Hydrophilic and Antibacterial Modification of Poly(lactic acid) Films by γ-ray Irradiation

Qi, Yanan; Ma, Hongchao; Du, Zhonghe; Yang, Bo; Wu, Jian; Wang, Rui; Zhang, Xiuqin

doi:10.1021/acsomega.9b03132

Cited by 44 publications

(23 citation statements)

References 44 publications

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“…Interestingly, PLA thin film without the presence of any PLA nanofiber demonstrated the highest cell proliferative activities among all the substrates used herein. The trend as mentioned above was likely caused by the lower hydrophobicity of pure PLA film, in comparison with PLA nanofiber coated substrate, leading to the optimized adsorption of serum protein for promoting cell adhesion and functions [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Fabrication of polylactic acid/paclitaxel nano fibers by electrospinning for cancer therapeutics

Chan

Li³

et al. 2020

BMC Chemistry

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Polylactic acid (PLA) is a thermoplastic and biodegradable polyester, largely derived from renewable resources such as corn starch, cassava starch and sugarcane. However, PLA is only soluble in a narrow range of solvents such as tetrahydrofuran, dioxane, chlorinated solvents and heated benzene. The limited choices of solvent for PLA dissolution have imposed significant challenges in the development of specifically engineered PLA nanofibers with electrospinning techniques. Generally, the electrospun polymeric materials have been rendered with unique properties such as high porosity and complex geometry while maintaining its biodegradability and biocompatibility for emerging biomedical applications. In this study, a new anticancer drug delivery system composed of PLA nanofibers with encapsulated paclitaxel was developed by the electrospinning of the respective nanofibers on top of a spin-coated thin film with the same chemical compositions. Our unique approach is meant for promoting strong bonding between PLA-based nanofibers and their respective films in order to improve the prolonged release properties and composite film stability within a fluctuative physiochemical environment during cell culture. PLA/paclitaxel nanofiber supported on respective polymeric films were probed by scanning electronic microscope, Fourier transform infrared spectrometer and water contact measurement for determining their surface morphologies, fibers’ diameters, molecular vibrational modes, and wettability, respectively. Moreover, PLA/paclitaxel nanofibers supported on respective spin-coated films at different loadings of paclitaxel were evaluated for their abilities in killing human colorectal carcinoma cells (HCT-116). More importantly, MTT assays showed that regardless of the concentrations of paclitaxel, the growth of HCT-116 was effectively inhibited by the prolonged release of paclitaxel from PLA/paclitaxel nanofibers. An effective prolonged delivery system of paclitaxel based on PLA nanofiber-based film has demonstrated exciting potentials for emerging applications as implantable drug delivery patch in post-surgical cancer eradication.

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Section: Discussionmentioning

confidence: 99%

Fabrication of polylactic acid/paclitaxel nano fibers by electrospinning for cancer therapeutics

Chan

Li³

et al. 2020

BMC Chemistry

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“…In order to make it suitable for special applications, PLA is modified by the addition of fillers or preparation of blends [8,19,22,26]. These include starch -to decrease the breakdown time of the polymer and reduce the manufacturing costs, and cellulose fibers -to enhance thermal resistance and rigidity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Abiotic Degradation on the Colorimetric Analysis, Mechanical Properties and Morphology of PLA Composites with Linen Fibers

Tor-Świątek¹,

Garbacz²

2021

Adv. Sci. Technol. Res. J.

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The manufacturing of composites from biomaterials enables the production of environment-and user-friendly biodegradable products. The matrix of such composite materials is made of biopolymers such as PLA or PGA, while the reinforcement is usually made of natural fibers. Such composites have unique physical and mechanical properties as well as distinctive, eye-catching performance and aesthetic characteristics such as texture, color or roughness. This paper presents the results of colorimetric examination of polymer-linen biocomposite materials under abiotic degradation. The colorimetric examination was made based on a CIELAB model determining the values of lightness, color saturation, chromatic colors and total color difference. The SEM morphology of the specimen surface fracture was also examined. The obtained results show a significant effect of abiotic degradation on the tested parameters.

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“…Interestingly, PLA thin lm without the presence of any PLA nano ber demonstrated the highest cell proliferative activities among all the substrates used herein. The trend as mentioned above was likely caused by the lower hydrophobicity of pure PLA lm, in comparison with PLA nano ber coated substrate, leading to the optimized adsorption of serum protein for promoting cell adhesion and functions [43].…”

Section: Discussionmentioning

confidence: 87%

Fabrication of Polylactic Acid/Paclitaxel Nano Fibers by Electrospinning for Cancer Therapeutics

Chan

et al. 2020

Preprint

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Background: Polylactic acid (PLA) is a thermoplastic and biodegradable polyester, largely derived from renewable resources such as corn starch, cassava starch and sugarcane. However, PLA is only soluble in a narrow range of solvents such as tetrahydrofuran, dioxane, chlorinated solvents and heated benzene. The limited choices of solvent for PLA dissolution have imposed singificant challenges in the development of specifically engineered PLA nanofibers with electrospinning techniques.Methods: Generally, the electrospun polymeric materials have been rendered with unique properties such as high porosity and complex geometry while maintaining its biodegradability and biocompatibility for emerging biomedical applications. In this study, a new drug delivery system composed of PLA nanofibers with encapsulated paclitaxel was developed by the electrospinning of the respective nanofibers on top of a spin-coated thin film with the same chemical compositions. Our unique approach is meant for promoting strong bonding between PLA-based nanofibers and their respective films in order to improve the prolonged release properties and composite film stability within a fluctuative phyiochemical environment during cell culture.Results: PLA/paclitaxel nanofiber supported on respective polymeric films were probed by scanning electronic microscope, Fourier transform infrared spectrometer and water contact measurement for determining their surface morphologies, fibers’ diameters, molecular vibrational modes, and wettability, respectively. Moreover, PLA/paclitaxel nanofibers supported on respective spin-coated films at different loadings of paclitaxel were evaluated for their abilities in killing human colorectal carcinoma cells (HCT-116). More importantly, MTT assays showed that regardless of the concentrations of paclitaxel, the growth of HCT-116 was effectively inhibited by the prolonged release of paclitaxel from PLA/paclitaxel nanofibers.Conclusions: An effective prolonged delivery system based on PLA nanofiber has demonstrated exciting potentials for emerging applications in cancer therapeutics.

show abstract

Hydrophilic and Antibacterial Modification of Poly(lactic acid) Films by γ-ray Irradiation

Cited by 44 publications

References 44 publications

Fabrication of polylactic acid/paclitaxel nano fibers by electrospinning for cancer therapeutics

Fabrication of polylactic acid/paclitaxel nano fibers by electrospinning for cancer therapeutics

Effect of Abiotic Degradation on the Colorimetric Analysis, Mechanical Properties and Morphology of PLA Composites with Linen Fibers

Fabrication of Polylactic Acid/Paclitaxel Nano Fibers by Electrospinning for Cancer Therapeutics

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