Hydrothermal vs microwave nanoarchitechtonics of carbon dots significantly affects the structure, physicochemical properties, and anti-cancer activity against a specific neuroblastoma cell line

Seven, Elif S.; Cilingir, Emel Kirbas; Bartoli, Mattia; Zhou, Yiqun; Sampson, Rachel; Shi, Wenquan; Peng, Zhili; Pandey, Raja R.; Chusuei, Charles C.; Tagliaffero, Alberto; Vanni, Steven; Graham, Regina M.; Seven, Yasin B.; Leblanc, Roger M.

doi:10.1016/j.jcis.2022.10.010

Cited by 16 publications

(17 citation statements)

References 44 publications

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“…PCDs’ chemistry is also deeply affected by their synthesis conditions, as reported by Seven et al [ 136 ]. The authors investigated the formation of PCDs using glucose as a single precursor under microwave irradiation or through hydrothermal conditions showing two possible pathways, as reported in Figure 8 .…”

Section: Cds’ Optical and Chemical Characteristicsmentioning

confidence: 88%

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An Overview on Carbon Quantum Dots Optical and Chemical Features

et al. 2023

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Carbon quantum dots are the materials of a new era with astonishing properties such as high photoluminescence, chemical tuneability and high biocompatibility. Since their discovery, carbon quantum dots have been described as nanometric high-fluorescent carbon nanoparticles, but this definition has become weaker year after year. Nowadays, the classification and the physical explanation of carbon quantum dots optical properties and their chemical structure remain matter of debate. In this review, we provide a clear discussion on these points, providing a starting point for the rationalization of their classification and a comprehensive view on the optical and chemical features of carbon quantum dots.

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Section: Cds’ Optical and Chemical Characteristicsmentioning

confidence: 88%

“… Schematic chemical pathway for the production of GQDs or PCDs using glucose as precursors and different synthetic routes. Reprinted with permission from Seven et al [ 136 ]. …”

Section: Figurementioning

confidence: 99%

An Overview on Carbon Quantum Dots Optical and Chemical Features

et al. 2023

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“…Similarly, the concentration of DFMO-CDs required to inhibit 50 percent of SMS-KCNR cell lines was over 30 times lower than that of conventional DFMO required to inhibit the same quantity of cell lines and superseded conjugated DFMO on non-toxic black carbon dots (BCD-DFMO) 113 . However, the latest research that falls under the focus of this review reports an astonishing observation 114 . Here, CDs were synthesized by two synthetic approaches (Figure 2 ) : hydrothermal and microwave.…”

Section: Cytotoxic Carbon Dots From Pure Organic Compoundsmentioning

confidence: 98%

“…CDs prepared by hydrothermal at the temperature of 200ºC and 160ºC for 5 hours showed particular anti-cancer activity against SMS-KCNR while non-toxic towards SK-N-AS and normal cell lines, HEK-293 and human mesenchymal stem cells (MSC). The anti-cancer activity was linked to the synthesis method because similar CDs prepared from microwave synthesis showed no observable toxicity towards both cancer and healthy cell lines 114 . Overall, it could be observed that a few things are now more obvious.…”

Section: Cytotoxic Carbon Dots From Pure Organic Compoundsmentioning

confidence: 99%

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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Fluorescent Carbon dots (CDs) derived from biologically active sources have shown enhanced activities compared to their precursors. With their prominent potentiality, these small-sized (<10nm) nanomaterials could be easily synthesized from organic sources either by bottom-up or green approach. Their sources could influence the functional groups present on the CDs surfaces. A crude source of organic molecules has been used to develop fluorescent CDs. In addition, pure organic molecules were also valuable in developing practical CDs. Physiologically responsive interaction of CDs with various cellular receptors is possible due to the robust functionalization on their surface. In this review, we studied various literatures from the past ten years that reported the potential application of carbon dots as alternatives in cancer chemotherapy. The selective cytotoxic nature of some of the CDs towards cancer cell lines suggests the role of surface functional groups towards selective interaction, which results in over-expressed proteins characteristic of cancer cell lines. It could be inferred that cheaply sourced CDs could selectively bind to overexpressed proteins in cancer cells with the ultimate effect of cell death induced by apoptosis. In most cases, CDs-induced apoptosis directly or indirectly follows the mitochondrial pathway. Therefore, these nanosized CDs could serve as alternatives to the current kinds of cancer treatments that are expensive and have numerous side effects.

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“…CQDs synthesized using this technique have been found to show better biocompatibility than the ones prepared by the popularly used solvothermal method. 32 Although this method can exhibit poor control over size, it executes homogeneous distribution of energy into the sample via dielectric heating which makes nanoparticles highly reproducible, whereas in an oil bath or heating mantle the reaction vessel is heated first. 33 In waste-derived technique, CQDs synthesized from natural biomass are explored for designing green material-based composite films for light conversion at glass windows for the houses in low-carbon cities.…”

Section: Introductionmentioning

confidence: 99%