Hydrophilic Monodisperse Magnetic Nanoparticles Protected by an Amphiphilic Alternating Copolymer

Abstract

Iron oxide nanoparticles (NPs) with diameters of 16.1, 20.5, and 20.8 nm prepared from iron oleate precursors were coated with poly(maleic acid-alt-1-octadecene) (PMAcOD). The coating procedure exploited hydrophobic interactions of octadecene and oleic acid tails while hydrolysis of maleic anhydride moieties allowed the NP hydrophilicity. The PMAcOD nanostructure in water and the PMAcOD-coated NPs were studied using transmission electron microscopy, ζ-potential measurements, small-angle X-ray scattering, and fluorescence measurements. The combination of several techniques suggests that independently of the iron oxide core and oleic acid shell structures, PMAcOD encapsulates NPs, forming stable hydrophilic shells which withstand absorption of hydrophobic molecules, such as pyrene, without shell disintegration. Moreover, the PMAcOD molecules are predominantly attached to a single NP instead of self-assembling into the PMAcOD disklike nanostructures or attachment to several NPs. This leads to highly monodisperse aqueous samples with only a small fraction of NPs forming large aggregates due to cross-linking by the copolymer macromolecules.

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

“…We found that a small nanoparticle with a poly(maleic anhydride-alt-1-octadecene)-coat [25,30] seemed to accumulate selectively in liver sinusoidal endothelium ( Supplementary Fig. S1A).…”

“…59 Fe-labelled [22] and unlabelled [23] superparamagnetic iron-oxide nanocrystals or CdSe/CdS/ZnS-core-shellshell quantum dots [24] were encapsulated into an amphiphilic polymer (poly(maleic anhydride-alt-1-octadecene)as described [25]. Coupling of nanoparticles (6 µmol/l) to peptides with 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (6 mmol/l) was conducted as described [26].…”

Characterization of membrane materials and membrane coatings for bioreactor units of bioartificial kidneys

“…Poly(maleic anhydride-alt-1-octadecene) (PA-18) is an amphiphilic copolymer [32]. Coating of a hydrophobic surface with this copolymer in an aqueous environment could lead to an ordered arrangement of the amphiphilic molecules, resulting in the exposure of their hydrophilic portions, thus rendering the surface more hydrophilic.…”

Superparamagnetic iron oxide nanoparticles for MR imaging of pancreatic cancer: Potential for early diagnosis through targeted strategies

“…40 This method has yielded exceptionally stable and biocompatible NPs, but the high cost of PEGylated phospholipids limits their potential applications and has stimulated research for more affordable amphiphilic molecules. 41 …”