Hydrothermal synthesis of defective TiO₂nanoparticles for long-wavelength visible light-photocatalytic killing of cancer cells

Abstract

Newly fabricated d-TiO2 NPs were demonstrated to be efficient in long wavelength visible light-triggered killing of cancer cells.

Ag/AgFeO2: An Outstanding Magnetically Responsive Photocatalyst for HeLa Cell Eradication

“… 23 − 32 The synthetic methods for these and other photocatalysts often involve complicated procedures, 23 − 27 , 29 − 38 long preparation times, 23 , 26 , 27 , 29 , 31 − 37 and/or high temperatures/pressures. 10 , 23 , 26 − 29 , 31 , 32 , 34 , 37 , 38 Furthermore, the HeLa cell treatment utilizing the above-mentioned photocatalysts often require high photocatalyst dosages (>100 μg/mL) 23 , 27 , 28 , 30 , 31 , 34 , 35 , 38 and long treatment times (>100 min). 23 , 28 , 31 , 38 In this study, we developed a simple one-step carrier-solvent-assisted interfacial reaction process that can produce Ag/AgFeO 2 composite NCs of less than 10 nm in size at room temperature under ambient pressure with only 1 min reaction time.…”

Nanoparticles in biomedical applications

“…The results showed the generation of ROS and also singlet oxygen, after irradiation with long-wavelength visible light, which lead to the destruction of the cancerous cells. Defective TiO 2 (d-TiO 2 ) nanoparticles show good potential for use in PDT for cancer treatment [185].…”

“…Lee et al [185] researched the use of defective TiO 2 (d-TiO 2 ) nanoparticles for the photocatalytic destruction of human cervical (HeLa) cancer cells and hepatocellular (liver) (Hep-G2) cancer cells using long wave-length visible light. The defective TiO 2 (d-TiO 2 ) nanoparticles were synthesised via sol-gel and hydrothermal reactions through the formation of liposome-TiO 2 composites.…”

“…TiO 2 nanoparticles have many unique properties such as biocompatibility, chemical stability and optical properties [173]. It is because of these properties that there has been a recent increase in the use of TiO 2 nanoparticles in biomedical applications such as drug delivery [174][175][176][177][178][179], bioimaging [175], photoablation therapy [180][181][182][183][184][185] and biosensors [186,187], which will be discussed further in Section 4. Other metal oxide nanoparticles that are gaining interest in biomedical applications are cerium oxide (CeO 2 ) nanoparticles or nanoceria.…”

“…TiO 2 has many unique features such as good biocompatibility, low toxicity, chemical stability and photocatalytic properties which makes it an attractive material for use in the biomedical industry. Due to its unique properties, lots of research has been carried out on using TiO 2 nanoparticles in different biomedical applications such as drug delivery, PDT, cell imaging, biosensors and genetic engineering [173][174][175][176][177][178][179][180][181][182][183][184][185][186][187]. In this review, we will discuss the use of TiO 2 nanoparticles in targeted drug delivery and PDT.…”