Hydronephrosis of Pregnancy: a Naturally Occurring Disorder in Non-human Primates Closely Resembling that in Man

Roberts, James A.; Wolf, Robert H.

doi:10.1159/000155373

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Maternal Changes With Pregnancy1

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2012

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Cited by 19 publications

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“…Travis and Holmes (1974) reported a linear increase in water consumption from the day of conception through GD 138, with a correlative significant increase in mean daily urine output. Evaluation of four species of nonhuman primates (M. mulatta, M. speciosa, E. patas, and P. troglodytes) showed that significant upper ureteral dilatation occurs during pregnancy, similar to findings in humans (Roberts and Wolf, 1971). (Chambers and Hearn, 1985).…”

Section: Maternal Changes With Pregnancysupporting

confidence: 64%

Reproduction and Breeding of Nonhuman Primates

Tardif¹,

Carville

Elmore

et al. 2012

Nonhuman Primates in Biomedical Research

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Section: Maternal Changes With Pregnancysupporting

confidence: 64%

Reproduction and Breeding of Nonhuman Primates

Tardif¹,

Carville

Elmore

et al. 2012

Nonhuman Primates in Biomedical Research

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Dollars and sense: Considerations for experimental model design

Ghoniem

Vandenberg

1994

Neurourology and Urodynamics

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Our recent review indicates that numerous factors are involved in selecting an animal model for the study of human disease processes. These include: anatomic, neurologic, physiologic, and pathologic parameters, concept of discrimination, volume of knowledge available, and costs. Regarding costs, data was collected from twelve medical research institutions in relation to the eight animals selected for comparative cost analysis: rhesus monkey, cynomolgus monkey, Sprague-Dawley (S.D.) rat, dog (mongrel), cat (mixed breed), swine (piglet), guinea pig, and rabbit. Biologically, the choices are vast and depend upon the investigator and the experimental design. Economically, pricing is a substantial constraint that varies widely and is institutionally dependent. Furthermore, within the same institution, costs differ according to the source of funding (e.g., private, federal, state, or institutional). However, if the investigator carefully considers these biologic and economic factors, it is possible to select an appropriate animal model.

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