Hydrophobic Organic Matter Promotes Coxsackievirus B5 Stabilization and Protection from Heat

Waldman, Prunelle; Lucas, Françoise; Varrault, Gilles; Moulin, Laurent; Wurtzer, Sébastien

doi:10.1007/s12560-019-09418-9

Cited by 7 publications

(6 citation statements)

References 45 publications

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“…Heat inactivation is commonly used for studying virus survival in water. In low temperature range (<50°C), the inactivation of naked viruses mainly comes from the denaturation of capsids ( Waldman et al, 2020 , 2017 ). However little is known concerning enveloped viruses.…”

Section: Resultsmentioning

confidence: 99%

Several forms of SARS-CoV-2 RNA can be detected in wastewaters: Implication for wastewater-based epidemiology and risk assessment

et al. 2021

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The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a public health emergency of international concern. Although SARS-CoV-2 is considered to be mainly transmitted by inhalation of contaminated droplets and aerosols, SARS-CoV-2 is also detected in human faeces and to a less extent in urine, and in raw wastewaters (to date viral RNA only) suggesting that other routes of infection may exist. Monitoring SARS-CoV-2 genomes in wastewaters has been proposed as a complementary approach for tracing the dynamics of virus transmission within human population connected to wastewater network. The understanding on SARS-CoV-2 transmission through wastewater surveillance, the development of epidemic modeling and the evaluation of SARS-CoV-2 transmission from contaminated wastewater are largely limited by our knowledge on viral RNA genome persistence and virus infectivity preservation in such an environment. Using an integrity based RT-qPCR assay this study led to the discovery that SARS-CoV-2 RNA can persist under several forms in wastewaters, which provides important information on the presence of SARS-CoV-2 in raw wastewaters and associated risk assessment.

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Section: Resultsmentioning

confidence: 99%

Several forms of SARS-CoV-2 RNA can be detected in wastewaters: Implication for wastewater-based epidemiology and risk assessment

et al. 2021

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“…Heat inactivation is commonly used for studying virus survival in water. In low temperature range (<50°C), the inactivation of naked viruses mainly comes from the denaturation of capsids (Waldman et al, 2020(Waldman et al, , 2017. However little is known concerning enveloped viruses.…”

Section: Temperature-based Inactivation Unrevealed Different Status Fmentioning

confidence: 99%

Several forms of SARS-CoV-2 RNA can be detected in wastewaters : implication for wastewater-based epidemiology and risk assessment

Wurtzer

Waldman

Ferrier-Rembert³

et al. 2020

Preprint

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The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a public health emergency of international concern. Although SARS-CoV-2 is considered to be mainly transmitted by inhalation of contaminated droplets and aerosols, SARS-CoV-2 is also detected in human feces and in raw wastewaters suggesting that other routes of infection may exist. Monitoring SARS-CoV-2 genomes in wastewaters has been proposed as a complementary approach for tracing the dynamics of virus transmission within human population connected to wastewater network. The understanding on SARS-CoV-2 transmission through wastewater surveillance, the development of epidemic modeling and the evaluation of SARS-CoV-2 transmission from contaminated wastewater are largely limited by our knowledge on viral RNA genome persistence and virus infectivity preservation in such an environment. Using an integrity based RT-qPCR assay this study led to the discovery that SARS-CoV-2 RNA can persist under several forms in wastewaters, which provides important information on the presence of SARS-CoV-2 in raw wastewaters and associated risk assessment.Graphical Abstract

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“…In other studies, it was found that removal and inactivation of viruses in different granular media is non-linear, reflecting chiefly the heterogeneity within soil grains and differences in the physical and chemical structure of viral particles ( Betancourt et al, 2019 ; Schijven and Hassanizadeh, 2000 ). Overall, the impact of environmental parameters on virus persistence in the environment has received little attention ( Waldman et al, 2020 ). Yet, there is some recent experience on the influence of environmental parameters against the action of biocides (due to adsorption, galvanic deposition, etc) in recycled hygiene and potable water samples under conditions prevailing in the International Space Station ( Petala et al, 2017 .…”

Section: Introductionmentioning

confidence: 99%

A physicochemical model for rationalizing SARS-CoV-2 concentration in sewage. Case study: The city of Thessaloniki in Greece

Petala

Dafou

Kostoglou

et al. 2021

Science of The Total Environment

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Detection of SARS-CoV-2 in sewage has been employed by several researchers as an alternative early warning indicator of virus spreading in communities, covering both symptomatic and asymptomatic cases. A factor that can seriously mislead the quantitative measurement of viral copies in sewage is the adsorption of virus fragments onto the highly porous solids suspended in wastewater, making them inaccessible. This depends not only on the available amount of suspended solids, but also on the amount of other dissolved chemicals which may influence the capacity of adsorption. On this account, the present work develops a mathematical framework, at various degrees of spatial complexity, of a physicochemical model that rationalizes the quantitative measurements of total virus fragments in sewage as regards the adsorption of virus onto suspended solids and the effect of dissolved chemicals on it. The city of Thessaloniki in Greece is employed as a convenient case study to determine the values of model variables. The present data indicate the ratio of the specific absorption (UV 254 /DOC) over the dissolved oxygen (DO) as the parameter with the highest correlation with viral copies. This implies a strong effect on viral inaccessibility in sewage caused (i) by the presence of humic-like substances and (ii) by virus decay due to oxidation and metabolic activity of bacteria. The present results suggest days where many fold corrections in the measurement of viral copies should be applied. As a result, although the detected RNA load in June 2020 is similar to that in April 2020, virus shedding in the city is about 5 times lower in June than in April, in line with the very low SARS-CoV-2 incidence and hospital admissions for COVID-19 in Thessaloniki in June.

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Hydrophobic Organic Matter Promotes Coxsackievirus B5 Stabilization and Protection from Heat

Cited by 7 publications

References 45 publications

Several forms of SARS-CoV-2 RNA can be detected in wastewaters: Implication for wastewater-based epidemiology and risk assessment

Several forms of SARS-CoV-2 RNA can be detected in wastewaters: Implication for wastewater-based epidemiology and risk assessment

Several forms of SARS-CoV-2 RNA can be detected in wastewaters : implication for wastewater-based epidemiology and risk assessment

A physicochemical model for rationalizing SARS-CoV-2 concentration in sewage. Case study: The city of Thessaloniki in Greece

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