Hydrogen Sulfide: Redox Metabolism and Signaling

Banerjee, Ruma

doi:10.1089/ars.2011.3912

Cited by 29 publications

(23 citation statements)

References 32 publications

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“…H 2 S has been recognized as a potent antioxidant, antiinflammatory, and physiological gaseous molecule (1,4,42,48). Recent evidence from human and animal studies has demonstrated that H 2 S is directly involved in various diseases, including hypertension, atherosclerosis, and end-stage renal disease (42).…”

Section: Msramentioning

confidence: 99%

“…Cysteine is a substrate of the two pyridoxal-5¢-phosphate-dependent enzymes, CBS and CSE, generating hydrogen sulfide (H 2 S) (42). H 2 S, which has been known for decades as a toxic gas, is currently recognized as a gaseous physiological molecule (1,11,42,48). Recent studies have demonstrated that H 2 S performs a cytoprotective role in a variety of organs, including the heart, brain, intestine, and kidney, against ischemia/reperfusion (I/ R) injury (5,41,49).…”

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confidence: 99%

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Protective Role of Methionine Sulfoxide Reductase A Against Ischemia/Reperfusion Injury in Mouse Kidney and Its Involvement in the Regulation of Trans-Sulfuration Pathway

Kim

Choi

Jung

et al. 2013

Antioxidants & Redox Signaling

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Aims: Methionine sulfoxide reductase A (MsrA) and methionine metabolism are associated with oxidative stress, a principal cause of ischemia/reperfusion (I/R) injury. Herein, we investigated the protective role of MsrA against kidney I/R injury and the involvement of MsrA in methionine metabolism and the transsulfuration pathway during I/R. Results: We found that MsrA gene-deleted mice (MsrA -/ -) were more susceptible to kidney I/R injury than wild-type mice (MsrA +/+ ). Deletion of MsrA enhanced renal functional and morphological impairments, congestion, inflammatory responses, and oxidative stress under I/R conditions. Concentrations of homocysteine and H 2 S in the plasma of control MsrA -/ -mice were significantly lower than those in control MsrA +/+ mice. I/R reduced the levels of homocysteine and H 2 S in both MsrA +/+ and MsrA -/ -mice, and these reductions were significantly more profound in MsrA -/ -than in MsrA +/+ mice. I/R reduced the expression and activities of cystathionine-b-synthase (CBS) and cystathionine-c-lyase (CSE), both of which are H 2 S-producing enzymes, in the kidneys. These reductions were more profound in the MsrA -/ -mice than in the MsrA +/+ mice. Innovation: The data provided herein constitute the first in vivo evidence for the involvement of MsrA in regulating methionine metabolism and the trans-sulfuration pathway under normal and I/R conditions. Conclusion: Our data demonstrate that MsrA protects the kidney against I/R injury, and that this protection is associated with reduced oxidative stress and inflammatory responses. The data indicate that MsrA regulates H 2 S production during I/R by modulating the expression and activity of the CBS and CSE enzymes.

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Section: Msramentioning

confidence: 99%

mentioning

confidence: 99%

Protective Role of Methionine Sulfoxide Reductase A Against Ischemia/Reperfusion Injury in Mouse Kidney and Its Involvement in the Regulation of Trans-Sulfuration Pathway

Kim

Choi

Jung

et al. 2013

Antioxidants & Redox Signaling

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“…obs.). H 2 S has been documented to play important roles in redox metabolism and cell signalling [26]; however a possible function in parasitic protozoa has not been characterized.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol

Williams

Yarlett

Aon

et al. 2014

Molecular and Biochemical Parasitology

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“…The vast majority of metabolites in humans are uncharacterized, and it is likely that many of these are of microbial origin. These compounds can have important epigenetic and regulatory effects on the host 24 , 25 and are also often important substrates for host cell metabolism [26] . SCFAs are particularly abundant microbial products in the gut.…”

Section: The Holistic Concept Of Isotope Probingmentioning

confidence: 99%

Stable-Isotope Probing of Human and Animal Microbiome Function

Berry

Loy

2018

Trends in Microbiology

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Humans and animals host diverse communities of microorganisms important to their physiology and health. Despite extensive sequencing-based characterization of host-associated microbiomes, there remains a dramatic lack of understanding of microbial functions. Stable-isotope probing (SIP) is a powerful strategy to elucidate the ecophysiology of microorganisms in complex host-associated microbiotas. Here, we suggest that SIP methodologies should be more frequently exploited as part of a holistic functional microbiomics approach. We provide examples of how SIP has been used to study host-associated microbes in vivo and ex vivo. We highlight recent developments in SIP technologies and discuss future directions that will facilitate deeper insights into the function of human and animal microbiomes.

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Hydrogen Sulfide: Redox Metabolism and Signaling

Cited by 29 publications

References 32 publications

Protective Role of Methionine Sulfoxide Reductase A Against Ischemia/Reperfusion Injury in Mouse Kidney and Its Involvement in the Regulation of Trans-Sulfuration Pathway

Protective Role of Methionine Sulfoxide Reductase A Against Ischemia/Reperfusion Injury in Mouse Kidney and Its Involvement in the Regulation of Trans-Sulfuration Pathway

Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol

Stable-Isotope Probing of Human and Animal Microbiome Function

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