Hydrophobic stripping voltammetry using a lipid-modified glassy carbon electrode

Chastel, Olivier; Kauffmann, J.M.; Patriarche, Gaston; Christian, Gary D.

doi:10.1021/ac00177a018

Cited by 55 publications

(16 citation statements)

References 18 publications

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“…This control can be effected in different ways, mainly by using selective coatings, tailored to afford access to a desired analyte (and to keep other undesired species away from the electrode surface) or by the immobilization (electrodeposition, chemisorption or covalent bonding) of a chemically active catalyst, which is able to change the reaction potential and/or to improve the electrochemical signal. 3 Coatings with different discriminative properties, such as size, 4 charge, 5 or polarity, 6 have been developed to yield significant improvements in in vivo monitoring of primary neurotransmitters, 7 amperometric detection for liquid chromatography or flow injection systems, 4,5 enzymatic and nonenzymatic sensing of glucose, 8 or anodic stripping measurements of low levels of metals. 9 A remarkable number of chemically active catalysts have been used (virtually any redox material can be explored) and research in this area is still growing vigorously.…”

Section: Introductionmentioning

confidence: 99%

Modified microelectrodes and multivariate calibration for flow injection amperometric simultaneous determination of ascorbic acid, dopamine, epinephrine and dipyrone

Matos

Angnes

Araújo

et al. 2000

Analyst

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Flow injection amperometric quantification of ascorbic acid (AA), dopamine (DA), epinephrine (EP) and dipyrone (DI) in mixtures (in the microgram g-1 range) was successfully performed by using an array of microelectrodes with units modified by the electrodeposition of different noble metals, together with multivariate calibration analysis. The four groups of microelectrodes utilized included a pure gold electrode and electrodes modified by electrodeposition of platinum, palladium or a mixture of platinum + palladium. The array of microelectrodes was inserted in a flow cell and the amperometric data acquisition was performed with a four-channel potentiostat. The analysis of the resulting signals was carried out by a multivariate calibration method, using a group of 16 standard mixtures selected by a two-level factorial design. The analysis of synthetic samples and pharmaceutical compounds containing AA and DI led to very similar values to those obtained by the classical iodimetric analysis. The average absolute errors (in microgram g-1) calculated for each analyte were 0.3, 0.2, 0.4 and 0.4 for AA, DA, EP and DI, respectively.

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Section: Introductionmentioning

confidence: 99%

Modified microelectrodes and multivariate calibration for flow injection amperometric simultaneous determination of ascorbic acid, dopamine, epinephrine and dipyrone

Matos

Angnes

Araújo

et al. 2000

Analyst

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“…This kind of interaction has a purely chemical rather than electrochemical mechanism [22] and usually can be explained by several processes: exchange phenomena [23], hydrophobic-hydrophylic interaction [24], covalent binding [9] and/or complex formation reactions [25].…”

Section: Discussionmentioning

confidence: 99%

Studies of the Interaction Between Metalloporphyrin Films and Phenols in a Preconcentration Type Sensor

et al. 1998

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Metalloporphyrins have been used as sensors to detect phenols. We describe several experiments that indicate that the increment of current response is due to a preconcentration effect of the phenolic analyte in the modifying layer. The aromatic structure seems to be crucial to achieve this goal, indicating p-p interaction. The electrical response to phenols of a variety of poly[M-(PPIX)] films, M ¼ Ni II , Co II and Cu II was measured suggesting an axial ligand-metalloporphyrin interaction. The IR spectras of p-nitrophenol with and without porphyrins were obtained showing a gradual decrease of the signal at 1205.6 cm ¹1 , corresponding to C-O stretching and the presence of two new peaks (1236.7, 1167.4 cm ¹1 ). Further the signal at 1345 cm ¹1 corresponding to symmetric (ArNO 2 ) N-O stretching, remains unchanged. Therefore, these results indicate that the -C-OH group is involved in the binding.

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“…This is probably due to the fact that the enzyme is not electronically conductive and also it is difficult to immobilize an enzyme on the electrode surface. So far, biological lipids have been used to modify the electrode, and the modified electrode shows a selectivity for hydrophobic molecules because the lipid molecule is hydrophobic (37)(38)(39).…”

Section: Electrochemical Behavior Of Ppy-god Film Electrode With Pharmentioning

confidence: 99%

Polypyrrole Film Electrode Incorporating Glucose Oxidase

Sun

Tachikawa

1992

ACS Symposium Series

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Polypyrrole thin film doped with glucose oxidase (PPy-GOD) has been prepared on a glassy carbon electrode by the electrochemical polymerization of the pyrrole monomer in the solution of glucose oxidase enzyme in the absence of other supporting electrolytes. The cyclic voltammetry of the PPy-GOD film electrode shows electrochemical activity which is mainly due to the redox reaction of the PPy in the film. Both in situ Raman and in situ UV-visible spectroscopic results also show the formation of the PPy film, which can be oxidized and reduced by the application of the redox potential. A good catalytic response to the glucose and an electrochemical selectivity to some hydrophilic pharmaceutical drugs are seen at the PPy-GOD film electrode.In recent years the electrochemistry of the enzyme membrane has been a subject of great interest due to its significance in both theories and practical applications to biosensors (i-5). Since the enzyme electrode was first proposed and prepared by Clark et al. (6) and Updike et al. (7), enzyme-based biosensors have become a widely interested research field. Research efforts have been directed toward improved designs of the electrode and the necessary membrane materials required for the proper operation of sensors. Different methods have been developed for immobilizing the enzyme on the electrode surface, such as covalent and adsorptive couplings (8Ί2) of the enzymes to the electrode surface, entrapment of the enzymes in the carbon paste mixture (73), etc. The entrapment of the enzyme into a conducting polymer has become an attractive method (14-22) because of the conducting nature of the polymer matrix and of the easy preparation procedure of the enzyme electrode. The entrapment of enzymes in the polypyrrole film provides a simple way of enzyme immobilization for the construction of a biosensor. It is known that the PPy-

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Hydrophobic stripping voltammetry using a lipid-modified glassy carbon electrode

Cited by 55 publications

References 18 publications

Modified microelectrodes and multivariate calibration for flow injection amperometric simultaneous determination of ascorbic acid, dopamine, epinephrine and dipyrone

Modified microelectrodes and multivariate calibration for flow injection amperometric simultaneous determination of ascorbic acid, dopamine, epinephrine and dipyrone

Studies of the Interaction Between Metalloporphyrin Films and Phenols in a Preconcentration Type Sensor

Polypyrrole Film Electrode Incorporating Glucose Oxidase

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