Hydroxamic Acids as Pharmacological Agents

Abstract

A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A(4) hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.

Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents

“…Matrilysin belongs to the matrix metalloproteinase (MMP) family of zinc-containing enzymes related to PDF (44). PDF-611 (LBK-611) and PDF-709 inhibited H. sapiens PDF with IC 50 s of 115 nM and 147 nM, respectively (Table 2).…”

[(η6-p-cymene)Ru(H2O)3]2+ binding capability of aminohydroxamates — A solution and solid state study

“…[1][2][3] Hydroxamates are also considered as effective inhibitors of various metalloenzymes. [3][4] Both type of biological activity is obviously connected to their capability of forming stable five-membered [O,O] chelate(s) with various, mostly hard type metal ions.…”

Studies on Some Salicylhydroxamate Complexes of Aryltellurium(IV)

“…Hence they are involved in many biochemical processes such as iron transport phenomena 1 , inhibition of enzymatic activity of urease 2,3 , Alzheimer's Amyloid precursor protein α-secretase 4 and some matrix metalloproteinases 5 . They also display antibacterial, anti inflammatory and anti-asthmatic behaviour 6,7 and have been utilized in the design of therapeutic targets for cancer 8,9 , Alzheimer's disease 10 , haemochromatosis 11,12 and malaria 13 . Hydroxamic acids have been extensively studied as bioligands forming chelate complexes with numerous metals [14][15][16][17] including organotin complexes 18,19 .…”