Hydrothermal synthesis of hydroxyapatite nanoparticles and their protein adsorption behavior

Nagata, Fukue; Yamauchi, Yasuki; Tomita, Masahiro; Kato, Katsuya

doi:10.2109/jcersj2.121.797

Cited by 20 publications

(5 citation statements)

References 29 publications

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“…Several synthetic strategies have been employed for fabricating nHA including wet chemical precipitation, hydrothermal method, microwave irradiation, sol gel, emulsion, etc. The morphology, crystallite size, stoichiometry and chemical composition of nHA prepared from these routes differ substantially from one to another [86,87,88,89,90,91,92,93,94]. Among these, wet chemical precipitation is one of the most commonly technique used for forming nHA due to its simplicity, and ease of fabrication without using organic solvents.…”

Section: Preparation Of Nanofillersmentioning

confidence: 99%

“…below 350 °C) and pressures in aqueous solutions enables the formation of nHA crystals with homogeneous chemical compositions [87,90,91]. Nagata et al prepared nHA rods from Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 precursors by treating the solutions hydrothermally at 60 °C, 120 °C and 180 °C under a pH of 10 [90]. Xue et al also obtained HA nanorods by means of hydrothermal route [91].…”

Section: Preparation Of Nanofillersmentioning

confidence: 99%

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Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications

Liao

Tjong

2019

Nanomaterials

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This paper provides review updates on the current development of bionanocomposites with polymeric matrices consisting of synthetic biodegradable aliphatic polyesters reinforced with nanohydroxyaptite (nHA) and/or graphene oxide (GO) nanofillers for bone tissue engineering applications. Biodegradable aliphatic polyesters include poly(lactic acid) (PLA), polycaprolactone (PCL) and copolymers of PLA-PGA (PLGA). Those bionanocomposites have been explored for making 3D porous scaffolds for the repair of bone defects since nHA and GO enhance their bioactivity and biocompatibility by promoting biomineralization, bone cell adhesion, proliferation and differentiation, thus facilitating new bone tissue formation upon implantation. The incorporation of nHA or GO into aliphatic polyester scaffolds also improves their mechanical strength greatly, especially hybrid GO/nHA nanofilllers. Those mechanically strong nanocomposite scaffolds can support and promote cell attachment for tissue growth. Porous scaffolds fabricated from conventional porogen leaching, and thermally induced phase separation have many drawbacks inducing the use of organic solvents, poor control of pore shape and pore interconnectivity, while electrospinning mats exhibit small pores that limit cell infiltration and tissue ingrowth. Recent advancement of 3D additive manufacturing allows the production of aliphatic polyester nanocomposite scaffolds with precisely controlled pore geometries and large pores for the cell attachment, growth, and differentiation in vitro, and the new bone formation in vivo.

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Section: Preparation Of Nanofillersmentioning

confidence: 99%

Section: Preparation Of Nanofillersmentioning

confidence: 99%

Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications

Liao

Tjong

2019

Nanomaterials

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“…The research paper [ 32 ] studied the effect of temperature on the degree of crystallinity. With increased hydrothermal process temperature, the degree of crystallinity was found to increase.…”

Section: Resultsmentioning

confidence: 99%

Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM)

2021

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Hydroxyapatite (HAp)—[Ca10 (PO4)6(OH) 2] has a similar chemical composition to bone material, making it the main mineral supplement in bone-making. Due to its high biocompatibility, hydroxyapatite is widely used in the repair of bone deficiencies and in the production of dental or orthopedic implants. In this research, hydroxyapatite nanopowder was synthesized using a hydrothermal technique. Fourier Transform Infrared Spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to investigate the chemical structure and morphology of the synthesized hydroxyapatite powder. X-ray diffraction (XRD) was used to evaluate the phase analysis of HAp nanopowder. In addition, bioactivity HAp assessment was conducted by scanning electron microscopy (SEM) attached with Energy Dispersive X-Ray Spectroscopy (EDX) analysis. Response Surface Methodology (RSM) with central composite design (CCD) was used in order to determine the optimal conditions for yield, size, and crystallinity. Three independent variables (pH, temperature, and hydrothermal treatment time) were investigated. The yield was observed to increase in alkaline conditions; pH showed the greatest influence on the yield, size, and crystallinity of the synthesized hydroxyapatite, based on Analysis of Variance. The results of bioactivity evaluation are showed high bioactivity due to the formation of apatite on the surface of the synthesized nanopowder.

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“…Table 4 also shows that, for a fixed HAp/BG ratio, the degree of crystallinity and the intensity of peaks in the HAp phase increased with hydrothermal process temperature. In a study by [39], increased hydrothermal process temperature was found to increase the degree of crystallinity in HAp [39].…”

Section: Xrd Analysismentioning

confidence: 97%

Synthesis of Hydroxyapatite/Bioglass Composite Nanopowder Using Design of Experiments

Ebrahimi

Sipaut

2022

Nanomaterials

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Composite scaffolds of hydroxyapatite (HAp) nanoparticles and bioactive glass (BG) were applied as an appropriate selection for bone tissue engineering. To this end, HAp/BG composite was synthesized by a hydrothermal method using Design of Experiments (DOE) with a combined mixture–process factor design for the first time. The input variables were hydrothermal temperature at three levels (i.e., 100, 140, 180 °C) as a process factor and two mixture components in three ratios (i.e., HAp 90, 70, 50; BG 50, 30, 10). The degree of crystallinity and crystal size in the composite were the output variables. XRD showed that only a small fraction of BG was crystallized and that a wollastonite phase was produced. The XRD results also revealed that incorporation of Si into the HAp structure inhibited HAp crystal growth and restricted its crystallization. The FTIR results also showed that the intensity of the hydroxyl peak decreased with the addition of silicon into the HAp structure. DOE results showed that the weight ratio of the components strongly influenced the crystal size and crystallinity. SEM and FTIR results identified the greatest bioactivity and apatite layer formation in the Si-HAp sample with an HAp70/BG30 ratio after 14 days immersion in simulated body fluid (SBF) solution, as compared to other ratios and HAp alone. Therefore, the combination of HAp and BG was able to yield a HAp/BG composite with significant bioactivity.

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Hydrothermal synthesis of hydroxyapatite nanoparticles and their protein adsorption behavior

Cited by 20 publications

References 29 publications

Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications

Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications

Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM)

Synthesis of Hydroxyapatite/Bioglass Composite Nanopowder Using Design of Experiments

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