Hydrogen sulfide supplement attenuates the apoptosis of retinal ganglion cells in experimental glaucoma

Curcumin protects trabecular meshwork cells against hydrogen peroxide-induced oxidative stress and apoptosis via Nrf2-keap1 pathway

“…The application of a new imaging technique called "detection of apoptosis retinal cells" (DARC) has shown that the level of RGC apoptosis is predictive of disease severity in patients with glaucomatous neurodegeneration [16]. Moreover, treatment with agents that inhibit RGC apoptosis attenuate glaucoma [17,18]. Apoptosis is initially characterized by a series of morphological changes, including cellular shrinkage, membrane blebbing, and nuclear chromatin condensation.…”

The effects of intravitreal H2S application on apoptosis in the retina and cornea in experimental glaucoma model

“…Recently, there have been questions whether any such effect of H 2 S could be applicable in glaucoma. Therefore it has been tested in some previous studies …”

“…Therefore it has been tested in some previous studies. [16][17][18][19][20] Apoptosis is essential in normal development for the maintenance of tissue homeostasis. 21,22 The process of apoptosis induction mechanism is initiated by several factors, including decrease in growth factors and DNA damage.…”

Extracellular Signal-Regulated Kinase 1/2 Pathway Is Insufficiently Involved in the Neuroprotective Effect by Hydrogen Sulfide Supplement in Experimental Glaucoma

“…In our previous work, we concluded that H 2 S supplement with exogenous donor significantly attenuated the apoptosis of RGC, thus effectively improving RGC survival in experimental glaucoma, and the neuroprotection by H 2 S probably correlated with the suppression of glial activation, inhibition of proinflammatory pathways, attenuation of oxidative stress, and downregulation of autophagy in retina. 28 However, the mechanisms underlying the phenomena still remained unclear. In this study, we additionally introduced an inhibitor of ERK 1/ 2 pathway, one of the most fundamental signaling pathways within mammalian cellular pathophysiological regulation, in combination with H 2 S supplement to treat COH rats.…”

“…Afterward, we kept on with this subject and illustrated the antiapoptosis effect of H 2 S on RGC as well as involvement of various pathological activities in experimental glaucoma. 28 These discoveries generally outline the role of H 2 S in glaucoma and have increasingly drawn attention to the therapeutic potential of H 2 S in glaucoma treatment.…”