Hydroxyapatite coating on PEEK implants: Biomechanical and histological study in a rabbit model

Durham, John; Montelongo, Sergio; Ong, Joo L.; Guda, Teja; Allen, Matthew J.; Rabiei, Afsaneh

doi:10.1016/j.msec.2016.06.049

Cited by 65 publications

(57 citation statements)

References 30 publications

(36 reference statements)

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“…), or to mix these polymers with bioactive materials (e.g., bioactive glass, hydroxyapatite, β-TCP, calcium silicate, etc.) [3][4][5][6]. The main problem of coatings is to guarantee a proper adhesion to the polymeric surface.…”

Section: Introductionmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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Polymers are materials widely used in biomedical science because of their biocompatibility, and good mechanical properties (which, in some cases, are similar to those of human tissues); however, these materials are, in general, chemically and biologically inert. Surface characteristics, such as topography (at the macro-, micro, and nano-scale), surface chemistry, surface energy, charge, or wettability are interrelated properties, and they cooperatively influence the biological performance of materials when used for biomedical applications. They regulate the biological response at the implant/tissue interface (e.g., influencing the cell adhesion, cell orientation, cell motility, etc.). Several surface processing techniques have been explored to modulate these properties for biomedical applications. Despite their potentials, these methods have limitations that prevent their applicability. In this regard, laser-based methods, in particular laser surface texturing (LST), can be an interesting alternative. Different works have showed the potentiality of this technique to control the surface properties of biomedical polymers and enhance their biological performance; however, more research is needed to obtain the desired biological response. This work provides a general overview of the basics and applications of LST for the surface modification of polymers currently used in the clinical practice (e.g., PEEK, UHMWPE, PP, etc.). The modification of roughness, wettability, and their impact on the biological response is addressed to offer new insights on the surface modification of biomedical polymers.

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Section: Introductionmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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“…However, PK is a bioinert material that does not promote cell adhesion and growth, and PK implants can barely bind to host bone directly, which impedes the use of PK in clinical treatments 16 .…”

Section: Discussionmentioning

confidence: 99%

Influences of surface treatments with abrasive paper and sand-blasting on surface morphology, hydrophilicity, mineralization and osteoblasts behaviors of n-CS/PK composite

Tang

Huang

Dai

et al. 2017

Sci Rep

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The surfaces of nano-calcium silicate (n-CS)/polyetheretherketone (PK) composites were treated with abrasive paper and sand-blasting, and the surfaces performances of the as-treated composites were studied. The results showed that the surface roughness, hydrophilicity and mineralization of the simulated body fluid (SBF) of the composites surfaces were significantly improved, and the properties of the composites treated by with sand-blasting were better than those treated with abrasive paper. Moreover, the treated composites significantly promoted osteoblasts responses, such as cell attachment, spreading, proliferation and alkaline phosphatase (ALP) activity, compared to un-treated composites, and the cellular responses to the composites treated with sand-blasting were better than those treated with abrasive paper. The results suggested that surface treatment with sand-blasting was an effective method to greatly improve the surface bioperformances of the n-CS/PK composite, and this treated composite with improved bioactivity and cytocompatibility might be a promising implant material for orthopedic applications.

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“…Since Ti/YSZ expand differently compared to PEEK at high temperatures (as autoclaving) a heat treatment was required to evaluate any signs of coating de-attachments. Studies have shown that a heat treatment after Ti/YSZ and HA deposition, decreases the bonding strength to the PEEK surface and delamination was found in those studies performing pull-out tests 198,[247][248][249] . The produced layer of HA with this technique was amorphous which may cause a more rapid dissolution.…”

Section: Micro-ct Resultsmentioning

confidence: 99%

“…This occurrence has been detected by other authors. Studies have concluded that a smooth (Sa ≤ 0.2 µm) underlying surface of the implant shows lower BIC after a longer healing time compared to rougher surfaces 247,279 . However, using a smooth surface enables a more exclusive evaluation of the coating.…”

Section: Micro-ct Resultsmentioning

confidence: 99%

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On hydroxyapatite modified peek implants for bone applications

Johansson¹

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Polyether ether ketone (PEEK) has been frequently used in spinal surgery with good clinical results. The material has a low elastic modulus and is radiolucent. However, in oral implantology PEEK has displayed inferior ability to osseointegrate compared to titanium materials. One idea to reinforce PEEK would be to coat it with hydroxyapatite (HA), a ceramic material of good biocompatibility. In the present study we analyzed HA-coated PEEK tibial implants via histology and radiography when following up at 3 and 12 weeks. Of the 48 implants, 24 were HA-coated PEEK screws (test) and another 24 implants served as uncoated PEEK controls. HA-coated PEEK implants were always osseointegrated. The total bone area (BA) was higher for test compared to control implants at 3 (p < 0.05) and 12 weeks (p < 0.05). Mean bone implant contact (BIC) percentage was significantly higher (p = 0.024) for the test compared to control implants at 3 weeks and higher without statistical significance at 12 weeks. The effect of HA-coating was concluded to be significant with respect to early bone formation, and HA-coated PEEK implants may represent a good material to serve as bone anchored clinical devices.

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Hydroxyapatite coating on PEEK implants: Biomechanical and histological study in a rabbit model

Cited by 65 publications

References 30 publications

Laser Surface Texturing of Polymers for Biomedical Applications

Laser Surface Texturing of Polymers for Biomedical Applications

Influences of surface treatments with abrasive paper and sand-blasting on surface morphology, hydrophilicity, mineralization and osteoblasts behaviors of n-CS/PK composite

On hydroxyapatite modified peek implants for bone applications

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