“…15,16 Solution properties, such as pH, viscosity, specific gravity, surface tension, refractive index, conductance, and diffusion rate, were thoroughly examined. 10,17 These studies led to proposals of several potential mechanisms, including complexation, ''salting-in,'' changes in the nature of the solvent, 2,8 and molecular aggregation. 17,18 Nevertheless, for most hydrotropic systems the solubilization mechanisms remain a topic of debate, 7 which is exemplified in the case of nicotinamide (NA) below.…”