Hydroxyapatite Coating on TiO₂ Nanotube by Sol–Gel Method for Implant Applications

Abstract

The aim of this study was to determine the effect of hydroxyapatite (HA) coating on titanium dioxide (TiO2) nanotube by sol-gel process on viability of osteoblast like cell (MC3T3-E1) and bone formation in rat tibia. Specimens were divided into three groups including commercially pure titanium (control group), TiO2 nanotubes (group N), and HA coated TiO2 nanotubes (group HN). Surface characteristics were determined using field emission scanning electron microscope (FE-SEM; S-4700, Hitachi, Japan) and contact angles were measured. Cell viability was investigated in vitro after 1 day, 3 days, and 7 days of incubation. Implants (2.0 mm in diameter and 5.0 mm in length) were inserted into the tibia of rats. After 4 weeks, histomorphometric analysis was performed. Both N and HN groups showed enhanced hydrophilicity compared to control group. After 7 days of implantation, group HN showed higher cell viability with marginal significance (0.05 < P < 0.1). Bone to implant contact (BIC) ratio in the control group, group N, and group HN were 32.5%, 33.1%, and 43.8%, respectively. Results of this study showed that HA coated TiO2 nanotube using sol-gel process could be used to enhance hydrophilicity and improve osseointegration of dental implant surface.

Optimization of Energy and Time Variations for Synthesis of N doped TiO2 Nanotube using Microwave-Asssisted Hydrothermal Method

“…The nano form used in this research is nanotubes. The synthesis of nitrogen-doped TiO2 in the form of nanotubes can be carried out by several methods including sol-gel (Lim et al, 2018), hydrothermal (Lee et al, 2011), anodization (Yoriya, 2014), and microwave hydrothermal (Huy et al, 2011 andGyawali, 2016).…”