Hydrogen sulfide protects against toxicant acrolein-induced ferroptotic cell death in Sertoli cells
Zhimin Mao,
Qun Ji,
Ping Chen
et al.
Abstract:Acrolein (ACR) is a ubiquitous environmental pollutant and byproduct of lipid peroxidation that has been implicated in male infertility. However, the molecular mechanisms underlying ACR-induced toxicity in Sertoli cells remain unclear. Given its role in inducing oxidative stress, we examined whether ferroptosis, an iron-dependent form of regulated cell death, could mediate ACR toxicity in Sertoli cells. We also tested if hydrogen sulfide (H2S), which has antioxidant and ACR detoxifying properties, could protec… Show more
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