2011
DOI: 10.1074/jbc.m111.298208
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Hydrogen Sulfide Protects the Retina from Light-induced Degeneration by the Modulation of Ca2+ Influx

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Cited by 135 publications
(161 citation statements)
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“…These oxidants cause the oxidative modification of proteins and lipids seen in vivo in patients with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. H 2 S also protects retinal neurons from light-induced degeneration by suppressing the excessive Ca 2 + influx (43). The cytoprotective effect was also found by David Lefer and colleagues in the cardiovascular system.…”
Section: Introductionmentioning
confidence: 56%
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“…These oxidants cause the oxidative modification of proteins and lipids seen in vivo in patients with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. H 2 S also protects retinal neurons from light-induced degeneration by suppressing the excessive Ca 2 + influx (43). The cytoprotective effect was also found by David Lefer and colleagues in the cardiovascular system.…”
Section: Introductionmentioning
confidence: 56%
“…CBS and CSE are localized to the cytoplasm, while 3MST is mainly localized to the mitochondrial matrix, with a pH of approximately 8 (45). 3MST is localized to neurons in the brain and retina (43,58). Neither CBS nor CSE was found in the retina.…”
Section: Mst With Catmentioning
confidence: 98%
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“…S-adenosylmethionine allosterically activates CBS (152) and although CBS contains a heme group that can be inhibited by CO, neither nitric oxide (NO) nor O 2 appears effective at physiological concentrations (4). CSE and both cytosolic and mitochondrial CAT activity are inhibited by calcium, independent of calmodulin (104,105).…”
Section: Metabolic Relationships Between H 2 S and Omentioning
confidence: 99%
“…Despite the fact that H 2 S is recognized to be neuroprotective [12,13] and serves as a protective mediator for various tissues [14][15][16], the similar function of bound sulfur is not well known. Therefore, further study is required to resolve the individual mechanisms by which H 2 S and bound sulfur may perform physiological roles.…”
Section: Introductionmentioning
confidence: 99%