Hydrophilic Cyanine Dyes as Contrast Agents for Near-infrared Tumor Imaging: Synthesis, Photophysical Properties and Spectroscopic In vivo Characterization ¶

Evaluation of Temperature-Sensitive, Indocyanine Green-Encapsulating Micelles for Noninvasive Near-Infrared Tumor Imaging

“…The amphiphilic character of ICG induces aggregation in aqueous solution resulting in adverse effects on its optical properties, such as lower quantum yields due to self quenching (17,18). Also, tumor localization is limited to a rather short period of time after administration due to the strong plasma protein binding of ICG and subsequent rapid clearance by the liver (19). Furthermore, ICG undergoes degradation in aqueous media, resulting in a loss of absorption and fluorescence due to saturation of the double bonds in the conjugated chain (20).…”

Optical Imaging of CCK2/Gastrin Receptor-Positive Tumors With a Minigastrin Near-Infrared Probe

“…In relation to interactions derived from the chromophore, plasma-binding properties of cyanines, in general, and their hydrophilic substitutes have already been observed. 25 The influence of other methodological effects on the aforementioned relationships should be rather minimal. For example, both tumor models have been implanted subcutaneously and had comparable sizes (approximately, 0.5 cm in diameter), so that light penetration depth was rather comparable between each other (depth variation was estimated to be lower than 0.3 mm).…”

Docosahexaenoic acid conjugated near infrared flourescence probe for in vivo early tumor diagnosis

“…This home built imaging system was reported in our previous work [12,13]. Briefly, the NIR system is composed of an excitation laser (λ=765.9 nm, NL-FC-2.0-763 laser light), a high sensitivity NIR CCD camera (PIXIS 512B, Princeton Instrumentation) and a 800 nm long pass filter for capturing the fluorescence from the tissue.…”