Hydrophilic interpenetrating polymer networks of poly(dimethyl siloxane) (PDMS) as biomaterial for cochlear implants

Abstract

Poly(dimethyl siloxane) (PDMS) was bulk-modified to develop a new intra-cochlear electrode that can closely hug the inner wall of scala tympani (ST). The hydrophilicity of bulk and surface of PDMS was changed using a sequential method for preparation of interpenetrating polymer networks (IPNs). A series of IPNs, based on PDMS and poly(acrylic acid) (PAAc), was synthesized and characterized by means of attenuated total reflectance Fourier transform infrared spectroscopy, water contact-angle measurement, dynamic mechanical thermal analysis and peel strength tests. The performances of actual-sized fabricated electrodes were assessed inside a transparent model of ST, which was filled with saline. The cell behavior of L929 fibroblasts on materials was studied in vitro.

First step toward near-infrared continuous glucose monitoring: in vivo evaluation of antibody coupled biomaterials

“…PDMS and PMMA were selected because of their known optical transparency in the NIR range. 8,9 Moreover, both materials are known to be biocompatible and are widely applied in medicine: PMMA as bone cement, contact and intra-ocular lenses, fixation and anchoring of artificial joints, and cranial reconstruction. PDMS is applied as breast implant, in facial reconstructive surgery, as orbital implant, in hearing aids, implantable rods for the delivery of contraceptives, and intraocular lenses.…”

“…Poly(methyl-methacrylate) (PMMA) and poly(dimethylsiloxane) (PDMS) are packaging materials fulfilling some of these criteria. They are NIR-transparent 8,9 and have shown to possess the required biocompatibility: PMMA as a bone cement and PDMS as part of breast implants. [10][11][12] However, upon implantation, fibrous encapsulation of an implant is often observed.…”

Cure kinetics and modeling the reaction of silicone rubber

“…Silicone rubbers generally, based on polydimethylsiloxane (PDMS), have special properties such as low toxicity, physiological inertness, good blood compatibility, and good thermal, oxidative, and mechanical stabilities, as well as flexibility and reliability over a wide range of temperatures and humidity [1][2][3][4]. These unique properties have allowed silicones to be used in various applications, from aerospace applications to medical devices, such as seals for the automotive industry; artificial skin, blood pumps, drug delivery systems, and implants for medical purposes; packaging and baking pans for the food industry; and connectors and cables for appliances and telecommunications [4][5][6][7][8][9][10].…”

“…Silicone rubber is a thermoset elastomer and it is solidified exothermally by a cross-linking reaction called curing [1][2][3][4][5][6][7][8][9][10][11]. To form a cured silicone rubber, peroxide and platinum catalysis are generally used.…”

Relationships between the morphology, swelling and mechanical properties of poly(dimethyl siloxane)/poly(acrylic acid) interpenetrating networks

“…Due to of the high water uptake of PAAc, the biocompatibility of its IPNs with silicone polymers has been studied. The best cell adhesion was observed for PAAc concentrations of approximately 20 wt% (Abbasi et al, 2006). The ultimate goal was to develop a new electrode (a so called segmented electrode) for cochlear implants.…”