biomineralization and considerable antibacterial activity. More importantly, CPP/CS-rGO composite scaffolds could drive osteogenic differentiation of BMSCs and significantly up-regulate the expression of osteogenesis-related proteins in vitro. Meanwhile, the CS-rGO coating could inhibit aseptic loosening and improve interfacial osseointegration through stimulating BMSCs to secrete more OPG and lesser RANKL. Overall, the CS-rGO coating adjusts CPP scaffolds’ biological environment interface and endows CPP scaffolds with more bioactivity.

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Section: Biomineralizationmentioning

confidence: 82%

The construction of a self-assembled coating with chitosan-grafted reduced graphene oxide on porous calcium polyphosphate scaffolds for bone tissue engineering

Ding¹,

Xu²,

Hu³

et al. 2022

Biomed. Mater.

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“…After incubation with SBF for 7 days, more mineralized deposits were observed on the surface of SCPP/MoS 2 and SCPP/MoS 2 -MET than that on the surface of SCPP (Figure e). The ability of MoS 2 -modified SCPP to promote mineralization might be due to the large negative surface charge of MoS 2 , , which attracted Ca 2+ for deposition through electrostatic gravity . To further characterize the sediment, we determined the atomic ratios of calcium and phosphorus elements on the surface of scaffold-samples by using EDS mapping (Figure S5).…”

Section: Resultsmentioning

confidence: 99%

3D Molybdenum Disulfide Nanospheres Loaded with Metformin to Enhance SCPP Scaffolds for Bone Regeneration

Luo,

Peng,

Cheng

et al. 2023

ACS Appl. Mater. Interfaces

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Conventional strontium-doped calcium polyphosphate (SCPP) ceramics have attracted a lot of attention due to good cytocompatibility and controlled degradation. However, their poor mechanical strength, brittleness, and difficulty in eliminating unavoidable postoperative inflammation and bacterial infections in practical applications limit their further clinical application. In this study, carboxylated molybdenum disulfide nanospheres (MoS 2 − COOH) were first prepared via a one-step hydrothermal method. The optimal doping concentration of MoS 2 −COOH was then incorporated into SCPP to overcome its poor mechanical strength. To further enhance the anti-inflammatory properties of scaffolds, metformin (MET) was loaded onto MoS 2 −COOH through covalent bond cross-linking (MoS 2 -MET). Then MoS 2 -MET was doped into SCPP (SCPP/MoS 2 -MET) according to the previously obtained concentration, resulting in the controlled and sustained release of MET from the SCPP/MoS 2 -MET scaffolds for 21 days in vitro. The SCPP/MoS 2 -MET scaffolds were shown to have good biological activity in vitro to promote stem cell proliferation and the potential to promote mineralization in vitro. It also showed good osteoimmunomodulatory activity could reduce the expression of proinflammatory factors and effectively induce the differentiation of BMSCs under inflammatory conditions, upregulating the expression of relevant osteoblastic cytokines. In addition, SCPP/MoS 2 -MET scaffolds could effectively inhibit Staphylococcus aureus and Escherichia coli. In vivo experiments also demonstrated better osteogenic potential of SCPP/MoS 2 -MET scaffolds compared with the other scaffold-samples. Thus, the introduction of carboxylated molybdenum disulfide nanospheres is a promising approach to improve the properties of SCPP and may provide a new modification strategy for inert ceramic scaffolds and the construction of multifunctional composite scaffolds for bone tissue engineering.

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“…Non-degradable (PE, PTFE, PMA, PAA, PU, polyether, poly-siloxanes, etc.) [10], [11] (Co-Cr, Ti, Ti-6Al-4V, stainless steel etc.) Application in orthopedics and dentistry Hearing aids (artificial)…”

Section: Snomentioning

confidence: 99%

Critical Review on 3D Scaffolds Materials

Yadav

Awasthi

Saxena

et al. 2022

MSF

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New strategies have been developed to design advanced functional biomimetic structures. This paper reviewed the benefits and drawbacks of biomaterials that are used to manufacture 3D scaffolds in tissue engineering. In this paper, latest technological methods, scaffold requirements in development of single form, composite form and cell-laden based scaffolds, classification on the basis of geometry and main material is explained elaborately. These scaffolds promote different molecules can be delivered to tissue and stimulate cell growth. These cells have a therapeutic effect. The paper discusses the various 3D bio printed structures and the difficulties they encounter. The impacts of biologically functionalized biomaterials on soft and hard tissue engineering in vitro and in vivo are discussed. The paper summarized the future prospects for bioactive scaffolds, that can be used in clinical therapy.

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Hydroxyapatite formation with the interface of chitin and chitosan

Cited by 8 publications

References 22 publications

The construction of a self-assembled coating with chitosan-grafted reduced graphene oxide on porous calcium polyphosphate scaffolds for bone tissue engineering

The construction of a self-assembled coating with chitosan-grafted reduced graphene oxide on porous calcium polyphosphate scaffolds for bone tissue engineering

3D Molybdenum Disulfide Nanospheres Loaded with Metformin to Enhance SCPP Scaffolds for Bone Regeneration

Critical Review on 3D Scaffolds Materials

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