Hydrophobin-Coated Perfluorocarbon Microbubbles with Strong Non-Linear Acoustic Response
Valentina Dichiarante,
Giuseppina Salzano,
Philippe Bussat
et al.
Abstract:Gas-filled microbubbles are well-established contrast agents for ultrasound imaging and widely studied as delivery systems for theranostics. Herein, we have demonstrated the promising potential of the hydrophobin HFBII—a fungal amphiphilic protein—in stabilizing microbubbles with various fluorinated core gases. A thorough screening of several experimental parameters was performed to find the optimized conditions regarding the preparation technique, type of core gas, HFBII initial concentration, and protein dis… Show more
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