Hydrolytically degradable POSS-PEG hybrid hydrogels prepared in aqueous phase with tunable mechanical properties, swelling ratio and degradation rate

Shen, Jinrui; Li, Heling; Lu, Cuifen; Yang, Guichun; Wang, Feiyi; Nie, Junqi; Hu, Xingjian; Dong, Nianguo; Shi, Jing

doi:10.1016/j.reactfunctpolym.2017.12.008

Cited by 26 publications

(19 citation statements)

References 33 publications

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“…Mono-mercapto POSS was grafted onto the maleimide-terminated tetra-arm PEG first and the macromolecules were then crosslinked with thiol ditelechelic polymers, which were alternated to offer different functions as required. For example, PEG bearing an ester bond (Figure ) and peptide were adopted to prepare hydrolytically degradable and enzyme-degradable hydrogels, respectively, and the degradation rate could be controlled by the feed ratio of POSS. , …”

Section: Construction Of Poss-containing Hydrogelsmentioning

confidence: 99%

Section: Construction Of Poss-containing Hydrogelsmentioning

confidence: 99%

“…For example, PEG bearing an ester bond (Figure 9) and peptide were adopted to prepare hydrolytically degradable and enzymedegradable hydrogels, respectively, and the degradation rate could be controlled by the feed ratio of POSS. 77,78 With careful design of the reaction conditions, some dualfunctional POSS molecules having one vertex substituted by a functional group and seven vertexes substituted by another functional group can be synthesized. Although their structures share similarity with monofunctional POSS molecules, they are of unique significance, considering the new opportunities for crosslinking, based on POSS brought by the second functionality.…”

Section: Monofunctional Poss As An End-capmentioning

confidence: 99%

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Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications

Shi

Yang

You

et al. 2020

ACS Materials Lett.

105

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Polyhedral oligomeric silsesquioxanes (POSS) represent the new frontier in hybrid materials science and engineering, because of their well-defined nanostructure and unique dual nature combining material properties from both inorganic siloxane cage and organic groups at the periphery. Recent advances in synthetic chemistry, combined with the controlled radical polymerization techniques, have significantly influenced the construction of POSS soft gel as emerging biomaterials and beyond. In this Review, the most recent developments in the design strategies of POSS-based hybrid soft gels are presented, with respect to different functions of architectural POSS, including POSS as a crosslinker, end-cap polymer chain, pendent group, etc. In addition, the insights into the uniqueness of POSS in microstructure and their different organic substituents in the enhancement of the hydrogel performance are illustrated. These sophisticated materials with multiple functions, oriented toward advanced therapeutic applications, are further summarized into several active domains in controlled drug delivery, 3D cell culture, tissue engineering, and wound healing. The recent new applications of using POSS hybrid soft gel in environmental health are also summarized in this Review. Finally, perspectives and challenges related to the further advancement of POSS-based hybrid soft gel materials are discussed.

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Section: Construction Of Poss-containing Hydrogelsmentioning

confidence: 99%

Section: Construction Of Poss-containing Hydrogelsmentioning

confidence: 99%

Section: Monofunctional Poss As An End-capmentioning

confidence: 99%

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Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications

Shi

Yang

You

et al. 2020

ACS Materials Lett.

105

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“…[12,13] Poly (ethylene glycol) (PEG) is a polyether with important applications ranging from industrial production to medicine due to its superior hydrophilicity, high biocompatibility, and so forth. [14] Particle size is a parameter that significantly affects the properties of the nanomaterial. Many methods have been investigated for Np synthesis.…”

Section: Introductionmentioning

confidence: 99%

Thermal and morphological investigation of the effect of POSS‐(PEG₂₀₀₀)₈ addition to UV curable PEGMEA/PEGDA formulation and simultaneously in situ formed silver nanoparticles

Kazancioglu

Batibay

Uner

et al. 2021

Journal of Polymer Science

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In this study, hybrid nanocomposites were synthesized by photo‐crosslinking of poly (ethylene glycol) methyl ether acrylate/poly (ethylene glycol) diacrylate monomer system using 2‐ (carboxymethoxy) thioxanthone and POSS‐(PEG2000)8. Additionally, AgNO3 was added to this formulation and in situ formation of silver nanoparticles onto hybrid nanocomposites were achieved in one‐step. UV–Vis spectroscopy technique was used as a very useful tool for surface plasmon resonance band detection of silver nanoparticles. In addition to thermogravimetric analyses which were performed in nitrogen atmosphere to determine the thermal stability of the nanocomposites, dynamic light scattering, and scanning electron microscopy techniques were also used for size and morphology of silver nanoparticles in a hybrid network. TGA analyses proved that even the addition of a very low amount of POSS‐(PEG2000)8 made noteworthy contribution to thermal stability especially in the presence of silver nanoparticles in the hybrid network. The swelling capacities of the prepared films were examined at 1, 3 and 24 h in phosphate buffer solution (pH = 7.4). It was found that film containing only POSS‐(PEG2000)8 had the highest swelling ratio in the shortest time.

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“…Additionally, various reports have been published on organic–inorganic nanocomposites, liquid crystalline materials and hydrogels using functional POSS nanoparticles . Besides, various POSS‐containing organic–inorganic hybrid materials have been achieved by chemical crosslinking reactions or physical blending …”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of POSS hybrid organogels using Menschutkin quaternization chemistry

Kilic

Balta

Saloglu

et al. 2018

Polymer International

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The present research describes a series of organic–inorganic hybrid gels based on polystyrene and polyhedral oligomeric silsesquioxanes (POSSs) prepared using free radical copolymerization and Menschutkin chemistry techniques. In the first step, poly(styrene‐co‐chloromethylstyrene) is readily achieved by thermally initiated radical copolymerization and the subsequently obtained copolymer reacts with diethanolamine functional POSS nanoparticles which are employed as the crosslinker. The resulting hybrid network possesses ionic moieties and inorganic POSS nanoparticles. The POSS‐containing hybrid gels exhibit excellent organic solvent absorption and show good mechanical behaviour. Gel containing 0.8 × 10−3 mmol of POSS(DEA)8 (DEA, diethanolamine) reached the highest swelling ratio; hence, the corresponding gel can absorb organic solvent up to 20× its weight. The rate constant, coefficients and diffusional behaviour of hybrid organogels in organic solvent were examined as well. The organic solvent intake of the hybrid gel follows a non‐Fickian type diffusion. © 2018 Society of Chemical Industry

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Hydrolytically degradable POSS-PEG hybrid hydrogels prepared in aqueous phase with tunable mechanical properties, swelling ratio and degradation rate

Cited by 26 publications

References 33 publications

Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications

Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications

Thermal and morphological investigation of the effect of POSS‐(PEG₂₀₀₀)₈ addition to UV curable PEGMEA/PEGDA formulation and simultaneously in situ formed silver nanoparticles

Synthesis and characterization of POSS hybrid organogels using Menschutkin quaternization chemistry

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Hydrolytically degradable POSS-PEG hybrid hydrogels prepared in aqueous phase with tunable mechanical properties, swelling ratio and degradation rate

Cited by 26 publications

References 33 publications

Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications

Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications

Thermal and morphological investigation of the effect of POSS‐(PEG2000)8 addition to UV curable PEGMEA/PEGDA formulation and simultaneously in situ formed silver nanoparticles

Synthesis and characterization of POSS hybrid organogels using Menschutkin quaternization chemistry

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Thermal and morphological investigation of the effect of POSS‐(PEG₂₀₀₀)₈ addition to UV curable PEGMEA/PEGDA formulation and simultaneously in situ formed silver nanoparticles