Hydrolytic degradation of POSS–PEG–lactide hybrid hydrogels

Wang, David; Fredericks, Peter M.; Haddad, Athir; Hill, David J. T.; Rasoul, Firas; Whittaker, Andrew K.

doi:10.1016/j.polymdegradstab.2010.10.005

Cited by 27 publications

(30 citation statements)

References 33 publications

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“…The chemical structure of POSS‐SH, PEG(20), and POSS–PEG(20) hydrogels was identified by FTIR spectra ( Figure ). The FTIR characteristic peaks of POSS‐SH indicate that there is a sharp and strong peak at 1107 cm −1 which belong to SiOSi stretching . It could be clearly seen that after Michael‐type addition the peak at 2560 cm −1 which was attributed to SH from POSS‐SH disappeared, revealing that the reaction was completely carried out.…”

Section: Resultsmentioning

confidence: 95%

“…The images reveal relatively porous networks, particularly for the POSS–PEG(20), which exhibited a highly homogenous macroporous spongelike structure and the average mesh size was about 30–100 µm. The porous nature of the hydrogels is usually ascribed to phase separation in the intermediate stages of polymerization . The images clearly demonstrate an increase in pore size of hydrogel with increasing molecular weight of PEG.…”

Section: Resultsmentioning

confidence: 97%

“…At the intermediate stage of polymerization, the phase separation occurs because of the incompatible of growing polymeric network with the remaining macromers and the water phase, resulting in an increase in the porosity of polymer network . Wang et al believe that hydrophobic POSS groups play a key role in increase the degree of porosity. From the TEM images we can see that the prepolymers with lower POSS loading level became progressively more soluble, in other words, a higher POSS loading level leads to the polymer network being less compatible with the water phase.…”

Section: Resultsmentioning

confidence: 99%

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Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Liu

Shen

et al. 2017

Macro Materials & Eng

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Biodegradable hydrogels have attracted much attention in tissue engineering due to their good biocompatibility and elastomeric behavior. In this work, a series of inorganic–organic polyhedral oligomeric silsequioxanes–poly(ethylene glycol) (POSS–PEG) hybrid hydrogels are prepared by covalently grafting POSS into PEG and further cross‐linked by matrix metalloproteinase (MMP) degradable peptide via Michael‐type addition polymerization. All the POSS–PEG hybrid hydrogels have a porous structure and high hydrophilic ability, and the grafted hydrophobic POSS macromers result in a higher mechanical properties and lower equilibrium swelling ratio. Additionally, the hydrogels can be biodegraded by MMP‐2 solution and the POSS loading level can influence the degradation rate. It is worth mentioning that POSS‐containing hybrid hydrogels can be prepared in water and be used for 3D cell culture. In vitro cell viability study on human umbilical vein endothelial cells for 3D cell culture indicates POSS–PEG hydrogels have good compatibility. All of these results suggest that these POSS–PEG hybrid hydrogels exhibit the potential for tissue engineering scaffolds.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

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Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Liu

Shen

et al. 2017

Macro Materials & Eng

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“…The triblock copolymers were synthesized by ROP of (L-lactide) with prepared polymer (A) in the presence of DBU as catalyst [11]. Briefly, the polymer (A) (4.168 g, 0.001 mole) was added to (L-lactide) (PLLA) (1.44 g, 0.01 mole) was dissolved in 75 ml of EDC in three neck flask equipped with argon gas.…”

Section: Preparation Of Poly (L-lactide)-poly (Ethylene Glycol)-sebacmentioning

confidence: 99%

Preparation and Swelling Behavior of L-Lactide Interpenetrating Networks

Sweah¹,

Al-Lami²,

Haddad³

2016

OJOPM

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Novel triblock copolymers of poly (L-lactide)-poly (ethylene glycol)-sebacate-poly (ethylene glycol)-poly (L-lactide) were synthesized by Ring-Opening Polymerization of different ratios of L-lactide with other three pre-prepared poly (ethylene glycol)sebacate-poly (ethylene glycol) polymers, coded A, B and C which had different poly (ethyleneglycol) chain lengths. The copolymers were characterized by FTIR and 1 H NMR spectroscopy, which indicated that the reaction of ROP took place and led to producing nine triblock copolymers having new different lactide chain lengths (n = 10, 25 and 50), AL 10 , AL 25 , AL 50 ,BL 10 , BL 25 , BL 50 , CL 10 , CL 25 , and CL 50. Nine polymer networks were also prepared from copolymers with sodium alginate S 1-S 9 and finally mixed with a solution of hydroxyl ethyl cellulose to form SH 1-SH 9 .

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“…The stretching vibration absorption bands of -C＝O, -CH-and O-H groups are located at 1744, 2920 and 3457 cm 1 , respectively. With the process of degradation, the O-H stretching vibration peak increases relative to other peaks, implying the increasing number in hydroxyl group at the end of PPDO chains after degradation [29,30] . These hydroxyl groups are from alcohol and carboxylic groups.…”

Section: Degradation Mechanism Of Ppdomentioning

confidence: 99%

Hydrolytic degradation behaviors of poly(p-dioxanone) in ambient environments

You¹,

Ding²,

Zhao³

et al. 2014

Chin J Polym Sci

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The effects of temperature and relative humidity on the hydrolytic degradation of poly(p-dioxanone) (PPDO) were investigated. The hydrolytic degradation behaviors were monitored by tracing the changes of water absorption, mechanical and crystalline properties, molecular weight and its distribution, surface morphologies, as well as infrared absorption peaks and hydrogen chemical shifts during the degradation. It is found that the water absorption increases whilst the intrinsic viscosity, tensile strength and elongation at break decrease as the temperature or relative humidity increases. With degradation time growing, the molecular weight drops and its distribution broadens. The crystallinity of PPDO has a tendency to increase at first and then to decrease, while the crystalline structure is not significantly changed. At the same time, some cracks are observed on the surface and keep growing and deepening. All results show that temperature plays more significant roles than relative humidity during the degradation. The analyses of Fourier transform infrared spectroscopy and hydrogen nuclear magnetic resonance spectroscopy reveal that the degradation of PPDO is a predominant hydrolysis of ester linkages.

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Hydrolytic degradation of POSS–PEG–lactide hybrid hydrogels

Cited by 27 publications

References 33 publications

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Preparation and Swelling Behavior of L-Lactide Interpenetrating Networks

Hydrolytic degradation behaviors of poly(p-dioxanone) in ambient environments

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