Hydrolysis and transglycosylation activities of glycosidases from small intestine brush-border membrane vesicles

Julio-González, Lesbia Cristina; Moreno, F. Javier; Jimeno, María Luisa; Doyagüez, Elisa G.; Olano, Agustı́n; Corzo, Nieves; Hernández‐Hernández, Oswaldo

doi:10.1016/j.foodres.2020.109940

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“…Moreover, we found a significant increase in NADH production with age in the presence of the glycosylfructose energy substrate turanose. Turanose is hydrolysed to glucose and fructose by α-glucosidase, indicating a link between turanose and fructose metabolism ( Julio-Gonzalez et al., 2021 ; Tewari and Goldberg, 1991 ; Zagalak and Curtius, 1975 ). Turanose metabolism increased in the control cohort with age ( p =0.0072 and r =0.6755) ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts

Gerou

Hall

Woof

et al. 2021

Neurobiology of Aging

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Highlights Aging affects the metabolic profile of fibroblasts derived from ALS cases Increased NADH metabolism with age is observed in the presence of a specific set of catabolic energy substrates in healthy individuals Reduced NADH metabolism with age is observed in the presence of glycogen in the ALS cohort Disease progression rates in ALS cases correlate with fibroblast NADH production in the presence of a number of energy substrates including inosine

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Section: Resultsmentioning

confidence: 99%