Hydroxy-α-sanshool isolated from <i>Zanthoxylum bungeanum</i> attenuates learning and memory impairments in scopolamine-treated mice

Zhang, Mengmeng; Xie, Mingguo; Wei, Daneng; Wang, Li; Hu, Mei-Bian; Zhang, Qing; He, Zuxin; Peng, Wei

doi:10.1039/c9fo00045c

Cited by 34 publications

(16 citation statements)

References 36 publications

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“…In addition, the unsaturated fatty acid amides in Z. bungeanum pericarps, such as hydroxy- α -sanshool (HAS), hydroxy- β -sanshool, and hydroxy- γ -sanshool, also have wide-spectrum pharmacological activities, including hypolipidemic and hypoglycemic effects and anti-inflammatory and neurotrophic effects [ 17 , 18 ]. Further studies have also shown that HAS has an antioxidant effect and can improve scopolamine-induced learning and memory impairments in rats [ 19 , 20 ]. Consequently, we speculated that HAS may have neuroprotective potentials, and the present study was aimed at investigating the protective effect of HAS and its related possible mechanisms using a H 2 O 2 -stimulated PC12 cell model.…”

Section: Introductionmentioning

confidence: 99%

Hydroxy-α-sanshool Possesses Protective Potentials on H₂O₂-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Zhang

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

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Zanthoxylum bungeanum pericarp is a commonly used herbal medicine in China with effects of anti-inflammatory and analgesic, improving learning and memory ability, while hydroxy-α-sanshool (HAS) is the most important active ingredient of Z. bungeanum pericarps. The purpose of this study was to investigate the neuroprotective effect of HAS and its related possible mechanisms using a H2O2-stimulated PC12 cell model. CCK-8 assay results showed that HAS had a significant protective effect on H2O2-stimulated PC12 cells without obvious cytotoxicity on normal PC12 cells. Flow cytometry and fluorescence microscope (DAPI staining and DCFH-DA staining) indicated that HAS could reduce the H2O2-induced apoptosis in PC12 cells via reduction of intracellular ROS and increase of mitochondrial membrane potential (MMP). Subsequently, results of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) determination suggested that HAS could increase the enzyme activities of SOD, CAT, and GSH-Px whereas it could decrease the MDA contents in H2O2-stimulated PC12 cells. Furthermore, the western blotting assays showed that HAS could upregulate the expressions of p-PI3k, Akt, p-Akt, and Bcl-2, while it could downregulate the expressions of cleaved caspase-3 and Bax in H2O2-stimulated PC12 cells. Collectively, it could be concluded according to our results that HAS possesses protective potentials on H2O2-stimulated PC12 cells through suppression of oxidative stress-induced apoptosis via regulation of PI3K/Akt signal pathway.

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Section: Introductionmentioning

confidence: 99%

Hydroxy-α-sanshool Possesses Protective Potentials on H₂O₂-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Zhang

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…The plants of ZA are mainly distributed in southern China [4,7], and ZA pericarps are popular in Sichuan cuisine, especially in hotpot. The pericarps of ZA and ZB are commonly used as spices for their special flavor and are a therapeutically efficacious traditional medicine [11,12]. The therapeutic efficacy of the two popular species is mainly because of the presence of volatile…”

Section: Introductionmentioning

confidence: 99%

Volatile Oil Profile of Prickly Ash (Zanthoxylum) Pericarps from Different Locations in China

Tian

Chen

et al. 2021

Foods

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Volatile oils of prickly ash (Zanthoxylum) pericarps have various potential biological functions with considerable relevance to food, pharmacological, and industrial applications. The volatile profile of oils extracted from prickly ash pericarps obtained from 72 plantations in China was determined by gas chromatography and mass spectrometry. Several chemometric analyses were used to better understand the volatile oil profile differences among different pericarps and to determine the key factors that affected geographical variations in the main volatile constituents of oils. A total of 47 constituents were detected with D-limonene, alfa-myrcene, and linalool as the most abundant. The volatile profile of pericarp oils was significantly affected by prickly ash species and some environmental factors, and the key factors that affected volatile profile variations for different prickly ash species were diverse. Chemometric analyses based on the volatile oil profile could properly distinguish Z. armatum pericarps from other pericarps. This study provides comprehensive information on the volatile oil profile of pericarps from different prickly ash species and different plantations, and it can be beneficial to a system for evaluating of pericarp quality. Moreover, this study speculates on the key environmental factors that cause volatile oil variations for each species, and can help to obtain better prickly ash pericarp volatile oils by improving the cultivated environments.

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“…Recent studies have demonstrated that active substances in plants can be used to potentially establish novel therapies for AD [7]. Compounds isolated from plants, such as flavonoids and other polyphenols in medicinal plants, might prevent neurodegeneration and enhance memory and cognitive function [8]. Thus, products from certain plants are a major source for new drug discovery.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Processed Polygoni multiflori Radix and Its Major Substance during Scopolamine-Induced Cognitive Dysfunction

Kim

et al. 2021

Processes

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Alzheimer’s disease (AD) is the most common cognitive disorder in the elderly population. However, effective pharmacological agents targeting AD have not been developed. The processed Polygoni multiflori Radix (PPM) and its main active substance, 2,3,5,4′-tetrahydroxystilbene-2-O-β-glucoside (TSG), has received considerable attention, majorly due to its neuroprotective activities against multiple biological activities within the human body. In this study, we provide new evidence on the therapeutic effect of PPM and TSG during cognitive impairment by evaluating the ameliorative potential of PPM and TSG in scopolamine-induced amnesia in ICR mice. PPM (100 or 200 mg/kg) was orally administered during the experimental period (days 1–15), and scopolamine was intraperitoneally injected to induce cognitive deficits during the behavioural test periods (days 8–15). The administration of PPM and TSG significantly improved memory loss and cognitive dysfunction in behavioural tests and regulated the cholinergic function, brain-derived neurotrophic factor, and neural apoptosis. The present study suggests that PPM and TSG improved scopolamine-induced cognitive dysfunction, but further study has to be supported for the clinical application of PPM and TSG for AD prevention and treatment.

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Hydroxy-α-sanshool isolated from Zanthoxylum bungeanum attenuates learning and memory impairments in scopolamine-treated mice

Abstract: Learning and memory impairments are common symptoms of dementia in neurodegenerative disorders.

Cited by 34 publications

References 36 publications

Hydroxy-α-sanshool Possesses Protective Potentials on H₂O₂-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Hydroxy-α-sanshool Possesses Protective Potentials on H₂O₂-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Volatile Oil Profile of Prickly Ash (Zanthoxylum) Pericarps from Different Locations in China

Protective Effect of Processed Polygoni multiflori Radix and Its Major Substance during Scopolamine-Induced Cognitive Dysfunction

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Hydroxy-α-sanshool isolated from Zanthoxylum bungeanum attenuates learning and memory impairments in scopolamine-treated mice

Abstract: Learning and memory impairments are common symptoms of dementia in neurodegenerative disorders.

Cited by 34 publications

References 36 publications

Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Volatile Oil Profile of Prickly Ash (Zanthoxylum) Pericarps from Different Locations in China

Protective Effect of Processed Polygoni multiflori Radix and Its Major Substance during Scopolamine-Induced Cognitive Dysfunction

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Hydroxy-α-sanshool Possesses Protective Potentials on H₂O₂-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Hydroxy-α-sanshool Possesses Protective Potentials on H₂O₂-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway