Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA

Tebcharani, Laura; Akter, Nahida; Fan, Daiming; Lieleg, Oliver; Gibbs, Julianne M.; Boekhoven, Job

doi:10.1039/d3cc00888f

Chem. Commun.

2023

DOI: 10.1039/d3cc00888f

|View full text |Cite

Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA

Laura Tebcharani

Nahida Akter

Daiming Fan

et al.

Abstract: Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides. Moreover, we...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 22 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Linkage Pathways of DNA–Nanoparticle Conjugates and Biological Applications

Huang

Zhu

2023

Chemosensors

View full text Add to dashboard Cite

DNA–nanoparticle conjugates have extraordinary optical and catalytic properties that have attracted great interest in biosensing and biomedical applications. Combining these special qualities has made it possible to create extremely sensitive and selective biomolecule detection methods, as well as effective nanopharmaceutical carriers and therapy medications. In particular, inorganic nanoparticles, such as metal nanoparticles, metal–organic framework nanoparticles, or upconversion nanoparticles with relatively inert surfaces can easily bind to DNA through covalent bonds, ligand bonds, electrostatic adsorption, biotin–streptavidin interactions and click chemistry to form DNA–nanoparticle conjugates for a broad range of applications in biosensing and biomedicine due to their exceptional surface modifiability. In this review, we summarize the recent advances in the assembly mechanism of DNA–nanoparticle conjugates and their biological applications. The challenges of designing DNA–nanoparticle conjugates and their further applications are also discussed.

show abstract

Linkage Pathways of DNA–Nanoparticle Conjugates and Biological Applications

Huang

Zhu

2023

Chemosensors

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA

Abstract: Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides. Moreover, we...

Cited by 1 publication

References 22 publications

Linkage Pathways of DNA–Nanoparticle Conjugates and Biological Applications

Linkage Pathways of DNA–Nanoparticle Conjugates and Biological Applications

Contact Info

Product

Resources

About