Hydrophobic deep eutectic solvents as water-immiscible extractants

Osch, Dannie J. G. P. van; Zubeir, Lawien F.; Bruinhorst, Adriaan van den; Rocha, Marisa A.A.; Kroon, MC Maaike

doi:10.1039/c5gc01451d

Cited by 657 publications

(488 citation statements)

References 24 publications

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“…Furthermore, the elongation of the side chain rightfully leads to decreased densities (thus to less dense systems) probably due to the increased space requirement of the longer side chains. This trend is confirmed by the experimental hydrophobic DES study of Kroon and coworkers …”

Section: Figuresupporting

confidence: 74%

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Strong Microheterogeneity in Novel Deep Eutectic Solvents

et al. 2019

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With the increasing application of template assisted syntheses in deep eutectic solvents and successful application of hydrophobic deep eutectic solvents in extraction processes, where microheterogeneity plays a major role, suggestions for novel deep eutectic solvents which exhibit strong microheterogeneity are desirable. Therefore, classical molecular dynamics simulations were carried out on deep eutectic solvent systems constructed of choline chloride and some of its derivatives mixed with ethylene glycol in a molar composition of 1 : 2 since this is the optimal parent composition. The derivatives consisted of a series of elongated alkyl side chains and elongated alcohol side chains. Of these series only choline chloride ethylene glycol has been investigated experimentally, the other systems are suggested and theoretically investigated as possible target for synthesis. Our domain analysis supported by the clear distinction of polar and nonpolar parts from the electrostatic potentials reveals that strong microheterogeneity within these novel hypothetical deep eutectic solvents exists. Rather stretched than crumbled side chains maximize possible interaction sites for both polar and nonpolar parts which make the suggested compounds valuable objectives for experiments in order to exploit the microheterogeneity in deep eutectic solvents.

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Section: Figuresupporting

confidence: 74%

“…MH studies in DES started when hydrophobic DES were presented and successfully applied in extraction processes . A nanoscale spatial heterogeneity was found from molecular dynamics simulations of acetamide with

{Li}^{+} {ClO}_{4}^{-}

and propionamide with

{Li}^{+} {ClO}_{4}^{-}

.…”

Section: Figurementioning

confidence: 99%

Strong Microheterogeneity in Novel Deep Eutectic Solvents

et al. 2019

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“…This is necessary to evaluate the behavior of hydrophobic DES with water. We have applied the first three techniques in our previous works on the extraction of fatty acids from aqueous solutions using the same DESs reported here 16 and extraction of metal ions with DESs. 20 Therefore, as an extension of our former works, the pH of the water phase after being mixed with the investigated DESs has been measured.…”

Section: Resultsmentioning

confidence: 99%

Carbon Dioxide Solubilities in Decanoic Acid-Based Hydrophobic Deep Eutectic Solvents

Osch²,

et al. 2018

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The solubility of CO2 in hydrophobic deep eutectic solvents (DESs) has been measured for the first time. Six different hydrophobic DESs are studied in the temperature range from 298 to 323 K and at CO2 pressures up to 2 MPa. The results are evaluated by comparing the solubility data with existing hydrophilic DESs and currently applied physical solvents and fluorinated ionic liquids. The DESs are prepared by mixing decanoic acid with a quaternary ammonium salt with different halide anions and alkyl chain lengths. The measured CO2 solubilities are similar to those found in renowned fluorinated ILs, while the heats of CO2 absorption are in the range of nonpolar solvents. The presented DESs show good potential to be used as CO2 capture agents.

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“…Comparison among DES-1, DES-2, and DES-3 indicated that the extraction yield with DES-1 was maximal. When the HBD/HBA molar ratio decreased from 2 : 1 to 1 : 2, the amounts of HBA increased, and thus resulted in the decrease in viscosity and surface tension, which would enhance their extraction efficiency [25,26].…”

Section: Comparison Of the Extractability Of Dessmentioning

confidence: 99%

Deep Eutectic Solvent-Based Microwave-Assisted Extraction of Baicalin from Scutellaria baicalensis Georgi

Wang

Cheng

et al. 2018

Journal of Chemistry

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Deep eutectic solvents (DESs) have attracted significant attention as green media for the extraction and separation of natural compounds from Chinese medicine. In this study, a hydrophobic DESs-based microwave-assisted extraction (MAE) was successfully used to efficiently extract baicalin from Scutellaria baicalensis Georgi. Firstly, DecA: N 4444 -Cl (DES-1 , molar ratio 1 : 2) was screened and selected as the most appropriate DES by comparing the extraction yield in different hydrophobic DESs. Based on the extraction yield of baicalin, response surface methodology (RSM) was employed to model and optimize the parameters (extraction temperature, liquid-solid ratio, and extraction time). Furthermore, the maximum yield of 106.96 mg⋅g −1 was achieved under optimum conditions in DES-containing aqueous solutions (33 vol% water content), which reached a similar level that was conducted using the pharmacopoeia procedure (104.94 mg⋅g −1 ). These results indicated that the proposed method is an excellent alternative for the extraction of baicalin.

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Hydrophobic deep eutectic solvents as water-immiscible extractants

Abstract: Hydrophobic deep eutectic solvents consisting of decanoic acid and various quaternary ammonium salts are presented and evaluated as extractants.

Cited by 657 publications

References 24 publications

Strong Microheterogeneity in Novel Deep Eutectic Solvents

Strong Microheterogeneity in Novel Deep Eutectic Solvents

Carbon Dioxide Solubilities in Decanoic Acid-Based Hydrophobic Deep Eutectic Solvents

Deep Eutectic Solvent-Based Microwave-Assisted Extraction of Baicalin from Scutellaria baicalensis Georgi

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