Hydrophobic C-Terminal Peptide Analog Aβ31–41 Protects the Neurons from Aβ-Induced Toxicity
Rathnam Mallesh,
Juhee Khan,
Prabir Kumar Gharai
et al.
Abstract:Spontaneous aggregation of amyloid
beta (Aβ) leads
to the
formation of neurotoxic senile plaque considered as the most crucial
event in Alzheimer’s disease (AD) progression. Inhibition or
disruption of this deadly aggregate formation is one of the most efficient
strategies for the development of potential therapeutics, and extensive
research is in progress by various research groups. In this direction,
the development of a peptide analogous to that of the native Aβ
peptide is an attractive strategy. Based on t… Show more
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