Hydroxy- and aminomethylation of 1-methyl-2-amino-4-imidazolinone

Рамш, С. М.; Zheltonog, N. G.; Храброва, Е. С.; Golovanova, E. A.

doi:10.1007/bf00472506

Cited by 5 publications

(2 citation statements)

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“…Paulmann further clarified that creatinine was an internal anhydride of methylguanido acetic acid (Paulmann, 1894). Its hydration form creatine is involved in regulatory mechanisms of higher organisms (Ramsh et al, 1991). Being biocompatible and biodegradable, creatinine and its derivatives have been extensively investigated for biomedical applications like vasodilatative, hypoglycaemic, bacteriostatic (Lempert, 1959) analgesic (Khan et al, 2015) and anticonvulsant effects (Cade, 1947;Pfeifer et al, 1952).…”

Section: Introductionmentioning

confidence: 98%

Development of a biocompatible creatinine-based niosomal delivery system for enhanced oral bioavailability of clarithromycin

et al. 2016

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Section: Introductionmentioning

confidence: 98%

Development of a biocompatible creatinine-based niosomal delivery system for enhanced oral bioavailability of clarithromycin

et al. 2016

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“…[ 16 ] Its hydration form, creatine, is involved in regulatory mechanisms of higher organisms. [ 20,21 ] Being biocompatible and biodegradable, CR and its derivatives have been extensively investigated in biomedical applications like vasodilatative, hypoglycemic, bacteriostatic, analgesic, and anticonvulsant effects. [ 22–25 ] It has also been studied in biochemical and functional studies.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structure, Hirshfeld surface, DFT, and molecular docking studies of a new organic cocrystal: creatinine:2,3‐pyridinedicarboxylic acid

Matheswari

Asha

Bhuvanesh

et al. 2021

J of Physical Organic Chem

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A new cocrystal (CR:2,3PDCA) of creatinine (CR) with 2,3‐pyridine dicarboxylic acid (2,3PDCA) was grown by slow evaporation method, and its crystal structure was characterized by single‐crystal X‐ray diffraction (SCXRD) analysis. The cocrystal was found to be triclinic with space group P‐1 and lattice parameters a = 7.3610(7) Å, b = 8.7813(9) Å, and C = 9.4173(10) Å. The intermolecular hydrogen bonds, namely, N‐H…N and C‐O…H‐N interactions, together play a major role in stabilizing the cocrystal. Further, the molecular interactions in the crystal structure were analyzed by considering short contacts and intermolecular contactsusing Hirshfeld surface methods. Furthermore, the coordinates of cocrystal were obtained by DFT calculations using the B3LYP method with a 6‐311++G (d,p) basis set. Besides this, other molecular properties such as frontier molecular orbital, HOMO‐LUMO energies, and Mulliken charge analysis were also reported. Furthermore, a molecular docking study was performed to study the anti‐inflammatory property of the cocrystal using the Auto‐Dock vina program by investigating the binding patterns of the synthesized cocrystal into a 1R35 inhibitor. In vitro anti‐microbial activities against some bacterial and fungal strains were also investigated.

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Imidazoles

Grimmett

1996

Comprehensive Heterocyclic Chemistry II

109

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Hydroxy- and aminomethylation of 1-methyl-2-amino-4-imidazolinone

Cited by 5 publications

References 3 publications

Development of a biocompatible creatinine-based niosomal delivery system for enhanced oral bioavailability of clarithromycin

Development of a biocompatible creatinine-based niosomal delivery system for enhanced oral bioavailability of clarithromycin

Synthesis, structure, Hirshfeld surface, DFT, and molecular docking studies of a new organic cocrystal: creatinine:2,3‐pyridinedicarboxylic acid

Imidazoles

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