Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute

Hyperbranched Polyglycerol is an Efficacious and Biocompatible Novel Osmotic Agent in a Rodent Model of Peritoneal Dialysis

“…Hyperbranched polyglycerol can be precisely synthesized over a wide range of molecular weights and is chemically stable as a narrow distributed polymer in aqueous solution (11)(12)(13). It is highly hydrophilic and water-soluble (>400 mg/mL), with a very low intrinsic viscosity (4 -7 mL g -1 ), and therefore large amounts of the polymer can easily be dissolved in water (13,14). It also has multiple hydroxyl groups per molecule of polymer and exists at physiologic pH in aqueous solution (14).…”

“…It is highly hydrophilic and water-soluble (>400 mg/mL), with a very low intrinsic viscosity (4 -7 mL g -1 ), and therefore large amounts of the polymer can easily be dissolved in water (13,14). It also has multiple hydroxyl groups per molecule of polymer and exists at physiologic pH in aqueous solution (14). In experimental studies, we demonstrated that HPG and its derivative molecules are highly blood-compatible, nonimmunogenic, and nontoxic (14)(15)(16)(17).…”

“…Unlike other polymers, HPG has been shown to have very limited organ accumulation after intravenous injection (14,18). It does not activate the platelet, coagulation, or complement systems (14). Taken together, these properties make HPG a promising candidate for use as an osmotic agent in PD.…”

Hyperbranched aliphatic polyether polyols

“…196 Just recently, the same group suggested the application of an hbPG derivative as tissue sealant and in the self-assembly of lipid nanostructures. hbPG functionalized with choline phosphate (CP) at the surface binds electrostatically to a variety of phosphatidylcholine (PC)-rich cell membranes and to PCcontaining liposomes.…”

Synthesis of thermoresponsive unimolecular polymeric micelles with a hydrophilic hyperbranched poly(glycidol) core

“…48 Up to now, water-soluble hyperbranched poly(glycidol) (HPG) has been used widely to prepare amphiphilic molecular nanocapsules because it is highly biocompatible and without evident animal toxicity, which could encapsulate polar guests from water. 34,[49][50][51][52][53][54][55][56][57][58][59][60] Peng et al 50 have obtained star-hyperbranched block copolymers of HPG-b-polystyrene using atom transfer radical polymerization; these have good structural formation for ionic conductivity. Brooks et al 60 have reported the use of amphiphilic HPG as nanoreators for unimolecular elimination reactions.…”