Hydroxyapatite as a biomaterial – a gift that keeps on giving

Ghiasi, Behrad; Sefidbakht, Yahya; Mozaffari‐Jovin, Sina; Gharehcheloo, Behnaz; Mehrarya, Mehrnoush; Khodadadi, Arash; Rezaei, Mohammad; Siadat, Seyed Omid Ranaei; Uskoković, Vuk

doi:10.1080/03639045.2020.1776321

Cited by 69 publications

(37 citation statements)

References 285 publications

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“…Even considering a possible experimental error obtained by a punctual analysis, such as that of EDS, Ca / P ratios (above 1.67) presented by the samples indicate the possibility of hydroxyapatite formation as a crystalline phase in these materials. 51,52 However, this is very interesting since values below 1.67, for example, can mean less stability hydroxyapatite phase.…”

Section: Glass-ceramic Bioactivitymentioning

confidence: 99%

Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li₂O·11.10ZrO₂·69.32SiO₂ glass–ceramic

et al. 2021

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Glass and bioactive glass–ceramic can be used in several applications. In bone growth where good bone/biomaterial adhesion was required, bioactive coatings for implants can improve bone formation. The glass and glass–ceramics of the LZS (Li2O‐ZrO2‐SiO2) system are very interesting because of their mechanical, electrical, and thermal properties. Very recently, their biological response in contact with human osteoblast has been evaluated. However, despite several initiatives, there are still no studies that systematically assess this system's bioactivity, dissolution, and cytotoxicity in vitro. This work aims to investigate the dissolution, bioactivity behavior, and cytotoxicity of LZS glass–ceramic. LZS glass–ceramics were produced from SiO2, Li2CO3, and ZrSiO4 by melting followed by quenching. The obtained glass frits were milled and uniaxially pressed and heat‐treated at 800 and 900°C and submitted to physical–chemical, structural and mechanical characterization. Their dissolution behavior was studied in Tris–HCl, while bioactivity was performed in simulated solution body fluid (SBF). The cytotoxicity test was performed using glass–ceramic in direct contact with mesenchymal stem/stromal cells (SC) isolated from human exfoliated deciduous teeth. Structural and microstructural analyzes confirmed bioactivity. The results show that it was possible to produce bioactive glass–ceramic from LZS, proven by the formation of new calcium phosphate structures such as hydroxyapatite on the surface of the samples after exposure to SBF. The SC viability test performed indicated that the materials were not cytotoxic at 0.25, 0.5, and 1.0 mg/ml. The glass–ceramic system under study is very promising for a medicinal application that requires bioactivity and/or biocompatibility for bone regeneration.

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Section: Glass-ceramic Bioactivitymentioning

confidence: 99%

Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li₂O·11.10ZrO₂·69.32SiO₂ glass–ceramic

et al. 2021

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“…Although HAp is characterized by superior cell uptake efficiencies and excellent biocompatibility and bioactivity profiles, one significant drawback of HAp as a drug delivery vehicle comes from its inability to entrap organic molecules, regardless of how small they get, inside its crystalline lattice [ 12 ]. Thanks to its “zwitterionic” alternation of highly charged divalent calcium ions and trivalent phosphates on the surface, HAp does have a propensity to bind organic molecules via physisorption [ 13 ], but such molecules tend to undergo a burst release soon after the contact of the particles with the solvent [ 14 ], thus disabling the sustained release, which is a sine qua non for most drug delivery carriers.…”

Section: Introductionmentioning

confidence: 99%

When Nothing Turns Itself Inside out and Becomes Something: Coating Poly(Lactic-Co-Glycolic Acid) Spheres with Hydroxyapatite Nanoparticles vs. the Other Way Around

Uskoković

Wu²

2022

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To stabilize drugs physisorbed on the surface of hydroxyapatite (HAp) nanoparticles and prevent burst release, these nanoparticles are commonly coated with polymers. Bioactive HAp, however, becomes shielded from the surface of such core/shell entities, which partially defeats the purpose of using it. The goal of this study was to assess the biological and pharmacokinetic effects of inverting this classical core/shell structure by coating poly(lactic-co-glycolic acid) (PLGA) spheres with HAp nanoparticles. The HAp shell did not hinder the release of vancomycin; rather, it increased the release rate to a minor degree, compared to that from undecorated PLGA spheres. The decoration of PLGA spheres with HAp induced lesser mineral deposition and lesser upregulation of osteogenic markers compared to those induced by the composite particles where HAp nanoparticles were embedded inside the PLGA spheres. This was explained by homeostatic mechanisms governing the cell metabolism, which ensure than the sensation of a product of this metabolism in the cell interior or exterior is met with the reduction in the metabolic activity. The antagonistic relationship between proliferation and bone production was demonstrated by the higher proliferation rate of cells challenged with HAp-coated PLGA spheres than of those treated with PLGA-coated HAp. It is concluded that the overwhelmingly positive response of tissues to HAp-coated biomaterials for bone replacement is unlikely to be due to the direct induction of new bone growth in osteoblasts adhering to the HAp coating. Rather, these positive effects are consequential to more elementary aspects of cell attachment, mechanotransduction, and growth at the site of contact between the HAp-coated material and the tissue.

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“…Hydroxyapatite (HA) is currently used in clinical oral surgery, especially in bone tissue regeneration, such as for the treatment of periodontal bone defects, filling bone defects following cyst removal and apicoectomies, or, in the case of dental implant removal, to increase the width of atrophic alveolar ridges. Additionally, hydroxyapatite scaffolds are used in maxillofacial surgery to reconstruct parts of maxillary bones, or other parts of the facial skeleton, or even in pre-prosthetic surgery, in order to increase the width of the alveolar ridges [6,7].…”

Section: Of 19mentioning

confidence: 99%

Dental Applications of Systems Based on Hydroxyapatite Nanoparticles—An Evidence-Based Update

et al. 2021

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Hydroxyapatite is one of the most studied biomaterials in the medical and dental field, because of its biocompatibility; it is the main constituent of the mineral part of teeth and bones. In dental science, hydroxyapatite nanoparticles (HAnps) or nano-hydroxyapatite (nano-HA) have been studied, over the last decade, in terms of oral implantology and bone reconstruction, as well in restorative and preventive dentistry. Hydroxyapatite nanoparticles have significant remineralizing effects on initial enamel lesions, and they have also been used as an additive material in order to improve existing and widely used dental materials, mainly in preventive fields, but also in restorative and regenerative fields. This paper investigates the role of HAnps in dentistry, including recent advances in the field of its use, as well as their advantages of using it as a component in other dental materials, whether experimental or commercially available. Based on the literature, HAnps have outstanding physical, chemical, mechanical and biological properties that make them suitable for multiple interventions, in different domains of dental science. Further well-designed randomized controlled trials should be conducted in order to confirm all the achievements revealed by the in vitro or in vivo studies published until now.

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Hydroxyapatite as a biomaterial – a gift that keeps on giving

Cited by 69 publications

References 285 publications

Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li₂O·11.10ZrO₂·69.32SiO₂ glass–ceramic

Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li₂O·11.10ZrO₂·69.32SiO₂ glass–ceramic

When Nothing Turns Itself Inside out and Becomes Something: Coating Poly(Lactic-Co-Glycolic Acid) Spheres with Hydroxyapatite Nanoparticles vs. the Other Way Around

Dental Applications of Systems Based on Hydroxyapatite Nanoparticles—An Evidence-Based Update

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Hydroxyapatite as a biomaterial – a gift that keeps on giving

Cited by 69 publications

References 285 publications

Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li2O·11.10ZrO2·69.32SiO2 glass–ceramic

Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li2O·11.10ZrO2·69.32SiO2 glass–ceramic

When Nothing Turns Itself Inside out and Becomes Something: Coating Poly(Lactic-Co-Glycolic Acid) Spheres with Hydroxyapatite Nanoparticles vs. the Other Way Around

Dental Applications of Systems Based on Hydroxyapatite Nanoparticles—An Evidence-Based Update

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Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li₂O·11.10ZrO₂·69.32SiO₂ glass–ceramic

Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li₂O·11.10ZrO₂·69.32SiO₂ glass–ceramic