Hydroxyapatite-based composites: Excellent materials for environmental remediation and biomedical applications

Verma, Rajkumar; Mishra, Soumya Ranjan; Gadore, Vishal; Ahmaruzzaman, Md.

doi:10.1016/j.cis.2023.102890

Cited by 53 publications

(16 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydroxyapatite (HA) consists of 18.5% P, 39% Ca, and 3.38% hydroxyl groups (OH) by weight. 50% of the bone weight is composed of HA, which has high biocompatibility and osteogenic activity. , The porous property of HA has high binding affinity for various pharmacological substances such as antibody fragments, enzymes, hormones, antibiotics, and steroids. − These properties increase the likelihood that HA will deliver pharmacological substances.…”

Section: Surface Modification Substance Coatingsmentioning

confidence: 99%

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Bai,

Zhao,

Cui

et al. 2024

ACS Omega

View full text Add to dashboard Cite

Implant-associated infections and the increasing number of bone implants loosening and falling off after implantation have become urgent global challenges, hence the need for intelligent alternative solutions to combat implant loosening and falling off. The application of polyetheretherketone (PEEK) in biomedical and medical therapy has aroused great interest, especially because its elastic modulus close to bone provides an effective alternative to titanium implants, thereby preventing the possibility of bone implants loosening and falling off due to the mismatch of elastic modulus. In this Review, we provide a comprehensive overview of recent advances in surface modifications to prevent bone binding deficiency and bacterial infection after implantation of bone implants, starting with inorganics for surface modification, followed by organics that can effectively promote bone integration and antimicrobial action. In addition, surface modifications derived from cells and related products of biological activity have been proposed, and there is increasing evidence of clinical potential. Finally, the advantages and future challenges of surface strategies against medical associated poor osseointegration and infection are discussed, with promising prospects for developing novel osseointegration and antimicrobial PEEK materials.

show abstract

Section: Surface Modification Substance Coatingsmentioning

confidence: 99%

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Bai,

Zhao,

Cui

et al. 2024

ACS Omega

View full text Add to dashboard Cite

show abstract

“…Chemical agents like potassium hydroxide, phosphoric acid, or malic acid can be applied to the raw materials or introduced during pyrolysis to create modified biochar with increased adsorption efficiency for removing contaminants [123,124]. Researchers showed that subjecting the biochar, along with the KOH blend, to pyrolysis at temperatures ranging from 350 to 550°C reopened some of its blocked pores and widened the smaller pore sizes, resulting in increased surface area [125]. Tabassam et al utilized rice husk-derived biochar modified with cinnamic acid.…”

Section: Acid-alkaline Modified Biocharmentioning

confidence: 99%

Advancements in application of modified biochar as a green and low-cost adsorbent for wastewater remediation from organic dyes

Hama Aziz,

Fatah,

Muhammad

2024

R. Soc. Open Sci.

View full text Add to dashboard Cite

Synthetic organic dyes, which are resistant to biodegradation, pose a notable health risk, potentially leading to cancer and respiratory infections. Researchers have addressed this concern by exploring physicochemical methods to remove organic dyes from wastewater. A particularly promising solution involves modified biochar adsorbents, which demonstrate high efficiency in organic dye removal. Biochar, a charcoal-like material derived from biomass pyrolysis, offers advantages such as low cost, eco-friendliness, high efficiency and reusability. Beyond its role in sustainable soil remediation, biochar proves effective in removing organic dyes from wastewater after undergoing physical or chemical modification. Acid–base activation or metal–heteroatom impregnation enhances biochar's adsorption capacity. This comprehensive review examines the attributes of biochar, common methods for production and modification, and the impacts of raw materials, pyrolysis temperature, heating rate and residence time. It further elucidates the biochar adsorption mechanism in the removal of organic dyes, assessing factors influencing efficiency, including biochar feedstock, solution pH, adsorption temperature, particle size, initial dye concentration, biochar dosage and reaction time. It explores challenges, opportunities, reusability and regeneration methods of biochar in treating organic dye wastewater. It also discusses recent advances in organic dye removal using adsorption-based biochar. The review ultimately advocates for enhancing biochar's adsorption performance through post-modification.

show abstract

“…Hydroxyapatite, which is a natural component of bones and teeth, is the material of choice for different types of delivery systems (eg, nanoparticles, thin films on prostheses, cements, etc.) used for bone infection treatment, [61][62][63][64][65][66][67][68][69] while ciprofloxacin is one of the most commonly used antibiotics to treat osteomyelitis (bone infection). Osteomyelitis, if not properly treated, can leave bone permanently damaged.…”

Section: Dovepressmentioning

confidence: 99%

“…Hydroxyapatite (HA) is one of the most studied biomaterials and has been used as a drug and protein carrier, which has been summarized in recent reviews. [61][62][63][64] Hybrid structures with HA as an inorganic component and different organic molecules were described in. [65][66][67][68][69] However, to the best of our knowledge, this is the first paper presenting the synthesis of hybrid HA-BSA nanoflowers and studying their usage as drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Bovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin

Bobrowska,

Sadowska,

Stolarczyk

et al. 2023

IJN

View full text Add to dashboard Cite

Hybrid nanoflowers are structures consisting of organic (enzymes, proteins, nucleic acids) and inorganic components (mostly metal phosphates) with a flower-like hierarchical structure. Novel hybrid nanoflowers based on bovine serum albumin (BSA) and hydroxyapatite (HA) were obtained and characterized. Study on BSA-HA nanoflowers as potential drug delivery system is reported for the first time. Methods: Embedding ciprofloxacin in the structure of hybrid nanoflowers was confirmed by ATR-FTIR and thermogravimetric analysis. The inorganic phase of the nanoflowers was determined by X-ray diffraction. UV-Vis spectroscopy was used to evaluate the release profiles of ciprofloxacin from nanoflowers in buffer solutions at pH 7.4 and 5. The agar disk diffusion method was used to study the antibacterial activity of the synthesized nanoflowers against Staphylococcus aureus and Pseudomonas aeruginosa. Results: Bovine serum albumin -hydroxyapatite nanoflowers were obtained with diameters of ca. 1-2 µm. The kinetics of ciprofloxacin release from nanoflowers were described by the Korsmeyer-Peppas model. The antibacterial activity of the synthesized nanoflowers was demonstrated against S. aureus and P. aeruginosa, two main pathogens found in osteomyelitis. Conclusion:The formulated nanoflowers may act as an efficient local antibiotic delivery system. Due to the use of nonhazardous, biodegradable components and benign synthesis, hybrid nanoflowers are very promising drug delivery systems that could be applied in the treatment of skeletal system infections.

show abstract

Hydroxyapatite-based composites: Excellent materials for environmental remediation and biomedical applications

Cited by 53 publications

References 168 publications

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Advancements in application of modified biochar as a green and low-cost adsorbent for wastewater remediation from organic dyes

Bovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin

Contact Info

Product

Resources

About