“…4,5 Therefore, the synthesis of particles with optimized size, morphology, crystallinity, stoichiometry and phase composition has become a focus of interest in the biomedical fields. [2][3][4][5][6] In the literature, several methods for preparing HAp nanoparticles have been reported, including chemical precipitation, 11,12 solid-state synthesis, 13,14 sol-gel process, 11,15,16 solvo-treatment process, 17 hydrothermal method, 10,[17][18][19][20][21] biomimetic synthesis, 22,23 spray pyrolysis 24,25 and solvothermal procedure. [26][27][28] Moreover, many of such studies have been made to improve the mechanical properties, using one-dimensional growth of HAp crystals and preparing needle-like or rod-like particles.…”