Hydrophilic Molybdenum Oxide Nanomaterials with Controlled Morphology and Strong Plasmonic Absorption for Photothermal Ablation of Cancer Cells

Abstract

The molybdenum oxide nanosheets have shown strong localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region. However, the long alky chains of ligands made them hydrophobic and less biocompatible. To meet the requirements of molybdenum based nanomaterials for use as a future photothermal therapy, a simple hydrothermal route has been developed for hydrophilic molybdenum oxide nanospheres and nanoribbons using a molybdenum precursor and poly(ethylene glycol) (PEG). First, molybdenum oxide nanomaterials prepared in the presence of PEG exhibit strong localized surface plasmon resonance (LSPR) absorption in near-infrared (NIR) region, compared with that of no PEG. Second, elevation of synthetic temperature leads to a gradual transformation of molybdenum oxide nanospheres into nanoribbons, entailing the evolution of an intense LSPR absorption in the NIR region. Third, as-prepared molybdenum oxide nanomaterials coated with PEG possess a hydrophilic property and thus can be directly used for biological applications without additional post treatments. Moreover, molybdenum oxide nanoribbons as a model of photothermal materials can efficiently convert the 980 nm wavelength laser energy into heat energy, and this localized hyperthermia produces the effective thermal ablation of cancer cells, meaning a potential photothermal material.

Oxygen‐Defected Molybdenum Oxides Hierarchical Nanostructure Constructed by Atomic‐Level Thickness Nanosheets as an Efficient Absorber for Solar Steam Generation

“…Thus, it's significant to explore TMOs as absorbers to expand the scope of materials used in solar evaporation system. Oxygen‐defected Molybdenum oxides (MoO x ), a low‐cost and environmental‐friendly material with tunable localized surface plasmon resonance (LSPR), has been applied in the field of photocatalysis and photothermal ablation (PTA) therapy . To the best of our knowledge, there has been only one investigation about MoO x for solar steam generation yet, however, the light‐to‐heat conversion efficiency is slightly low because of the non‐strong light absorption of MoO x within the whole solar spectrum range.…”

Magnolol Inhibits the Growth of Non-Small Cell Lung Cancer via Inhibiting Microtubule Polymerization

“…Lung cancer is the most common malignant tumor and the leading cause of cancer-related death in the world [5, 6]. More than 1.5 million new cases of lung cancer are diagnosed every year, approximately 80% of which are non-small cell lung cancer (NSCLC) [7-9].…”

CO2‐Assisted Fabrication of Two‐Dimensional Amorphous Molybdenum Oxide Nanosheets for Enhanced Plasmon Resonances

“…It leads to dramatic confinements of optical and electric fields in the vicinity of surface of metallic materials,w hich is capable of producing various surface effects,such as light-harvesting and enhanced Raman signals. [2] SPR has potential in various promising applications, such as photothermaltherapy, [3] biosensing, [4] photocatalysis, [5] and single-molecule spectroscopy. [6] Plasmonic frequencies are markedly affected by sizes,s hapes,a nd the surrounding mediums of nanostructured materials as well.…”