Hydroxyapatite-based cements induce different apatite formation in radicular dentin

Zn-doping of silicate and hydroxyapatite-based cements: Dentin mechanobiology and bioactivity

“…Probably, the apical third of dentin is one of the regions more widely analyzed of the canal root (Toledano-Osorio et al, 2020a). The strains at the apical third of the root is proximately 3-and 6-fold greater than the strains at middle-root and cervical thirds, respectively (Brosh et al, 2018).…”

“…Equally, oxipatite helped for the highest maturity and organization of collagen, mainly supported on collagen, pyridinium, proteoglycans, amide III and ά-helices, at the apical section of dentin ) (Figure 5). The preferred grain orientation from polycrystalline lattices combined with amorphous structures is produced after treating apical dentin with oxipatite (Moshaverinia et al, 2008;Toledano-Osorio et al, 2020a). Apical dentin treated with oxipatite also attains favorable texture.…”

“…The amorphous HAp is linked to crystal imperfections in nano crystalline materials, small round crystallite size and lattice distortion with augmented microstrain. It is believed that zinc may have facilitated amorphous calcium phosphate stabilization, by performing as crystal growth inhibitor (Timlin et al, 2000) and providing both bioactivity and intrafibrillar mineralization (Toledano et al, 2015) (Figure S3) at the expenses of polyhedral apatite crystals (Toledano-Osorio et al, 2020a) (Figure 7).…”

“…At the same time, a reduction of the full width at half maximum (FWHM) of the phosphate peak at 960 cm -1 , i.e., higher crystallinity, at cervical dentin was determined and associated to an enhancement of mechanical performance. Crystallinity, wider and shorter crystallites, and maturity of the formed HAp are associated (Toledano-Osorio et al, 2020a). In order to avoid crack generation and transmission through the dentin substrate, an effective remineralizing approach would also involve the ability to absorb mechanical shock waves.…”

Doxycycline‐functionalized polymeric nanoparticles inhibit Enterococcus faecalis biofilm formation on dentine

“…To overcome these problems, it would be a powerful approach to incorporate substances into root canal sealers which are able to strengthen and prolong the antimicrobial effect, and also mechanically reinforce and remineralize root dentine (Baras et al 2019, Brezhnev et al . 2019, Toledano‐Osorio et al 2020a).…”