Hydrothermal synthesis of hydroxyapatite

Earl, J.S.; Wood, David; Milne, Steven J.

doi:10.1088/1742-6596/26/1/064

Cited by 123 publications

(101 citation statements)

References 8 publications

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Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10] However, the low mechanical properties of HAp nanoparticles have limited their use in load-bearing orthopedic and dental applications. 4,5 Therefore, the synthesis of particles with optimized size, morphology, crystallinity, stoichiometry and phase composition has become a focus of interest in the biomedical fields. [2][3][4][5][6] In the literature, several methods for preparing HAp nanoparticles have been reported, including chemical precipitation, 11,12 solid-state synthesis, 13,14 sol-gel process, 11,15,16 solvo-treatment process, 17 hydrothermal method, 10,[17][18][19][20][21] biomimetic synthesis, 22,23 spray pyrolysis 24,25 and solvothermal procedure.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Therefore, the synthesis of particles with optimized size, morphology, crystallinity, stoichiometry and phase composition has become a focus of interest in the biomedical fields. [2][3][4][5][6] In the literature, several methods for preparing HAp nanoparticles have been reported, including chemical precipitation, 11,12 solid-state synthesis, 13,14 sol-gel process, 11,15,16 solvo-treatment process, 17 hydrothermal method, 10,[17][18][19][20][21] biomimetic synthesis, 22,23 spray pyrolysis 24,25 and solvothermal procedure. [26][27][28] Moreover, many of such studies have been made to improve the mechanical properties, using one-dimensional growth of HAp crystals and preparing needle-like or rod-like particles.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20][21][26][27][28][29] It is known that HAp nanorods can be synthesized; however, the preparation of nano-sized particles with high aspect ratio, appropriate stoichiometry and high crystallinity still remains an important task. 4,5,[19][20][21][25][26][27][28][29][30][31][32] The hydrothermal method, which works at high temperature and high pressure, is the most frequently used technique for one-dimensional growth of HAp. This method enables the synthesis of HAp powders with high degree of crystallinity which are relatively stable in physiological medium.…”

Section: Introductionmentioning

confidence: 99%

“…4,10,[17][18][19][20][21][22][23][24][25][26][27]34 However, many different studies have resulted in discrepancies in the optimum experimental conditions. For instance, some works show that the rod-like HAp is synthesized in acidic 5,35 or approximately neutral conditions, 28 and others show that these nanorods are synthesized under alkaline conditions. [30][31][32]36 Moreover, only few experimental parameters were evaluated in each study.…”

Section: Introductionmentioning

confidence: 99%

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Design of experiments (DOE) for the optimization of hydrothermal synthesis of hydroxyapatite nanoparticles

Sadat‐Shojai¹,

Atai²,

Nodehi³

2011

J. Braz. Chem. Soc.

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O objetivo deste trabalho foi investigar a influência de diversos parâmetros de reação sobre as propriedades de nanopartículas de hidroxiapatita (HAp) preparadas pelo método hidrotérmico. Os dados da literatura descrevem condições experimentais variadas para a síntese hidrotérmica de HAp. Uma abordagem específica foi então utilizada para avaliar os fatores estatisticamente influentes entre aqueles descritos na literatura. O papel de cada parâmetro experimental também foi discutido no contexto da nucleação de partículas e do mecanismo de crescimento de cristais. Dentro das variáveis selecionadas, temperatura e pH foram os fatores que mais afetaram a composição e morfologia da HAp. Além disso, neste estudo, diferentes morfologias variando de nanopartículas cilíndricas do tipo bastonete a esféricas com várias características foram obtidas com sucesso, o que pode ser aplicável na preparação de várias biocerâmicas de HAp.The aim of this work was to investigate the influence of different reaction parameters on the properties of hydroxyapatite (HAp) nanoparticles prepared by the hydrothermal method. The literature data describe widely different experimental conditions for the hydrothermal synthesis of HAp. A specific approach was therefore used to evaluate the statistically influential factors among those described in the literature. The role of each experimental parameter was also discussed within the framework of particle nucleation and crystal growth mechanism. Among the selected variables, temperature and pH were found to be the most significant factors affecting the composition and morphology of the HAp. Moreover, in the present study, different morphologies ranging from rod-like to spherical nanoparticles with various characteristics were successfully obtained, which can be applicable for the preparation of various HAp bioceramics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Design of experiments (DOE) for the optimization of hydrothermal synthesis of hydroxyapatite nanoparticles

Sadat‐Shojai¹,

Atai²,

Nodehi³

2011

J. Braz. Chem. Soc.

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Synthesis and Characterization of Hydroxyapatite and Hydroxyapatite‐Based Catalysts

Jemli¹,

Abdelouahdi²,

Minh

et al. 2022

Design and Applications of Hydroxyapatite‐Based Catalysts

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Molecular Understanding of the Bulk Composition of Crystalline Nonstoichiometric Hydroxyapatites: Application to the Rationalization of Structure–Reactivity Relationships

et al. 2016

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International audienceCrystalline hydroxyapatite samples (HAps) have been prepared by using the co-precipitation method under various pH conditions, leading to nonstoichiometric solids (1.65 < Ca/P < 1.77). The aim of this study was to rationalize the sensitivity of the catalytic activity of HAps to their bulk compositions going from the macroscopic level expressed by the Ca/P ratio to the molecular level properties of the bulk. From DRIFT, 31P NMR and Raman characterizations, hydroxyapatites were obtained with a range of structural defects compared with the ideal stoichiometric compound. If the amount of HPO42– and B-type carbonates directly impacts the Ca/P ratio, it is not the case for A-type carbonates. All these defects, and especially the A-type carbonates, participate in the modulation of OH content inside the channels. Irrespective of the Ca/P values, the OH concentration appears to be perfectly related to the surface basic reactivity measured through 2-methyl-3-butyn-2-ol (MBOH) conversion. Thus, except for the similar carbonate content (in cases of low Ca/P values), the Ca/P ratio is not sufficient to predict the catalytic behavior of all HAps synthesized under various conditions: in the case of variable carbonate content monitored under different pH conditions, a larger range of Ca/P ratio can be obtained including over-stoichiometric HAps samples (Ca/P > 1.67), and the bulk OH concentration becomes a much better descriptor than the Ca/P ratio to account for the basic reactivity

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Hydrothermal synthesis of hydroxyapatite

Cited by 123 publications

References 8 publications

Design of experiments (DOE) for the optimization of hydrothermal synthesis of hydroxyapatite nanoparticles

Design of experiments (DOE) for the optimization of hydrothermal synthesis of hydroxyapatite nanoparticles

Synthesis and Characterization of Hydroxyapatite and Hydroxyapatite‐Based Catalysts

Molecular Understanding of the Bulk Composition of Crystalline Nonstoichiometric Hydroxyapatites: Application to the Rationalization of Structure–Reactivity Relationships

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