Hydrophobic paper-based SERS platform for direct-droplet quantitative determination of melamine

Zhang, Chenmeng; You, Tingting; Yang, Nan; Gao, Yukun; Jiang, Li Jun; Yin, Penggang

doi:10.1016/j.foodchem.2019.02.094

Cited by 102 publications

(34 citation statements)

References 35 publications

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“…However, melamine is toxic and can cause many serious health issues, including reproduction damage, bladder infection, kidney stones, acute kidney failure, bladder cancer, and infant death [ 60 ]. The detection of melamine in milk samples (non-detectable) requires an extremely high resolution, and hence recent microfluidic devices for melamine analysis generally use high-sensitivity detection techniques such as electrochemistry (EC) [ 61 , 62 ], colorimetric AuNP sensing [ 63 , 64 ], surface-enhanced Raman scattering (SERS) [ 65 , 66 ], and immunosensor [ 67 , 68 ]. For example, Li et al [ 62 ] developed a microfluidic EC DNA-based sensor platform for continuous, real-time melamine detection in whole milk samples.…”

Section: Microfluidic Platforms For Milk Sample Analysismentioning

confidence: 99%

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Lee

Kung

et al. 2021

Micromachines

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Milk is a necessity for human life. However, it is susceptible to contamination and adulteration. Microfluidic analysis devices have attracted significant attention for the high-throughput quality inspection and contaminant analysis of milk samples in recent years. This review describes the major proposals presented in the literature for the pretreatment, contaminant detection, and quality inspection of milk samples using microfluidic lab-on-a-chip and lab-on-paper platforms in the past five years. The review focuses on the sample separation, sample extraction, and sample preconcentration/amplification steps of the pretreatment process and the determination of aflatoxins, antibiotics, drugs, melamine, and foodborne pathogens in the detection process. Recent proposals for the general quality inspection of milk samples, including the viscosity and presence of adulteration, are also discussed. The review concludes with a brief perspective on the challenges facing the future development of microfluidic devices for the analysis of milk samples in the coming years.

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Section: Microfluidic Platforms For Milk Sample Analysismentioning

confidence: 99%

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Lee

Kung

et al. 2021

Micromachines

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“…After the cooperation of a surface plasmon polarization (SPP) mechanism with a hotspot effect existing between the metallic nanogaps [3], SERS can increase the sensitivity up to 10 8 -fold in the best case, enabling the detection of even a single molecule [3,4]. It could be also applicable to the analysis of foods [4][5][6][7][8], environmental pollutants [4], and various biological samples 10 8 -fold in the best case, enabling the detection of even a single molecule [3,4]. It could be also applicable to the analysis of foods [4][5][6][7][8], environmental pollutants [4], and various biological samples in life sciences [2,3,9].…”

Section: Introductionmentioning

confidence: 99%

“…After the cooperation of a surface plasmon polarization (SPP) mechanism with a hotspot effect existing between the metallic nanogaps [ 3 ], SERS can increase the sensitivity up to 10 8 -fold in the best case, enabling the detection of even a single molecule [ 3 , 4 ]. It could be also applicable to the analysis of foods [ 4 , 5 , 6 , 7 , 8 ], environmental pollutants [ 4 ], and various biological samples in life sciences [ 2 , 3 , 9 ]. However, in these practical applications, SERS easily encounters the issues of unrepeatable and/or irreproducible measurements.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Monolayer Photonic Crystals from Ag Nanobulge-Deposited SiO2 Particles as Substrates for Reproducible SERS Assay of Trace Thiol Pesticide

Zhang

Chen

2020

Nanomaterials

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Surface-enhanced Raman scattering (SERS) greatly increases the detection sensitivity of Raman scattering. However, its real applications are often degraded due to the unrepeatable preparation of SERS substrates. Herein presented is a very facile and cost-effective method to reproducibly produce a novel type of SERS substrate, a monolayer photonic crystal (PC). With a building block of laboratory-prepared monodisperse SiO2 particles deposited with space-tunable silver nanobulges (SiO2@nAg), a PC substrate was first assembled at the air–water interface through needle tip flowing, then transferred onto a silicon slide by a pulling technique. The transferred monolayer PCs were characterized by SEM and AFM to have a hexagonal close-packed lattice. They could increase Raman scattering intensity by up to 2.2 × 107-fold, as tested with p-aminothiophenol. The relative standard deviations were all below 5% among different substrates or among different locations on the same substrate. The excellent reproducibility was ascribed to the highly ordered structure of PCs, while the very high sensitivity was attributed to the strong hotspot effect caused by the appropriately high density of nanobulges deposited on SiO2 particles and by a closed lattice. The PC substrates were validated to be applicable to the SERS assay of trace thiol pesticides. Thiram pesticide is an example determined in apple juice samples at a concentration 102-fold lower than the food safety standard of China. This method is extendable to the analysis of other Raman-active thiol chemicals in different samples, and the substrate preparation approach can be modified for the fabrication of more PC substrates from other metallic nanobulge-deposited particles rather than silica only.

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“…In addition, the adjacent nanoparticles create hotspots, providing an enhanced SERS signal. [13][14][15][16] Gold nanoparticles were widely investigated for several biological and chemical sensing applications, due to their unique chemical and physical properties including ease of synthesis, biocompatibility, chemical stability, and plasmonic tunability. [17][18][19][20][21] Moreover, surface-modied gold nanoparticles can conjugate with various biomolecules, such as antibodies, enzymes, oligonucleotides, which provide an opportunity to develop a new biosensor platform with high specicity and selectivity to detect biological and chemical molecules.…”

Section: Introductionmentioning

confidence: 99%

High-sensitivity SERS based sensing on the labeling side of glass slides using low branched gold nanoparticles prepared with surfactant-free synthesis

Tezcan

Hsu

2020

RSC Adv.

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Hydrophobic paper-based SERS platform for direct-droplet quantitative determination of melamine

Cited by 102 publications

References 35 publications

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Preparation of Monolayer Photonic Crystals from Ag Nanobulge-Deposited SiO2 Particles as Substrates for Reproducible SERS Assay of Trace Thiol Pesticide

High-sensitivity SERS based sensing on the labeling side of glass slides using low branched gold nanoparticles prepared with surfactant-free synthesis

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