Hydrotropic Solubilization in Pharmaceutical Analysis: Origin, Evolution, Cumulative Trend and Precise Applications

Patil, Mangesh R.; Ganorkar, Saurabh B.; Patil, Amod S.; Shirkhedkar, Atul A.; Surana, Sanjay J.

doi:10.1080/10408347.2020.1718484

Cited by 14 publications

(5 citation statements)

References 35 publications

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“…Most of the research documented single, zeroth-order UV measurement during the development and validation of the methods. Evaluations of procedures used in UV spectrometry show that several types of research include zeroth-order UV methods …”

Section: Applicationmentioning

confidence: 99%

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Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

2021

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Drug molecules’ therapeutic efficacy depends on their bioavailability and solubility. But more than 70% of the formulated drug molecules show limited effectiveness due to low water solubility. Thus, the water solubility enhancement technique of drug molecules becomes the need of time. One such way is hydrotropy. The solubilizing agent of a hydrophobic molecule is generally referred to as a hydrotrope, and this phenomenon is termed hydrotropy. This method has high industrial demand, as hydrotropes are noninflammable, readily available, environmentally friendly, quickly recovered, cost-effective, and not involved in solid emulsification. The endless importance of hydrotropes in industry (especially in the pharmaceutical industry) motivated us to prepare a feature article with a clear introduction, detailed mechanistic insights into the hydrotropic solubilization of drug molecules, applications in pharma industries, and some future directions of this technique. Thus, we believe that this feature article will become an adequate manual for the pharmaceutical researchers who want to explore all of the past perspectives of the hydrotropic action of hydrotropes in pharmaceutics.

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Section: Applicationmentioning

confidence: 99%

“…Evaluations of procedures used in UV spectrometry show that several types of research include zeroth-order UV methods. 100 Hydrotrope as a Drug Carrier. One of the critical challenges in the nanodrug delivery system (NDDS) is the poor encapsulation of drug molecules.…”

Section: ■ Mechanistic Insightmentioning

confidence: 99%

Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

2021

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“…Stress studies are an essential part of the high‐performance liquid‐chromatography (HPLC) methods (Ganorkar et al, 2020) as checks on changes in the chemical properties of the drug over time and in various situations (Patil et al, 2021a, 2021b). Such studies also influence the specificity of the HPLC method (George, 2010).…”

Section: Introductionmentioning

confidence: 99%

HPLC–PDA identification and resolution of rufinamide forced degradation impurities: A congregated chemometric expedite optimization coupled with factorials and desirability

Ganorkar

Chaudhari

Bobade

et al. 2022

Biomedical Chromatography

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Rufinamide is used presently to treat Lenaux-Gastaut syndrome. A full factorial design and desirability approach was investigated for the optimization of hydrolytic stress via response surface curves (RSCs). The degradation impurities were identified and resolved using reversed-phase high-performance liquid chromatography (RP-HPLC) on the Qualisil ® BDS C 8 column. Acetonitrile-water (29:71, v/v) was optimized for the mobile phase and used at a flow rate of 1.0 ml/min with detection at a wavelength of 230 nm. Rufinamide showed appreciable susceptibility to hydrolysis under acidic and alkaline stress, and substantial degradation in the neutral condition.It degraded much less under oxidative stress. Exposure towards thermal and photolytic stress conditions indicated appreciable stability. The developed method was subjected to validation as per the recommendations of the International Conference on Harmonization. The proposed method showed no influence from the excipients and the degradation products. As well as good precision and accuracy in determination, the method showed a linear response between 2 and 12 μg ml À1 . The method was extended for determination in a human plasma sample, which resulted in excellent recovery without interference from matrix effects. The combined use of desirability and design for the optimization of acidic and alkaline hydrolytic stress led to simple and rapid analysis.

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“…Hydrotropes are a class of water-soluble compounds capable of greatly increasing the aqueous solubility of hydrophobic solutes, including drugs [17][18][19][20][21][22]. Besides drug solubilization, hydrotropy is also used in detergent formulation, health care and household applications, and extraction of bioactive compounds [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Cholinium-based ionic liquids as bioinspired hydrotropes to tackle solubility challenges in drug formulation

Sintra

Abranches

Benfica

et al. 2021

European Journal of Pharmaceutics and Biopharmaceutics

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Hydrotropic Solubilization in Pharmaceutical Analysis: Origin, Evolution, Cumulative Trend and Precise Applications

Cited by 14 publications

References 35 publications

Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

HPLC–PDA identification and resolution of rufinamide forced degradation impurities: A congregated chemometric expedite optimization coupled with factorials and desirability

Cholinium-based ionic liquids as bioinspired hydrotropes to tackle solubility challenges in drug formulation

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