Hydrophilic Cu₃BiS₃ Nanoparticles for Computed Tomography Imaging and Photothermal Therapy

Abstract

Hydrophilic Cu3BiS3 nanoparticles (NPs) have been prepared using the thermal decomposition of precursor complexes in oily‐mixed solvent followed by coating the produced Cu3BiS3 NPs with polyvinylpyrrolidone (PVP). The resulting Cu3BiS3/PVP NPs remain stable in aqueous solutions over a long period of time, and meanwhile, they show low in vitro cytotoxicity and negligible toxicity to mice in vivo. Cu3BiS3/PVP NPs could operate as an efficient dual‐modal contrast agent to simultaneously enhance X‐ray computed tomography imaging and photothermal imaging of tumor model in vivo. Moreover, highly efficient ablation of cancer cells both in vitro and in vivo has been successfully achieved by combining Cu3BiS3/PVP NPs with near‐infrared (NIR) laser irradiation. All of the positive results in this study highlight that Cu3BiS3/PVP NPs could serve as a promising platform for cancer diagnosis and therapy.

Bismuth‐Based Nanomaterials: Recent Advances in Tumor Targeting and Synergistic Cancer Therapy Techniques

“…For the C6 and HeLa tumor model, the accumulating efficiencies of PEG‐gadolinium‐chelate functionalized Bi [ 21,22 ] and PEG‐Bi nanocrystals [ 23 ] reached 8 and 8.9%ID g −1 at 1 and 24 h p.i., respectively. Cu 3 BiS 3 NPs [ 24 ] and Bi subcarbonate nanotubes/Bi subcarbonate nanoclusters (BNTs/BNCs) [ 25 ] with a polyvinylpyrrolidone (PVP) coating showed a negligible EPR effect with a value of 0.75 and 4.0%ID g −1 in HeLa and Huh‐7 tumors, respectively, but a Bi 2 Se 3 spherical‐sponge [ 26 ] with the same coating showed a higher uptake by HeLa tumor, as high as 9.66%ID g −1 after 12 h p.i. and 15.0%ID g −1 Bi nanodrugs (NDs) [ 27 ] in U14 tumors after 24 h p.i .…”

CsxWO3 Nanorods Coated with Polyelectrolyte Multilayers as a Multifunctional Nanomaterial for Bimodal Imaging‐Guided Photothermal/Photodynamic Cancer Treatment

“…The strong X-ray attenuation ability and strong NIR absorbance of the polyelectrolyte-multilayer-coated Cs x WO 3 NRs (Cs x WO 3 NR@PEM) are used for enhanced CT and PAT imaging, respectively. The reason lies in the fact that CT imaging has advantages in 3D whole-body image and deep tissue penetration, [2] while PAT is characteristic of high spatial resolution, noninvasiveness, deep penetration, and accurate quantification along with the capability in guiding bulk tumor resection intraperatively. Based on CT/PAT bimodal imaging guidance, highly effective in vivo photodynamic (PD) and PT therapy of tumors is achieved after intratumoral injection with low dose of Cs x WO 3 NR@PEM upon 880 nm (biological window I) or 1064 nm (biological window II) laser irradiation.…”

“…Inspired by the remarkable physicochemical properties of tungsten bronze, such as high atomic number (Z = 73) and strong absorbance in the NIR region, in this study, we therefore develop a novel multifunctional theranostic system based on tungsten bronze, Cs x WO 3 nanorods (NRs). The reason lies in the fact that CT imaging has advantages in 3D whole-body image and deep tissue penetration, [2] while PAT is characteristic of high spatial resolution, noninvasiveness, deep penetration, and accurate quantification along with the capability in guiding bulk tumor resection intraperatively. The strong X-ray attenuation ability and strong NIR absorbance of the polyelectrolyte-multilayer-coated Cs x WO 3 NRs (Cs x WO 3 NR@PEM) are used for enhanced CT and PAT imaging, respectively.…”

“…The surface of negatively charged Cs x WO 3 NRs is coated with positively charged polyelectrolyte multilayers via the layer-by-layer (LBL) assembly technique, which greatly improves the biocompatibility of these NRs and their uptake by the cells. The reason lies in the fact that CT imaging has advantages in 3D whole-body image and deep tissue penetration, [2] while PAT is characteristic of high spatial resolution, noninvasiveness, deep penetration, and accurate quantification along with the capability in guiding bulk tumor resection intraperatively. Meanwhile, the Cs x WO 3 NR@PEM has wide and strong optical absorption in the whole NIR range of 780-2500 nm, covering both biological windows I and II.…”

Preparation of Naturally Active Melanin Nano‐Platforms Chelated with Barium Ions as a Potential X‐Ray‐Computed Tomography Contrast Agent

“…Over the last decade, nanoparticulate systems, mainly organic and inorganic nanoparticles, have gained attention as an X‐ray contrast agent, owing to their potential in cell tracking and targeted imaging applications ,. Nanoparticles (NPs) containing high atomic number elements strongly absorb X‐ray which result in a significant imaging contrast . However, application of these inorganic NPs are limited due to poor degradability and toxicity …”