Hydrophobic agave fructans for sustained drug delivery to the human colon

Miramontes-Corona, Carmen; Escalante, Alfredo; Delgado, Ezequiel; Corona-González, Rosa Isela; Vázquez‐Torres, Humberto; Toríz, Guillermo

doi:10.1016/j.reactfunctpolym.2019.104396

Cited by 26 publications

(18 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, they discovered that in the region of 3500 cm −1 , the modified samples' band intensities decreased. This result is consistent with that reported by Miramontes-Corona et al (2020), who studied acetylation in fructans from A. tequilana Weber and discovered that this modification aided in the encapsulation of a drug (ibuprofen).…”

Section: Chemical Modification Of Agave Fructans By Acetylationsupporting

confidence: 92%

Evaluation of the fermentation of acetylated agave fructans (agavins), with Saccharomyces boulardii as a probiotic

Buitrago-Arias

Londoño-Moreno

Ávila-Reyes

et al. 2021

RMIQ

View full text Add to dashboard Cite

Section: Chemical Modification Of Agave Fructans By Acetylationsupporting

confidence: 92%

Evaluation of the fermentation of acetylated agave fructans (agavins), with Saccharomyces boulardii as a probiotic

Buitrago-Arias

Londoño-Moreno

Ávila-Reyes

et al. 2021

RMIQ

View full text Add to dashboard Cite

“…Particularly, polysaccharides such as pectin, guar gum, inulin, and chitosan have been used in colon-targeted drug delivery systems, because they can retain their integrity in the upper GI tract but are metabolized by colonic microflora to release the entrapped drug [55]. Recently, new polysaccharides including arabinoxylans and agave fructans are also being explored for colonic drug delivery systems [56,57]. Furthermore, structural modifications or derivatives of polysaccharides can improve drug release behavior, stability, and site specificity [58].…”

Section: Polysaccharide-based Systemsmentioning

confidence: 99%

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

et al. 2020

View full text Add to dashboard Cite

Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies.

show abstract

“…Acetylation also led to a large decrease in the glass transition temperature and significant improvement of stability at gastric pH. The prepared acetylated fructans retained the characteristic groups of native fructans such as hydroxyl, methylene, and C–O–C, although some significant changes also took place in the acetylated fructans such as those found in the FTIR spectra: O–H region (3600−3000 cm −1 ) disappeared, and the intensities of stretching vibrations of CH 3 , C–O, and C = O groups (1220, 1370, and 1740 cm −1 ) increased (Miramontes‐Corona et al., 2020). Therefore, acetylated fructans can allow efficient delivery of hydrophobic bioactive substances/drugs to the colon with longer bioavailability during delivery and release (Miramontes‐Corona et al., 2020).…”

Section: Production Of Garlic Polysaccharides and Oligosaccharidesmentioning

confidence: 98%

Bioactive polysaccharides and oligosaccharides from garlic (Allium sativum L.): Production, physicochemical and biological properties, and structure–function relationships

Qiu

Qiao

Zhang

et al. 2022

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Garlic is a common food, and many of its biological functions are attributed to its components including functional carbohydrates. Garlic polysaccharides and oligosaccharides as main components are understudied but have future value due to the growing demand for bioactive polysaccharides/oligosaccharides from natural sources. Garlic polysaccharides have molecular weights of 1 × 103 to 2 × 106 Da, containing small amounts of pectins and fructooligosaccharides and large amounts of inulin‐type fructans ((2→1)‐linked β‐d‐Fruf backbones alone or with attached (2→6)‐linked β‐d‐Fruf branched chains). This article provides a detailed review of research progress and identifies knowledge gaps in extraction, production, composition, molecular characteristics, structural features, physicochemical properties, bioactivities, and structure–function relationships of garlic polysaccharides/oligosaccharides. Whether the extraction processes, synthesis approaches, and modification methods established for other non‐garlic polysaccharides are also effective for garlic polysaccharides/oligosaccharides (to preserve their desired molecular structures and bioactivities) requires verification. The metabolic processes of ingested garlic polysaccharides/oligosaccharides (as food ingredients/dietary supplements), their modes of action in healthy humans or populations with chronic conditions, and molecular/chain organization–bioactivity relationships remain unclear. Future research directions related to garlic polysaccharides/oligosaccharides are discussed.

show abstract

Hydrophobic agave fructans for sustained drug delivery to the human colon

Cited by 26 publications

References 45 publications

Evaluation of the fermentation of acetylated agave fructans (agavins), with Saccharomyces boulardii as a probiotic

Evaluation of the fermentation of acetylated agave fructans (agavins), with Saccharomyces boulardii as a probiotic

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Bioactive polysaccharides and oligosaccharides from garlic (Allium sativum L.): Production, physicochemical and biological properties, and structure–function relationships

Contact Info

Product

Resources

About