Hydroxyapatite-collagen nanoparticles reinforced polyanhydride based injectable paste for bone substitution: effect of dopant addition <i>in vitro</i>

Dasgupta, Sudip; Mondal, Soumini; Ray, Sambit; Singh, Yogendra Pratap; Maji, Kanchan

doi:10.1080/09205063.2021.1916867

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…This section describes the physical, mechanical, biological, cytotoxic, and antibacterial properties of the coated binary-doped HAp Doping with binary or multiple ions can affect various physical properties, such as the phase, crystallinity, mechanical properties, and lattice parameters of a material [121]. After being coated in doped HAp, the physical features of biomedical implants, such as phase and surface porosity, change [122]. This is because the plasma temperature, interactions with the substrate and spraying circumstances all play a role in this transformation.…”

Section: Effects Of Binary Doped Hapmentioning

confidence: 99%

Consequences of hydroxyapatite doping using plasma spray to implant biomaterials

Mehta

Singh

2023

J. Electrochem. Sci. Eng.

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Hydroxyapatite (HAp) is still one of the most common bioactive coatings used on metal implants in orthopaedics due to its biocompatibility. The application of HAp to metallic implants can be accomplished using a variety of processes. Plasma spray (PS) coating stands out as the method of choice due to its dependability, affordability, and ability to protect metal surfaces against rust and wear. The use of HAp in medicine has been limited due to the material's unfavorable mechanical characteristics, such as brittleness, a lack of fracture toughness, and inadequate tensile strength. In addition, the remodeling durations of HAp-covered implants are significantly longer, the rate of osseointegration is significantly lower, and no antimicrobial actions or features are present in these implants. The mechanical and biological properties of HAp have been improved by applying various approaches, all of which fall under the category of surface modification tactics. Dopants are one of those strategies that are extremely successful at changing the characteristics and using them in HAp is one of those methods. As a result, this review study aims to consolidate data on implant Hap coating using the plasma spray approach and assess the benefits and problems associated with employing this method. In addition, the paper addresses how altering the structural, chemical, and mechanical features of HAp can assist in overcoming these limitations. In conclusion, it explains how the incorporation of entering the HAp structure can change the features that, when coated using the plasma spraying approach, alter the functionality of the implant.

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Section: Effects Of Binary Doped Hapmentioning

confidence: 99%

Consequences of hydroxyapatite doping using plasma spray to implant biomaterials

Mehta

Singh

2023

J. Electrochem. Sci. Eng.

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“…For example, Sudip et al reported the hydroxyapatite-collagen nanoparticles incorporated cross-linked PA pasty formulations for the bone regeneration capacity in vitro. ( 96 ) The PA-nanoparticle blends were synthesized based on the radical medicated photopolymerization between the monomers of methacrylated SA and CPH in the presence Si and Sr doped hydroxyapatite-collagen nanoparticles. Blending of the nanoparticles to the extent of 10 wt % into PA matrix improves the compressive strength of the hardened paste from 30 to 49 MPa.…”

Section: Classificationmentioning

confidence: 99%

Polyanhydride Chemistry

Reddy

Domb

2022

Biomacromolecules

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Polyanhydrides (PAs) are a class of synthetic biodegradable polymers employed as controlled drug delivery vehicles. They can be synthesized and scaled up from low-cost starting materials. The structure of PAs can be manipulated synthetically to meet desirable characteristics. PAs are biocompatible, biodegradable, and generate nontoxic metabolites upon degradation, which are easily eliminated from the body. The rate of water penetrating into the polyanhydride (PA) matrix is slower than the anhydride bond cleavage. This phenomenon sets PAs as "surface-eroding drug delivery carriers." Consequently, a variety of PA-based drug delivery carriers in the form of solid implants, pasty injectable formulations, microspheres, nanoparticles, etc. have been developed for the sustained release of small molecule drugs, and vaccines, peptide drugs, and nucleic acid-based active agents. The rate of drug delivery is often controlled by the polymer erosion rate, which is influenced by the polymer structure and composition, crystallinity, hydrophobicity, pH of the release medium, device size, configuration, etc. Owing to the above-mentioned interesting physicochemical and mechanical properties of PAs, the present review focuses on the advancements made in the domain of synthetic biodegradable biomedical PAs for therapeutic delivery applications. Various classes of PAs, their structures, their unique characteristics, their physicochemical and mechanical properties, and factors influencing surface erosion are discussed in detail. The review also summarizes various methods involved in the synthesis of PAs and their utility in the biomedical domain as drug, vaccine, and peptide delivery carriers in different formulations are reviewed.

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Fabrication and investigation of physicochemical and biological properties of3Dprinted sodium alginate‐chitosan blend polyelectrolyte complex scaffold for bone tissue engineering application

Singh

Pramanik

2023

J of Applied Polymer Sci

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In tissue engineering technique, a biological scaffold with appropriate composition and structure for promoting growth and differentiation of cells thereby regenerating damaged tissue, is a prime necessity. In this paper, 3D‐printed scaffolds comprising sodium alginate (SA) and chitosan (CH) biopolymers of natural origin are reported. Bioinks with varying ratios of SA and CH were prepared and scaffolds were fabricated by 3D printing. The fabricated scaffolds possess many desired properties that are vital for tissue regeneration purposes. The scaffolds possess open pore microstructures with interconnected pores and desired pore size as revealed by scanning electron microscopic image analysis. The polyelectrolyte complex formation (PEC) between SA and CH as revealed by Fourier‐transform‐infrared spectroscopic analysis is favorable as it offers a better surface for cell attachment and proliferation, and an ideal microenvironment for bone regeneration. Among the scaffolds, SA/CH with 60:40 showed controlled swelling and degradation behavior, with higher tensile strength of 0.387 ± 0.015 MPa. In vitro‐biomineralization showed superior apatite layer deposition ability over the SA/CH: 60/40 scaffold surface. The fabricated SA/CH scaffolds are hydrophilic and biocompatible as evident from the contact angle, protein adsorption, MTT assay, and cell attachment studies. However, SA/CH: 60/40 is shown to have superior biological properties compared with the other SA/CH compositions. Thus, it is concluded that 3Dv printed SA/CH: 60/40 scaffold having some superior properties and bioactivity can be used as a suitable matrix for future bone tissue regeneration applications.

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Hydroxyapatite-collagen nanoparticles reinforced polyanhydride based injectable paste for bone substitution: effect of dopant addition in vitro

Cited by 8 publications

References 29 publications

Consequences of hydroxyapatite doping using plasma spray to implant biomaterials

Consequences of hydroxyapatite doping using plasma spray to implant biomaterials

Polyanhydride Chemistry

Fabrication and investigation of physicochemical and biological properties of3Dprinted sodium alginate‐chitosan blend polyelectrolyte complex scaffold for bone tissue engineering application

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