Hydroxyapatite/collagen composite materials formation in simulated body fluid environment

Zhang, Lijuan; Feng, Xi; Liu, Hong-Guo; Qian, Dong−Jin; Zhang, Li; Yu, Xiaohong; Cui, Fuzhai

doi:10.1016/j.matlet.2003.07.009

Cited by 119 publications

(56 citation statements)

References 21 publications

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“…A semi-crystalline standard was observed for BC and a broad peak at the 2θ range 10°-25° was verified for the diffraction pattern of collagen (Figure 3b), whose characteristic is typical of pure collagen. All such features proved collagen a quite amorphous polymer 31 .…”

Section: X-ray Diffraction (Xrd)mentioning

confidence: 90%

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Moraes¹,

et al. 2016

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This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed -Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.

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Section: X-ray Diffraction (Xrd)mentioning

confidence: 90%

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Moraes¹,

et al. 2016

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“…These observations confirm that HA crystals were prepared, partially substituted by -CO 3 2-groups. Therefore, HA crystals are CO 3 2-containing HA [24]. Also the broad bands at about 3200 and 2800 cm -1 , correspond to the absorbed hydrate and the sharp medium and short peaks between 3570-3670 cm -1 belong to the stretching vibrations of lattice OH -ions of hydroxyapatite [25].…”

Section: Ftir-studiesmentioning

confidence: 93%

Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: Correlation with biocompatibility aspects

Bundela¹,

Bajpai²

2008

Express Polym. Lett.

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In the present study polyacrylamide (PAm)-gelatin-hydroxyapatite (HA) composites have been synthesized by suspension polymerization method. The prepared composites were characterized by Fourier transform spectroscopy (FTIR) which revealed the presence of functional groups in the composite. The X-ray diffraction (XRD) studies indicated that HA powder was present in nano size. Thermogravimetric analysis (TGA) revealed that composite is more thermally stable than the polymer matrix alone. The morphology of composite studied by optical microscopy (OPM) and scanning electron microscopy (SEM) suggested that pore size was between 3–20 µm. The composites showed adequately good mechanical properties as evident from the varying compressive strength and modulus in the range 31.57±8.16 MPa and 745±388 MPa, respectively. The water sorption behavior was found to be dependent on the chemical composition of the matrix and the sorption data were used to calculate network parameters. The porosity of composite varied between 4 to 30.66%.The in vitro blood compatibility indicated that the adsorption of bovine serum albumin (BSA) varied from 0.11 to 0.24 mg•g–1, the percentage haemolysis was between 2.4 to 6.9% and the weight of blood clot formed on the composite surfaces were found in the range 11 to 52 mg

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“…As a consequence, cations that act as counter-ions to acidic silanol groups will be eliminated from the silica phase. The latter process could proceed in association with a cation exchanger, perhaps collagen carrying negatively charged residue groups (aspartate and glutamate), at a slightly increased pH milieu (Zhang et al, 2004). A recent study provided experimental evidence that the hardness of the biosilica within the M. chuni GBS is regionally different (Miserez et al, 2008); by focusing on the axial cylinder, Miserez et al found that the hardness/indentation of the center of the spicules is approximately 2.5 times lower compared with the lamellar region.…”

Section: Discussionmentioning

confidence: 99%

Circumferential spicule growth by pericellular silica deposition in the hexactinellid sponge Monorhaphis chuni

Wang

Wiens

Schröder

et al. 2011

Journal of Experimental Biology

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SUMMARYThe giant basal spicule of the hexactinellid sponge Monorhaphis chuni represents the longest natural siliceous structure on Earth. This spicule is composed of concentrically arranged lamellae that are approximately 10m thick. In the present study, we investigated the formation of outer lamellae on a cellular level using microscopic and spectroscopic techniques. It is shown that the formation of an outermost lamella begins with the association of cell clusters with the surface of the thickening and/or growing spicule. The cells release silica for controlled formation of a lamella. The pericellular (silica) material fuses to a delimited and textured layer of silica with depressions approximately 20-30m in diameter. The newly formed layer initially displays 40m wide, well-structured banded ribbons and only attains its plain surface in a final step. The chemical composition in the depressions was studied using energy dispersive X-ray spectroscopy and by staining with Texas Red. The data suggest that those depressions are the nests for the silica-forming cells and that silica formation starts with a direct association of silicaforming cells with the outer surface of the spicule, where they remain and initiate the development of the next lamellae.

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Hydroxyapatite/collagen composite materials formation in simulated body fluid environment

Cited by 119 publications

References 21 publications

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: Correlation with biocompatibility aspects

Circumferential spicule growth by pericellular silica deposition in the hexactinellid sponge Monorhaphis chuni

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