Hydrothermal Synthesize of HF-Free MIL-100(Fe) for Isoniazid-Drug Delivery

Abstract

Sustainable development of drug delivery materials with good biocompatibility and controlled-release is a popular topic among researchers. In this research study, we demonstrated the potential of the metal-organic framework, that is MIL-100(Fe), as a drug delivery platform for isoniazid (INH). The MIL-100(Fe) was prepared by using the hydrofluoric acid-free hydrothermal method. Several physical measurements were conducted to characterize the MIL-100(Fe), including x-ray diffraction (XRD), scanning electron microscopy (SEM), nitrogen sorption, and thermal-gravimetric (TG). The synthesized MIL-100(Fe) has octahedron-shaped particles with superior properties, that is large surface area (1456.10 m2/g) and pore volume (1.25 cm3/g). The drug loading rate and capacity were determined by means of adsorption kinetic and isotherm. The studied INH@MIL-100(Fe) adsorption system kinetics follow the pseudo-first-order model, while the isotherm system follows the Langmuir model with the maximum adsorption capacity of 128.5 mg/g at 30 °C. MIL-100(Fe) shows adequate biocompatibility, also exhibits a reasonable and controlled drug release kinetics. The results obtained show that MIL-100 (Fe) can be a good choice of drug delivery platform among other available platforms.

Recent advances in process engineering and upcoming applications of metal–organic frameworks

“…Another factor in producibility is reaction temperature. The usual MOF synthesis involves heating of the reaction medium, and in many cases, the temperature must exceed the boiling points of the solvents [29] , [30] , [31] . Usually, water-based reactions are heated to above 100 °C and require a high-pressure reactor, called a “digestion bomb.” This approach is inadequate for large-scale production because it requires costly, large-scale, pressure-proof reactors, which decreases the producibility.…”

Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework

“…The MIL-100(Fe) and Fe-BTC structures consist of similar building blocks with the former material being crystalline [ 54 , 55 ]. The secondary building blocks (SBU) are Fe(III)( μ 3 -O) trimers that are linked by BTC forming a super tetrahedron structure.…”

Influence of carbohydrate polymer shaping on organic dye adsorption by a metal–organic framework in water

“…Because it meets these prerequisites, the MOF, MIL-100(Fe) (denoted as MIL), constructed from trivalent Fe 3+ cations and 1,3,5-benzenetricarboxylic acid ligands (Fig. 1), 17,18 has been utilized as a potential adsorbent for removing organic and inorganic pollutants in aqueous solution. 12,[19][20][21][22][23] Fe is a very abundant less toxic metal, and 1,3,5-benzenetricarboxylic acid is commercially available and has been used for the synthesis of a variety of MOFs.…”

“…12,[19][20][21][22][23] Fe is a very abundant less toxic metal, and 1,3,5-benzenetricarboxylic acid is commercially available and has been used for the synthesis of a variety of MOFs. 17,18,24,25 Moreover, MIL is highly stable in water because it contains a strong Fe 3+ trivalent cation-COO À monoanion coordination bond. Furthermore, it was recently reported that this MOF can be synthesized in aqueous solution without using additives.…”