Hydroxyapatite crystals as a bone graft substitute in benign lytic lesions of bone

Abstract

Background:Bone grafts are required to fill a cavity created after curettage of benign lytic lesions of the bone. To avoid the problems associated at donor site with autologous bone graft, we require allograft or bone graft substitutes. We evaluated the healing of lytic lesions after hydroxyapatite (HA) grafting by serial radiographs.Materials and Methods:Forty cases of benign lytic lesions of bone were managed by simple curettage and grafting using HA blocks. Commercially available HA of bovine origin (Surgiwear Ltd., Shahjahanpur, India) was used for this purpose. Mean duration of followup was 34.8 months (range 12–84 months). Mean patient age was 19.05 years (range 3–55 years). Radiological staging of graft incorporation was done as per criteria of Irwin et al. 2001.Results:In our series, two cases were in stage I. A total of 11 cases were in stage II and 27 were in stage III. Graft incorporation was radiologically complete by 15 months. Clinical recovery was observed before radiological healing. The average time taken to return to preoperative function was 3 months. Recurrence was observed in giant cell tumor (n = 3) and chondromyxoid fibroma (n = 1). There was no incidence of graft rejection, collapse, growth plate disturbances or antigenic response.Conclusions:We conclude that calcium HA is biologically acceptable bone graft substitute in the management of benign lytic lesions of bone.

Bone grafts in dentistry: A case report of migration of bone graft material

“…This widens its uses and applications such as being able to use it as a coating around dental implants 19 . It was previously derived from natural sources such as coral or bovine, although this is becoming less frequent due to factors such as dietary or religious objections, concurrently the ease of production of HA synthetically 23 …”

“…19 It was previously derived from natural sources such as coral or bovine, although this is becoming less frequent due to factors such as dietary or religious objections, concurrently the ease of production of HA synthetically. 23 Clear records of the original procedure undertaken in 1985 and subsequent revisions allowed for a clearer understanding of the patients dental and maxillofacial journey. This was important when attempting to understand the case including the reason for the wire placement that was protruding on presentation, what procedures the patient had already undergone, including complications as well as…”

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

“…Hydroxyapatite is major component (Figure ) of natural bone. It can be used to prepare matrix for bone implants . HA is synthesized via wet chemical precipitation, biomimetic deposition, or elecrodeposition .…”

“…It can be used to prepare matrix for bone implants. 85 HA is synthesized via wet chemical precipitation, biomimetic deposition, or elecrodeposition. 86,87 HA structure is based on calcium phosphate having good biocompatibility, osteoconductivity, and bioactivity, high rigidity, and low elasticity.…”