1997
DOI: 10.1016/s0740-5472(97)00117-7
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Hydromorphone polymer implant A potential alternative to methadone maintenance

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Cited by 11 publications
(6 citation statements)
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“…For severe pain, slow release systems for potent opioids have been described. Subcutaneous hydromorphine implants have been used both in pain control and treatment of addiction, and systems releasing drugs for up to 8 weeks have been developed (32, 33). Liposomal slow release forms of opioids such as morphine have also been obtained (34).…”
Section: Discussionmentioning
confidence: 99%
“…For severe pain, slow release systems for potent opioids have been described. Subcutaneous hydromorphine implants have been used both in pain control and treatment of addiction, and systems releasing drugs for up to 8 weeks have been developed (32, 33). Liposomal slow release forms of opioids such as morphine have also been obtained (34).…”
Section: Discussionmentioning
confidence: 99%
“…Although most cancer pain can be readily managed with oral analgesic therapy, cancer pain has often been inaccurately assessed, undertreated, and inadequately managed (Chan & Woodruff, 1997;Rhodes & Grossman, 1997). For systematic and adequate cancer pain management, the World Health Organization (WHO) has created a Cancer Pain Relief Program and developed guidelines for the treatment of cancer pain, the American Pain Society (APS) suggested Quality Assurance Standards on Acute Pain and Cancer Pain, and the Agency for Health Care Policy and Research (AHCPR) pain panel also developed and suggested guidelines for cancer pain management (AHCPR, 1994;APS, 1995;WHO, 1996).…”
mentioning
confidence: 99%
“…For example, the MOP-R agonist methadone, which is used to treat heroin addiction, has been reported to be widely abused Simonsen et al, 2011a;Simonsen et al, 2011b;Tormoehlen et al, 2011). Although the use of "substitution" therapy with opioid agonists has been effective for some patients, it has remained controversial (Gerra et al, 2009;Ling et al, 1994;Rhodes & Grossman, 1997). However, as naltrexone induces aversive side-effects in humans and conditioned place aversion in rats (Mitchell et al, 2009), it does not appear to be rewarding itself.…”
Section: Abuse Potentialmentioning
confidence: 99%