Hydroxyapatite coating on titanium endosseous implants for improved osseointegration: Physical and chemical considerations

Łukaszewska-Kuska, Magdalena; Krawczyk, Piotr; Martyła, Agnieszka; Hędzelek, Wiesław; Dorocka‐Bobkowska, Barbara

doi:10.17219/acem/69084

Cited by 34 publications

(24 citation statements)

References 24 publications

(39 reference statements)

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“…Recently, we presented a modified electrochemical method of coating titanium implants with HA. 5 The obtained coating was found to be highly pure, homogenous HA, which was uniform, crack-free and thin. Moreover, its moderate surface roughness and coatings crystallinity was potentially conducive to tissue reaction.…”

Section: Introductionmentioning

confidence: 89%

“…Hydroxyapatite (HA) has been used for many years as a bioactive implant coating to improve osseointegration. [5][6][7] It has a large capacity for adsorbing proteins, improves osteoblast proliferation, enhances bone formation, and reduces bone loss. [8][9][10] These properties induce a more rapid fixation and stronger bonding between the host bone and the implant and are conducive to uniform bone ingrowth at the bone-implant interface.…”

Section: Introductionmentioning

confidence: 99%

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Effects of a hydroxyapatite coating on the stability of endosseous implants in rabbit tibiae

Łukaszewska-Kuska¹,

Krawczyk²,

Martyła³

et al. 2019

Dent. Med. Probl.

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Background. A dental implant surface which would promote rapid and strong osseointegration is a key factor of success in modern implantology. To achieve this goal, different implant surface modifications are developed. A hydroxyapatite (HA) coating changing a bioinert titanium surface into bioactive is one of them. Objectives. The objective of the study was to investigate the effects on bone osseointegration in rabbits resulting from the application of a HA coating deposited on titanium endosseous implants using a modified electrochemical method. Material and methods. Titanium implants with HA coatings and controls with Al 2 O 3 grit-blasted surfaces were embedded into rabbit tibiae. The chemical composition, roughness and morphology of the implants were determined. Implant stability tests were performed, and the Periotest ® value (PTV) and the implant stability quotient (ISQ) value for Osstell Mentor were recorded in order to evaluate the osseointegration. Results. The surface characterization of the implants revealed a microstructure with an arithmetical mean height (Sa) in the range of 0.71-1.04 µm. The HA coating was free of contamination, whereas the controls were enriched with corundum. After healing, a statistically significant increase in the mean ISQ and a decrease in the mean PTV for the HA-coated implants was observed. In the case of the control implants, only PTV decreased significantly with time. Conclusions. The present study found that implant surface properties affected implant stability as determined by Osstell and Periotest measurements. The HA coating reported herein was found to have chemical and physical properties which appear to improve osseointegration compared to grit-blasted implants.

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Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effects of a hydroxyapatite coating on the stability of endosseous implants in rabbit tibiae

Łukaszewska-Kuska¹,

Krawczyk²,

Martyła³

et al. 2019

Dent. Med. Probl.

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“…One of strategies is to implant surface modification by inorganic coatings, like calcium phosphates (CaP) or hydroxyapatite (HA), that represent inorganic phase of the natural bone [ 1 , 2 , 4 , 7 , 8 , 9 , 10 , 11 , 12 ]. HA-based coatings on the titanium implants are responsible for osteoconductivity, bioactivity, and stability of the bone/implant connection.…”

Section: Introductionmentioning

confidence: 99%

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

et al. 2020

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Organophosphorus compounds, like bisphosphonates, drugs for treatment and prevention of bone diseases, have been successfully applied in recent years as bioactive and osseoinductive coatings on dental implants. An integrated experimental-theoretical approach was utilized in this study to clarify the mechanism of bisphosphonate-based coating formation on dental implant surfaces. Experimental validation of the alendronate coating formation on the titanium dental implant surface was carried out by X-ray photoelectron spectroscopy and contact angle measurements. Detailed theoretical simulations of all probable molecular implant surface/alendronate interactions were performed employing quantum chemical calculations at the density functional theory level. The calculated Gibbs free energies of (TiO2)10–alendronate interaction indicate a more spontaneous exergonic process when alendronate molecules interact directly with the titanium surface via two strong bonds, Ti–N and Ti–O, through simultaneous participation common to both phosphonate and amine branches. Additionally, the stability of the alendronate-modified implant during 7 day-immersion in a simulated saliva solution has been investigated by using electrochemical impedance spectroscopy. The alendronate coating was stable during immersion in the artificial saliva solution and acted as an additional barrier on the implant with overall resistivity, R ~ 5.9 MΩ cm2.

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“…The subsequent immersion of the modified substrates in simulated body fluid (SBF) leads to the transformation of the amorphous CaP coating into a crystalline CaP coating [29,31]. Application of chemical pretreatment, like acid, alkaline or acid–alkaline treatment (AAT), may advantageously influence the outcome of the ECD process [48,49,50,51,52,53].…”

Section: Introductionmentioning

confidence: 99%

Native Osseous CaP Biomineral Coating on a Biomimetic Multi-Spiked Connecting Scaffold Prototype for Cementless Resurfacing Arthroplasty Achieved by Combined Electrochemical Deposition

et al. 2019

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The multi-spiked connecting scaffold (MSC-Scaffold) prototype with spikes mimicking the interdigitations of articular subchondral bone is an essential innovation in surgically initiated fixation of resurfacing arthroplasty (RA) endoprosthesis components. This paper aimed to present a determination of the suitable range of conditions for the calcium phosphate (CaP) potentiostatic electrochemical deposition (ECDV=const) on the MSC-Scaffold prototype spikes to achieve a biomineral coating with a native Ca/P ratio. The CaP ECDV=const process on the MSC-Scaffold Ti4Al6V pre-prototypes was investigated for potential VECDfrom −9 to −3 V, and followed by 48 h immersion in a simulated body fluid. An acid–alkaline pretreatment (AAT) was applied for a portion of the pre-prototypes. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD) studies of deposited coatings together with coatings weight measurements were performed. Themost suitable VECD range, from −5.25 to −4.75 V, was determined as the native biomineral Ca/P ratio of coatings was achieved. AAT increases the weight of deposited coatings (44% for VECD = −5.25 V, 9% for VECD = −5.00 V and 15% for VECD = −4.75 V) and the coverage degree of the lateral spike surfaces (40% for VECD = −5.25 V, 14% for VECD = −5.00 V and 100% for VECD = −4.75 V). XRD confirmed that the multiphasic CaP coating containing crystalline octacalcium phosphate is produced on the lateral surface of the spikes of the MSC-Scaffold. ECDV=const preceded by AAT prevents micro-cracks on the bone-contacting surfaces of the MSC-Scaffold prototype, increases its spikes’ lateral surface coverage, and results in the best modification effect at VECD = −5.00 V. To conclude, the biomimetic MSC-Scaffold prototype with desired biomineral coating of native Ca/P ratio was obtained for cementless RA endoprostheses.

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Hydroxyapatite coating on titanium endosseous implants for improved osseointegration: Physical and chemical considerations

Abstract: The coating reported herein was found to have potentially favorable chemical and physical characteristics fostering osseointegration.

Cited by 34 publications

References 24 publications

Effects of a hydroxyapatite coating on the stability of endosseous implants in rabbit tibiae

Effects of a hydroxyapatite coating on the stability of endosseous implants in rabbit tibiae

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

Native Osseous CaP Biomineral Coating on a Biomimetic Multi-Spiked Connecting Scaffold Prototype for Cementless Resurfacing Arthroplasty Achieved by Combined Electrochemical Deposition

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