Hydrolytic cleavage of double-strand DNA by the water-soluble dicobalt(III) complexes of 1,4,7-Triazacyclononane-N-acetate

DNA Cleavage by Structurally Characterized Dinuclear Copper(II) Complexes Based on Triazine

“…[59] In a related system derived from a dicopper(II) complex bridged by a hydroxy group and a phenolate oxygen atom, low catecholase-like activity was also observed. [14] In contrast to the lack of catalytic DNA cleavage by 1, the doubly bridged dihydroxido-dicobalt(III) complexes constructed from tacn-Nacetate were found to be 40 times more reactive (under pseudo-Michaelis-Menten conditions k cat = 9.9ϫ 10 -4 s -1 ) [60] than 2.…”

Effect of the central metal ion on the cleavage of DNA by [M(TPA)Cl]ClO4 complexes (M=CoII, CuII and ZnII, TPA=tris(2-pyridylmethyl)amine): An efficient artificial nuclease for DNA cleavage

“…In addition, cobalt(III) complexes have also been extensively investigated and reported to reveal high catalytic activity [34][35][36][37][38]. Zinc(II) and copper(II) complexes derived from a wide range of ligands of varied skeletal structures and geometrical environments were found to be useful models for phosphodiester substrates [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][25][26][27][28][29][30][31].…”

“…Zinc(II) and copper(II) complexes derived from a wide range of ligands of varied skeletal structures and geometrical environments were found to be useful models for phosphodiester substrates [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][25][26][27][28][29][30][31]. Although it has been reported that binuclear metal complexes are in general more efficient in hydrolyzing the phosphate ester and DNA cleavage reactions [7,10,13,[29][30][31]37] compared to the related mononuclear species, many mononuclear complexes still function as good catalysts [19,8,[20][21][22]31,36,38].…”

“…Moreover, the studies on the PNA-cyclen series using different metal ions indicated that compared to cobalt(II) and zinc(II) complexes, the copper(II) complex was a better catalyst in the DNA cleavage process [18]. Although some research groups reported different complexes that can efficiently accelerate the cleavage of DNA [8,21,22,31,37,38] still the catalytic efficiency of the currently available chemical nucleases cannot be put in the same breath as that of the natural enzymes. Therefore, the following study was undertaken in an attempt to utilize ''efficient catalysts'' for DNA cleavage by using simple mononuclear cobalt(II), copper(II) and zinc(II) complexes based on tris(2-pyridylmethyl)amine (TPA) and to evaluate their reactivity.…”

Synthesis, Crystal Structures and DNA-Cleaving Activities of [Cemp]₂[MCl₄] (Cemp=<i>N</i>-Carbethoxymethyl-1,10-phenanthrolinium, M=Cu^II, Zn^II, Co^II, Ni^II and Mn^II)

“…In addition, Co(III), Mn(II) and Ni(II) complexes have also been reported to show high catalytic activities. [16][17][18][19] However, most of the complexes to date are confined to mono-, di-and multi-nuclear metal complexes, and ionic metal complexes in which the binding parts are separated from the cleaving centers, are less explored. 20,21) In constructing of metal complexes, 1,10-phenanthroline is an attractive building motif because it is well known that metal-bound planar phenanthroline complexes act as strong binders for double-stranded DNA and facilitate the hydrogen atom abstraction from the sugar unit.…”