Hydrolytic instability and low-loading levels of temozolomide to magnetic PLGA nanoparticles remain challenging against glioblastoma therapy

Senturk, Fatih; Çakmak, Soner; Gümüşderelı́oğlu, Menemşe; Öztürk, Güler

doi:10.1016/j.jddst.2022.103101

Cited by 9 publications

(5 citation statements)

References 58 publications

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“…A detailed physicochemical characterization of iron oxide nanoparticles (XRD and ATR-FTIR) and PEGylated-PLGA polymers (1H NMR and ATR-FTIR) were also reported in our previous publications (8)(9)(10)29). In this study, IONs were fabricated by the thermal decomposition of iron-oleate precursor in the presence of an organic solvent with a high boiling point.…”

Section: Fabrication and Characterization Of Ions And Pegylated-plga ...mentioning

confidence: 80%

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

Senturk

2023

Hittite Journal of Science and Engineering

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Magnetic nano hyperthermia (MNH) is a promising technique for the treatment of a variety of malignancies. This non-invasive technique employs magnetic nanoparticles and alternating magnetic fields to generate local heat at the tumor location, which activates cell death pathways. However, the efficacy of MNH is dependent on the physicochemical properties of the magnetic nanoparticles, such as size, size distribution, magnetic properties, biocompatibility, and dispersibility in the medium. In this study, it is aimed to evaluate the heating capacity of poly (lactic-co-glycolic acid)-poly (ethylene glycol) di-block copolymer (PLGA-b-PEG) coated monodisperse iron oxide nanoparticles (IONs) as an effective mediator for MNH application. For this purpose, monodisperse IONs with a narrow size distribution and a mean particle size of 8.6 nm have been synthesized via the thermal decomposition method. The resulting IONs were then coated with the PEGylated-PLGA polymer and homogeneously dispersed in the polymeric matrix, which had a clearly defined spherical shape. Additionally, the specific absorption rate (SAR), reflecting the amount of heat dissipation from the NPs to the surrounding medium, was calculated for different concentrations (10, 5, 2.5, and 1.25 mg/mL) of PEGylated-PLGA-IONs. At 5 mg/mL PEGylated-PLGA-IONs (125 μgFe/mL) were found to have a maximum SAR value of 313 W/g. In conclusion, the homogenous dispersion of IONs in PEGylated-PLGA matrix may be one of the critical parameters to enhance the SAR value for MNH-based cancer therapy.

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Section: Fabrication and Characterization Of Ions And Pegylated-plga ...mentioning

confidence: 80%

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

Senturk

2023

Hittite Journal of Science and Engineering

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“…TMZ is stable in acidic pH and is hydrolyzed in physiological pH (higher than 7) and finally turns into MTIC. Then, MTIC is also hydrolyzed and converted into methyl diazonium ions which can cause purine and pyrimidine bases to be methylated and ultimately cause DNA damage and induce apoptosis [ 44 , 45 ]. Because TMZ can disrupt DNA replication by alkylating the O6 site of guanine (O6MeG), more than 50 % of patients with GBM do not respond to this drug due to the mechanism of methylguanine methyltransferase (MGMT) [ 46 , 47 ].…”

Section: Temozolomide In Chemotherapy: From History To Molecular Mech...mentioning

confidence: 99%

The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways

Mafi,

Hedayati,

Kahkesh

et al. 2024

Non-coding RNA Research

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“…Furthermore, other nanomaterials such as superparamagnetic nanoparticles [67][68][69][70][71] have been used to design TMZ-loading nanosystems to add new functionalities [51]. The use of superparamagnetic nanoparticles offers various advantages, including the possibility of i) actively targeting them under an external magnetic field, ii) gaining visibility in magnetic resonance imaging (MRI) by reducing both T1 and T2/T2* relaxation times, and iii) magnetic hyperthermia (discussed in the Section "TMZ with photodynamic therapy, photothermal therapy, and magnetic hyperthermia).…”

Section: Combinations Of Nanomaterialsmentioning

confidence: 99%

Current advances in temozolomide encapsulation for the enhancement of glioblastoma treatment

Iturrioz-Rodríguez¹,

Samprón²,

Matheu³

2023

Theranostics

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Glioblastoma is the most common and lethal brain tumor in adults. The incorporation of temozolomide (TMZ) into the standard treatment has increased the overall survival rate of glioblastoma patients. Since then, significant advances have been made in understanding the benefits and limitations of TMZ. Among the latter, the unspecific toxicity of TMZ, poor solubility, and hydrolyzation are intrinsic characteristics, whereas the presence of the blood-brain barrier and some tumor properties, such as molecular and cellular heterogeneity and therapy resistance, have limited the therapeutic effects of TMZ in treating glioblastoma. Several reports have revealed that different strategies for TMZ encapsulation in nanocarriers overcome those limitations and have shown that they increase TMZ stability, half-life, biodistribution, and efficacy, offering the promise for future nanomedicine therapies in handling glioblastoma. In this review, we analyze the different nanomaterials used for the encapsulation of TMZ to improve its stability, blood half-life and efficacy, paying special attention to polymer- and lipid-based nanosystems. To improve TMZ drug resistance, present in up to 50% of patients, we detail TMZ combined therapeutic with i) other chemotherapies, ii) inhibitors, iii) nucleic acids, iv) photosensitizers and other nanomaterials for photodynamic therapy, photothermal therapy, and magnetic hyperthermia, v) immunotherapy, and vi) other less explored molecules. Moreover, we describe targeting strategies, such as passive targeting, active targeting to BBB endothelial cells, glioma cells, and glioma cancer stem cells, and local delivery, where TMZ has demonstrated an improved outcome. To finish our study, we include possible future research directions that could help decrease the time needed to move from bench to bedside.

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Hydrolytic instability and low-loading levels of temozolomide to magnetic PLGA nanoparticles remain challenging against glioblastoma therapy

Cited by 9 publications

References 58 publications

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways

Current advances in temozolomide encapsulation for the enhancement of glioblastoma treatment

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