Hydrophilic Macromolecular Ferricenium Salts — Part I: Preparative and Spectroscopic Features of Selected Mononuclear Ferricenium Compound

Neuse, Eberhard W.

doi:10.1007/978-1-4615-9415-4_6

Cited by 8 publications

(1 citation statement)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sodium hydroxide protects the iron atom against oxidation, because the desired monocarboxylic acid was formed whereas if the reaction between ferrocene and a silver salt is carried out in neutral conditions, ferri-cenium salts are the products [27] (see above). Sodium hydroxide protects the iron atom against oxidation, because the desired monocarboxylic acid was formed whereas if the reaction between ferrocene and a silver salt is carried out in neutral conditions, ferri-cenium salts are the products [27] (see above).…”

Section: Resultsmentioning

confidence: 99%

New Synthesis of Ferrocene Monocarboxylic Acid and Systematic Studies on the Preparation of Related Key-Intermediates

Neto

Miller

Andrade

et al. 2002

Z. anorg. allg. Chem.

View full text Add to dashboard Cite

An improved technique for the preparation of ferrocenecarboxaldehyde and two new methods for the synthesis of ferrocenemonocarboxylic acid from the aldehyde or from acetyl ferrocene are described. Using the aldehyde or the monocarboxylic acid as starting materials, some important ferrocene key intermediates were prepared: mono-chlorocarbonyl ferrocene, alkali metal and ammonium ferrocenoates, ferrocene carboxyaldehyde diethylacetal, ferrocenecarboxamide, et . . ., as well as a new ferrocene derivative: piperazinium diferrocenoate.

show abstract

Section: Resultsmentioning

confidence: 99%

New Synthesis of Ferrocene Monocarboxylic Acid and Systematic Studies on the Preparation of Related Key-Intermediates

Neto

Miller

Andrade

et al. 2002

Z. anorg. allg. Chem.

View full text Add to dashboard Cite

show abstract

Antineoplastic activity of polyaspartamide-ferrocene conjugates

Caldwell

Meirim

Neuse

et al. 1998

Appl. Organometal. Chem.

Self Cite

View full text Add to dashboard Cite

The ferrocene/ferricenium redox system plays a significant role in biological oxidation, reduction and free‐radical reactions. Of particular interest are the findings of earlier investigations which showed certain water‐soluble ferricenium salts to possess appreciable antiproliferative activity against various murine tumor lines and a xenografted human colorectal adenocarcinoma. Solubility in water, a prerequisite for efficacious transport and dissipation in central circulation, was then proposed as a principal requirement for the ferrocene complex system to exert antineoplastic activity irrespective of the oxidation state in which it is administered. In order to shed more light on this question, we decided to investigate the antiproliferative properties of polymer–ferrocene conjugates containing the metal complex in the non‐oxidized (ferrocene) form while fulfilling the critical requirement of water solubility. To this end, five selected, water‐soluble conjugates, synthesized by reversible coupling of 4‐ferrocenylbutanoic acid to variously structured polyaspartamides featuring pendant primary amino groups as coupling sites, were tested in vitro against cultured HeLa cells at concentrations up to 50 µg Fe ml−1. Optimal antiproliferative activities, with IC50 in the range of 2–7 µg Fe ml−1, were determined for three compounds possessing tertiary‐amine functions susceptible to protonation at physiological pH. Lower activities (IC50 = 45–60 µg Fe ml−1) were demonstrated for two poly(ethylene oxide)‐containing conjugates. However, no reasonable structure–performance relationships can be derived at this stage from the small number of compounds tested. Copyright © 1998 John Wiley & Sons, Ltd.

show abstract

Molybdenum‐Containing polysalts of the poly[ferricene‐1,2(1,3:1,1′)diyl‐methylene] cation

Neuse

Khan

1987

Applied Organom Chemis

View full text Add to dashboard Cite

Poly Cferricene-1,2( 1,3:1 ,l')diyl-methylene) polycations, generated from the neutral precursor polymer 1 (M,, = 2800) by dioxygen (0,) oxidation in sulfuric acid medium, are paired first, in a model reaction, with the hexafluorophosphate anion and, in the principal series of experiments, with the two molybdenum-containing complex anions, octamolybdate and phosphododecamolybdate. The model poly(hexafluorophosphate) 2b, as well as the polymolybdates 2c and 2d, precipitate from aqueous acidic solution of the corresponding polysulfate 2a after anion exchange; scopically. In addition to the hexafluorophosphate anion, the model polysalts 2b contain small proportions, typically 5-15%, of sulfate anion (probably present as HSO;), indicating incompleteness of the anion exchange process. Analytical data suggest similarly incomplete exchange of anions also for the polymolybdates 2c and 2d. Oxidation of ferrocene units along the polymer chain is practically complete in the great majority of polysalts 2 synthesized. The molybdenum-containing polymers are of interest as plant micronutrients possessing slow-release properties.

show abstract

Hydrophilic Macromolecular Ferricenium Salts — Part I: Preparative and Spectroscopic Features of Selected Mononuclear Ferricenium Compound

Cited by 8 publications

References 59 publications

New Synthesis of Ferrocene Monocarboxylic Acid and Systematic Studies on the Preparation of Related Key-Intermediates

New Synthesis of Ferrocene Monocarboxylic Acid and Systematic Studies on the Preparation of Related Key-Intermediates

Antineoplastic activity of polyaspartamide-ferrocene conjugates

Molybdenum‐Containing polysalts of the poly[ferricene‐1,2(1,3:1,1′)diyl‐methylene] cation

Contact Info

Product

Resources

About