Hydroxyapatite 3D-printed scaffolds with Gyroid-Triply periodic minimal surface (TPMS) porous structure: Fabrication and an in vivo pilot study in sheep

Bouakaz, Islam; Drouet, Christophe; Grossin, David; Cobraiville, Elisabeth; Nolens, Grégory

doi:10.1016/j.actbio.2023.08.041

Cited by 15 publications

(11 citation statements)

References 67 publications

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“…It can promote bone growth without causing toxicity, inflammation, or undesirable immune reactions [6,7]. HA bioceramic implants function as osteoinductive and osteoconductive scaffolds and therefore imitate the technical characteristics of human bone after osseointegration [16][17][18]25] (Table 2). Removal of the implant is therefore not required.…”

Section: Resultsmentioning

confidence: 99%

“…Removal of the implant is therefore not required. The macrostructure of HA implants is important for the osseointegration process and a high level of porosity (>50%) is essential [9,18,25,32]. Although multiple designs have been proposed, a gyroid macrostructure showed the fastest bone neoformation [2,18,25].…”

Section: Resultsmentioning

confidence: 99%

“…The macrostructure of HA implants is important for the osseointegration process and a high level of porosity (>50%) is essential [9,18,25,32]. Although multiple designs have been proposed, a gyroid macrostructure showed the fastest bone neoformation [2,18,25]. The highly curved pore corners of the gyroid design enhance bone regeneration and cellular attachment [18,20].…”

Section: Resultsmentioning

confidence: 99%

“…The highly curved pore corners of the gyroid design enhance bone regeneration and cellular attachment [18,20]. Because of this structure, these HA PSIs have a low compressive strength of 1-12 MPa, in the range of human cancellous bone [2,25,26] (Table 2). However, the strength of the material increases when osteogenesis is obtained [6,25].…”

Section: Resultsmentioning

confidence: 99%

“…Mechanical properties differ mainly in pore configuration, which is necessary to enhance bone ingrowth in the implant [24]. For example, the triply periodic minimal surface method (TPMS) has better strength than the conventional pore configuration [20,25]. TPMS was also applied in the PSIs designed for the clinical cases included in this review [22,23].…”

Section: Introductionmentioning

confidence: 99%

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Reconstruction of Craniomaxillofacial Bone Defects with 3D-Printed Bioceramic Implants: Scoping Review and Clinical Case Series

Verbist,

Vandevelde,

Geusens

et al. 2024

JCM

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Reconstruction of craniomaxillofacial bone defects using 3D-printed hydroxyapatite (HA) bioceramic patient-specific implants (PSIs) is a new technique with great potential. This study aimed to investigate the advantages, disadvantages, and clinical outcomes of these implants in craniomaxillofacial surgeries. The PubMed and Embase databases were searched for patients with craniomaxillofacial bone defects treated with bioceramic PSIs. Clinical outcomes such as biocompatibility, biomechanical properties, and aesthetics were evaluated and compared to those of commonly used titanium or poly-ether-ether-ketone (PEEK) implants and autologous bone grafts. Two clinical cases are presented to illustrate the surgical procedure and clinical outcomes of HA bioceramic PSIs. Literature review showed better a biocompatibility of HA PSIs than titanium and PEEK. The initial biomechanical properties were inferior to those of autologous bone grafts, PEEK, and titanium but improved when integrated. Satisfactory aesthetic results were found in our two clinical cases with good stability and absence of bone resorption or infection. Radiological signs of osteogenesis were observed in the two clinical cases six months postoperatively. HA bioceramic PSIs have excellent biocompatible properties and imitate natural bone biomechanically and radiologically. They are a well-suited alternative for conventional biomaterials in the reconstruction of load-sharing bone defects in the craniomaxillofacial region.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Reconstruction of Craniomaxillofacial Bone Defects with 3D-Printed Bioceramic Implants: Scoping Review and Clinical Case Series

Verbist,

Vandevelde,

Geusens

et al. 2024

JCM

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Molecularly Imprinted Macroporous Hydrogel Promotes Bone Regeneration via Osteogenic Induction and Osteoclastic Inhibition

Chen,

Jing,

Liu

et al. 2024

Adv Healthcare Materials

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Macroporous hydrogels offer physical supportive spaces and bio‐instructive environment for the seeded cells, where cell‐scaffold interactions directly influence cell fates and subsequently affect tissue regeneration post‐implantation. Effectively modifying bioactive motifs at the inner pore surface provides appropriate niches for cell‐scaffold interactions. A molecular imprinting method and sacrificial templates are introduced to prepare inner pore surface modification in the macroporous hydrogels. In detail, acrylated bisphosphonates (Ac‐BPs) chelating to templates (CaCO3 particles) are anchored on the inner pore surface of the methacrylated gelatin‐methacrylated hyaluronic acid‐poly (ethylene glycol) diacrylate (GHP) macroporous hydrogel to form a functional hydrogel scaffold (GHP‐int‐BP). GHP‐int‐BP, but not GHP, effectively crafts artificial cell niches to substantially alter cell fates, including osteogenic induction and osteoclastic inhibition, and promote in‐situ bone regeneration. These findings highlight that molecular imprinting on the inner pore surface in the hydrogel efficiently creates orthogonally additive bio‐instructive scaffolds for bone regeneration.This article is protected by copyright. All rights reserved

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Three‐Dimensionally Printed Biphasic Calcium Phosphate Ceramic Substrates as the Sole Inducer of Osteogenic Differentiation in Stromal Vascular Fraction Cells

Brochet,

Thomann,

Chocarro‐Wrona

et al. 2024

J Biomed Mater Res

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The stromal vascular fraction (SVF) is a derivate of fat tissue comprising both adipose‐derived mesenchymal stem cells and endothelial cells and serves as a promising cell source for engineering vascularized bone tissues. Its combination with osteoconductive biphasic calcium phosphate (BCP) ceramic may represent a point‐of‐care agent for bone reconstruction. Here we assessed the proliferation and osteogenic differentiation capacities of SVF on 3D printed BCP implants, in comparison with isolated adipose‐derived mesenchymal stem cells (AD‐MSCs). AD‐MSCs and SVF isolated from human donors were seeded on plastic or 3D printed BCP ceramics with sinusoidal or gyroid macrotopography and cultured in the presence or absence of osteogenic factors. Vascular, hematopoietic and MSC surface markers were assessed by flow cytometry whereas osteogenic activity was investigated through alizarin red staining and alkaline phosphatase activity. Osteogenic factors were necessary to trigger osteogenic activity when cells were cultured on plastic, without significant difference observed between the two cell populations. Interestingly, osteogenic activity was observed on BCP implants in the absence of differentiation factors, without significant difference in level activity between the two cell populations and macrotopography. This study offers supportive data for the use of combined BCP scaffolds with SVF in a perspective of a one‐step surgical procedure for bone regeneration.

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Hydroxyapatite 3D-printed scaffolds with Gyroid-Triply periodic minimal surface (TPMS) porous structure: Fabrication and an in vivo pilot study in sheep

Cited by 15 publications

References 67 publications

Reconstruction of Craniomaxillofacial Bone Defects with 3D-Printed Bioceramic Implants: Scoping Review and Clinical Case Series

Reconstruction of Craniomaxillofacial Bone Defects with 3D-Printed Bioceramic Implants: Scoping Review and Clinical Case Series

Molecularly Imprinted Macroporous Hydrogel Promotes Bone Regeneration via Osteogenic Induction and Osteoclastic Inhibition

Three‐Dimensionally Printed Biphasic Calcium Phosphate Ceramic Substrates as the Sole Inducer of Osteogenic Differentiation in Stromal Vascular Fraction Cells

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