Hydrogenation of aniline to cyclohexylamine on NaOH-promoted or lanthana supported nickel

Mink, G.; Horváth, L.

doi:10.1007/bf02475316

Cited by 30 publications

(12 citation statements)

References 10 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar effects have been seen in aniline hydrogenation where cyclohexylamine has been found to cause catalyst deactivation [19][20][21][22]. The rational for this is that the basic lone pair on the nitrogen atom forms a strong bond to the active metal.…”

Section: Discussionmentioning

confidence: 55%

Stereoselective Synthesis of Alicylic Amines

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 55%

Stereoselective Synthesis of Alicylic Amines

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Li et al [15][16][17]. For example, NaCl led to a yield of 87.3% for CHA and 10.6% for DCHA, which is almost in the same level as the blank experiment ( Table 1, entry 1), indicating the inertness of NaCl in this hydrogenation reaction.…”

Section: Concise Reportmentioning

confidence: 65%

“…Since the free electron pair on the nitrogen atom of amines causes a strong adsorption on the metallic catalyst, CHA cannot desorb from the active sites easily and then suffers from condensation reactions. [13,17] As a result, the side product DCHA was inevitably formed during the hydrogenation of NB to CHA without addition of additives (11.6% of DCHA, Table 1, entry 1). In order to investigate the influences of additives on selectivity of CHA, various types of alkali metal salts were added into the reactor.…”

Section: Resultsmentioning

confidence: 99%

“…[15,16] Besides the alkali metal hydroxides and nitrites, using strong basic metal oxides as support could also result in a high selectivity to primary amines in the vapor phase hydrogenation of aniline. [17] As stated above, although previous work suggests that alkali metal hydroxides and nitrites are efficient additives for suppressing the formation of secondary amines, the reasons are still unclear. What's more, the phenomenon with two dissimilar species exhibiting the same effect is rather confusing.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Insight into the Role of Additives in Catalytic Synthesis of Cyclohexylamine from Nitrobenzene

Wang

Mao

et al. 2018

Chin. J. Chem.

View full text Add to dashboard Cite

Cyclohexylamine is a versatile intermediate in various chemical industries, which can be expediently synthesized via hydrogenation of aniline or nitrobenzene. However, such processes always suffer from side reactions. Many reports have found that specific additives can suppress the formation of side products, but the mechanism is still not clear. In this work, results suggest that it is the hydroxide ion of alkali metal hydroxides, rather than the cations, which plays a key role in suppressing the side reactions on supported Ru‐based catalysts. With the assistance of LiOH, the selectivity toward cyclohexylamine increased from 85.4% to 100%. Side products, such as dicyclohexylamine, cyclohexanol and N‐isopropyl cyclohexylamine, could no longer be detected. Theoretical calculations further disclosed that addition of alkali metal hydroxides inhibited the dissociation of enamine and decreased the adsorption energy of cyclohexylamine, which might be the reasons for a better selectivity. However, the addition of alkali metal hydroxides reduced the activity of nitrobenzene hydrogenation by unfolding the condensation reaction route. To recover or even further enhance the catalytic performance, a second metal component was introduced and the resultant RuNi/AC exhibited a significant improvement in activity compared with Ru/AC.

show abstract

“…Compared with the content in the experimental group, more metabolites found in the control group metabolites are mostly intermediate metabolites of various biochemical reactions, such as 2-hydroxy-2-glutaric acid is the pentose phosphate intermediate [ 8 ], chlorinated acid cyclohexylamine is cyclohexylamine-generated intermediate [ 9 ], and l-methylinosine is the center of the cancer carbon metabolites [ 7 , 10 – 12 ]. If these products are not eliminated in time, there will be some harm to the human body.…”

Section: Discussionmentioning

confidence: 99%

Study on the Metabonomics Mechanism of Mongolian Medical Andai Therapy on Healthy People

Bao²,

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Andai therapy is a traditional therapy combining body, mind, and language with Mongolian characteristics. In the form of singing and dancing, it is widely popular among people of all ages in Mongolian areas of Inner Mongolia. According to Mongolian medicine, Heyi is one of the three elements of human body, and it can maintain life activities, promote blood circulation, and improve the functions of the sensory and mental consciousness. Andai therapy stimulates the whole body nerves and Heyi through music and dance, improves Heyi and blood operation, strengthens physique, improves immunity, effectively promotes physical and mental health, and plays a role in preventing and treating diseases. Objective. In this study, gas chromatography-mass spectrometry (GC-MS) was used to explore the mechanism of Andai therapy, so as to provide a new research direction for taking targeted prevention and treatment measures for diseases. Methods. Using gas chromatography-mass spectrometry (GC-MS) on all its cases baseline plasma to the targeted metabonomics testing, the differential metabolites of the experimental group (receiving Andai therapy) and control group (without receiving Andai therapy), analysis-related metabolite function, and screening of metabolites and related pathways through adjusting mechanism to explore the related factors are compared, to study the mechanism of the influence of Mongolian medical Andai therapy on the metabolism of different healthy people. Results. The differences in metabolic numbers between the experimental group and the control group are 114, such as cyclohexylamine chlorinated acid, 2,4-2 aminobutyric acid bitter almond alcohol, l-methyl inosine, 2-picolinate, and 2-hydroxy-2-glutaric acid metabolite content of the control group that are significantly higher than the experimental group, experimental group’s other substance content is significantly higher than that of the control group, and two groups’ metabolite content was obviously different. The number of differential metabolites between the female experimental group and the female control group was 119, and the number of differential metabolites between the male experimental group and the male control group was 48.

show abstract

Hydrogenation of aniline to cyclohexylamine on NaOH-promoted or lanthana supported nickel

Abstract: In the vapor phase, the selectivity of the title reaction could be increased to about 90 % by promoting traditional type nickel catalysts with NaOH. The use of strongly basic lanthana as support resulted in 95-99 % selectivity.

Cited by 30 publications

References 10 publications

Stereoselective Synthesis of Alicylic Amines

Stereoselective Synthesis of Alicylic Amines

Insight into the Role of Additives in Catalytic Synthesis of Cyclohexylamine from Nitrobenzene

Study on the Metabonomics Mechanism of Mongolian Medical Andai Therapy on Healthy People

Contact Info

Product

Resources

About